Longitudinal Assessment of Lipid and Hepatic Clinical Parameters in Workers Involved With the Demolition of Perfluoroalkyl Manufacturing Facilities
Objective: To examine in a longitudinal occupational assessment whether changes in serum concentrations of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) are associated with changes in non-highdensity lipoprotein (HDL) cholesterol. Methods: Baseline and end-of-project PFOA, PFOS,...
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| Veröffentlicht in: | Journal of occupational and environmental medicine 2012-08, Vol.54 (8), p.974-983 |
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| container_title | Journal of occupational and environmental medicine |
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| creator | Olsen, Geary W. Ehresman, David J. Buehrer, Betsy D. Gibson, Barbara A. Butenhoff, John L. Zobel, Larry R. |
| description | Objective: To examine in a longitudinal occupational assessment whether changes in serum concentrations of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) are associated with changes in non-highdensity lipoprotein (HDL) cholesterol. Methods: Baseline and end-of-project PFOA, PFOS, lipid, and hepatic clinical chemistries were measured in 204 workers involved with the demolition of former perfluoroalkyl manufacturing facilities. Analyses were restricted to the 179 workers who did not take lipidlowering medications. Two thirds had baseline PFOA and PFOS levels similar to the general population. Results: The change in non-HDL cholesterol was not associated with the changes in PFOA or PFOS. An increase in HDL was associated with an increase in PFOA, although the magnitude was small. This increase in HDL resulted in a decrease in the total cholesterol/HDL ratio. Conclusion: Adverse associations were not observed between changes in PFOA, PFOS, non-HDL cholesterol, HDL, and hepatic clinical chemistries. |
| doi_str_mv | 10.1097/JOM.0b013e31825461d2 |
| format | Article |
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Methods: Baseline and end-of-project PFOA, PFOS, lipid, and hepatic clinical chemistries were measured in 204 workers involved with the demolition of former perfluoroalkyl manufacturing facilities. Analyses were restricted to the 179 workers who did not take lipidlowering medications. Two thirds had baseline PFOA and PFOS levels similar to the general population. Results: The change in non-HDL cholesterol was not associated with the changes in PFOA or PFOS. An increase in HDL was associated with an increase in PFOA, although the magnitude was small. This increase in HDL resulted in a decrease in the total cholesterol/HDL ratio. Conclusion: Adverse associations were not observed between changes in PFOA, PFOS, non-HDL cholesterol, HDL, and hepatic clinical chemistries.</description><identifier>ISSN: 1076-2752</identifier><identifier>EISSN: 1536-5948</identifier><identifier>DOI: 10.1097/JOM.0b013e31825461d2</identifier><identifier>PMID: 22842914</identifier><identifier>CODEN: JOEMFM</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Alkanesulfonic Acids - blood ; Biological and medical sciences ; Caprylates - blood ; Chemical and industrial products toxicology. Toxic occupational diseases ; Chemical Industry ; Cholesterol ; Cholesterol, LDL - blood ; Cholesterol, VLDL - blood ; Demolition ; Female ; Fluorocarbons - blood ; Humans ; Lipids ; Lipids - blood ; Lipoproteins ; Lipoproteins, HDL - blood ; Liver ; Liver - metabolism ; Longitudinal Studies ; Male ; Manufacturing ; Medical sciences ; Middle Aged ; Occupational Exposure ; Occupational health ; ORIGINAL ARTICLES ; Toxicology ; Various organic compounds ; Workers</subject><ispartof>Journal of occupational and environmental medicine, 2012-08, Vol.54 (8), p.974-983</ispartof><rights>Copyright © 2012 American College of Occupational and Environmental Medicine</rights><rights>2012The American College of Occupational and Environmental Medicine</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Aug 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4692-1b58eed7211d0011bb2ddbbb560975bba7abb1679e3751d3db5ec6f615de6bd3</citedby><cites>FETCH-LOGICAL-c4692-1b58eed7211d0011bb2ddbbb560975bba7abb1679e3751d3db5ec6f615de6bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/44997851$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/44997851$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26259627$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22842914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olsen, Geary W.