Effect of intranasal administration of Lactobacillus fermentum CJL-112 on horizontal transmission of influenza virus in chickens
ABSTRACT The aim of this study was to determine whether intranasal administration of Lactobacillus sp. could prevent horizontal transmission of H9N2 avian influenza virus (AIV) in specific-pathogen-free chickens. Three-week-old chickens received 500 μL of 1.5 × 109 cfu of Lactobacillus fermentum CJL...
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| Veröffentlicht in: | Poultry science 2012-10, Vol.91 (10), p.2517-2522 |
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| creator | Youn, H.-N. Lee, Y.-N. Lee, D.-H. Park, J.-K. Yuk, S.-S. Lee, H.-J. Yeo, J.-M. Yang, S.-Y. Lee, J.-B. Park, S.-Y. Choi, I.-S. Song, C.-S. |
| description | ABSTRACT
The aim of this study was to determine whether intranasal administration of Lactobacillus sp. could prevent horizontal transmission of H9N2 avian influenza virus (AIV) in specific-pathogen-free chickens. Three-week-old chickens received 500 μL of 1.5 × 109 cfu of Lactobacillus fermentum CJL-112 strain (CJL) intranasally for 7 d before and 14 d after a challenge. Challenged chickens, each inoculated with H9N2 AIV, were kept in either direct or indirect contact with naive chickens, and morbidity and viral shedding were monitored. We demonstrated that the intranasal administration of CJL significantly decreased the number of chickens with viral shedding from the gastrointestinal tract in the indirect contact chickens (P < 0.001) and also significantly reduced viral shedding from the respiratory tract in the challenged (P < 0.05) and the direct contact chickens (P < 0.001) than those in the control group. Hence, the use of this lactobacilli strain may constitute a novel and effectively plausible alternative to prevent and control H9N2 AIV infection in chickens. |
| doi_str_mv | 10.3382/ps.2012-02334 |
| format | Article |
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The aim of this study was to determine whether intranasal administration of Lactobacillus sp. could prevent horizontal transmission of H9N2 avian influenza virus (AIV) in specific-pathogen-free chickens. Three-week-old chickens received 500 μL of 1.5 × 109 cfu of Lactobacillus fermentum CJL-112 strain (CJL) intranasally for 7 d before and 14 d after a challenge. Challenged chickens, each inoculated with H9N2 AIV, were kept in either direct or indirect contact with naive chickens, and morbidity and viral shedding were monitored. We demonstrated that the intranasal administration of CJL significantly decreased the number of chickens with viral shedding from the gastrointestinal tract in the indirect contact chickens (P < 0.001) and also significantly reduced viral