</creatorcontrib><creatorcontrib>Ehresman, David J.</creatorcontrib><creatorcontrib>Buehrer, Betsy D.</creatorcontrib><creatorcontrib>Gibson, Barbara A.</creatorcontrib><creatorcontrib>Butenhoff, John L.</creatorcontrib><creatorcontrib>Zobel, Larry R.</creatorcontrib><title>Longitudinal Assessment of Lipid and Hepatic Clinical Parameters in Workers Involved With the Demolition of Perfluoroalkyl Manufacturing Facilities</title><title>Journal of occupational and environmental medicine</title><addtitle>J Occup Environ Med</addtitle><description>Objective: To examine in a longitudinal occupational assessment whether changes in serum concentrations of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) are associated with changes in non-highdensity lipoprotein (HDL) cholesterol. Methods: Baseline and end-of-project PFOA, PFOS, lipid, and hepatic clinical chemistries were measured in 204 workers involved with the demolition of former perfluoroalkyl manufacturing facilities. Analyses were restricted to the 179 workers who did not take lipidlowering medications. Two thirds had baseline PFOA and PFOS levels similar to the general population. Results: The change in non-HDL cholesterol was not associated with the changes in PFOA or PFOS. An increase in HDL was associated with an increase in PFOA, although the magnitude was small. This increase in HDL resulted in a decrease in the total cholesterol/HDL ratio. Conclusion: Adverse associations were not observed between changes in PFOA, PFOS, non-HDL cholesterol, HDL, and hepatic clinical chemistries.</description><subject>Adult</subject><subject>Alkanesulfonic Acids - blood</subject><subject>Biological and medical sciences</subject><subject>Caprylates - blood</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chemical Industry</subject><subject>Cholesterol</subject><subject>Cholesterol, LDL - blood</subject><subject>Cholesterol, VLDL - blood</subject><subject>Demolition</subject><subject>Female</subject><subject>Fluorocarbons - blood</subject><subject>Humans</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Lipoproteins</subject><subject>Lipoproteins, HDL - blood</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Manufacturing</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Occupational Exposure</subject><subject>Occupational health</subject><subject>ORIGINAL ARTICLES</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><subject>Workers</subject><issn>1076-2752</issn><issn>1536-5948</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAURSMEoqXwB4AsISQ2KbFjO_GyGigtmqpdVOoysuOXjmcce7CdVv0OfhiHGYrUDaz8Fudd2_cUxVtcHeNKNJ-_X14cV6rCNdS4JYxyrMmz4hCzmpdM0PZ5nquGl6Rh5KB4FeO6qjDDFXtZHBDSUiIwPSx-Lr27NWnSxkmLTmKEGEdwCfkBLc3WaCSdRmewlcn0aGGNM30Gr2SQIyQIERmHbnzYzOO5u_P2DjS6MWmF0grQFxi9Ncl4NwdeQRjs5IOXdvNg0YV00yD7NAXjbtGp7M2MQnxdvBikjfBmfx4V16dfrxdn5fLy2_niZFn2lAtSYsVaAN0QjHX-GlaKaK2UYjzXw5SSjVQK80ZA3TCsa60Y9HzgmGngStdHxadd7Db4HxPE1I0m9mCtdOCn2OGKCyyoaNr_QOsaM0q4yOiHJ-jaTyGX-5vihLKcmCm6o_rgYwwwdNtgRhkeMtTNerust3uqN6-934dPagT9uPTHZwY-7gEZs6chSNeb-JfjhAlO5vvbHXfv7WxxY6d7CN0KpE2rf73h3W51HZMPj9GUitwUw_UvaDjLxA</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>Olsen, Geary W.</creator><creator>Ehresman, David J.</creator><creator>Buehrer, Betsy D.</creator><creator>Gibson, Barbara A.</creator><creator>Butenhoff, John L.</creator><creator>Zobel, Larry R.</creator><general>Lippincott Williams & Wilkins</general><general>The American College of Occupational and Environmental Medicine</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>7U2</scope></search><sort><creationdate>201208</creationdate><title>Longitudinal Assessment of Lipid and Hepatic Clinical Parameters in Workers Involved With the Demolition of Perfluoroalkyl Manufacturing Facilities</title><author>Olsen, Geary W. ; Ehresman, David J. ; Buehrer, Betsy D. ; Gibson, Barbara A. ; Butenhoff, John L. ; Zobel, Larry R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4692-1b58eed7211d0011bb2ddbbb560975bba7abb1679e3751d3db5ec6f615de6bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Alkanesulfonic Acids - blood</topic><topic>Biological and medical sciences</topic><topic>Caprylates - blood</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Chemical Industry</topic><topic>Cholesterol</topic><topic>Cholesterol, LDL - blood</topic><topic>Cholesterol, VLDL - blood</topic><topic>Demolition</topic><topic>Female</topic><topic>Fluorocarbons - blood</topic><topic>Humans</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Lipoproteins</topic><topic>Lipoproteins, HDL - blood</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Manufacturing</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Occupational Exposure</topic><topic>Occupational health</topic><topic>ORIGINAL ARTICLES</topic><topic>Toxicology</topic><topic>Various organic compounds</topic><topic>Workers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olsen, Geary W.</creatorcontrib><creatorcontrib>Ehresman, David J.</creatorcontrib><creatorcontrib>Buehrer, Betsy D.</creatorcontrib><creatorcontrib>Gibson, Barbara A.</creatorcontrib><creatorcontrib>Butenhoff, John L.</creatorcontrib><creatorcontrib>Zobel, Larry R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Safety Science and Risk</collection><jtitle>Journal of occupational and environmental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olsen, Geary W.</au><au>Ehresman, David J.</au><au>Buehrer, Betsy D.</au><au>Gibson, Barbara A.</au><au>Butenhoff, John L.</au><au>Zobel, Larry R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal Assessment of Lipid and Hepatic Clinical Parameters in Workers Involved With the Demolition of Perfluoroalkyl Manufacturing Facilities</atitle><jtitle>Journal of occupational and environmental medicine</jtitle><addtitle>J Occup Environ Med</addtitle><date>2012-08</date><risdate>2012</risdate><volume>54</volume><issue>8</issue><spage>974</spage><epage>983</epage><pages>974-983</pages><issn>1076-2752</issn><eissn>1536-5948</eissn><coden>JOEMFM</coden><abstract>Objective: To examine in a longitudinal occupational assessment whether changes in serum concentrations of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) are associated with changes in non-highdensity lipoprotein (HDL) cholesterol. Methods: Baseline and end-of-project PFOA, PFOS, lipid, and hepatic clinical chemistries were measured in 204 workers involved with the demolition of former perfluoroalkyl manufacturing facilities. Analyses were restricted to the 179 workers who did not take lipidlowering medications. Two thirds had baseline PFOA and PFOS levels similar to the general population. Results: The change in non-HDL cholesterol was not associated with the changes in PFOA or PFOS. An increase in HDL was associated with an increase in PFOA, although the magnitude was small. This increase in HDL resulted in a decrease in the total cholesterol/HDL ratio. Conclusion: Adverse associations were not observed between changes in PFOA, PFOS, non-HDL cholesterol, HDL, and hepatic clinical chemistries.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>22842914</pmid><doi>10.1097/JOM.0b013e31825461d2</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of occupational and environmental medicine, 2012-08, Vol.54 (8), p.974-983 |
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| subjects | Adult Alkanesulfonic Acids - blood Biological and medical sciences Caprylates - blood Chemical and industrial products toxicology. Toxic occupational diseases Chemical Industry Cholesterol Cholesterol, LDL - blood Cholesterol, VLDL - blood Demolition Female Fluorocarbons - blood Humans Lipids Lipids - blood Lipoproteins Lipoproteins, HDL - blood Liver Liver - metabolism Longitudinal Studies Male Manufacturing Medical sciences Middle Aged Occupational Exposure Occupational health ORIGINAL ARTICLES Toxicology Various organic compounds Workers |
| title | Longitudinal Assessment of Lipid and Hepatic Clinical Parameters in Workers Involved With the Demolition of Perfluoroalkyl Manufacturing Facilities |
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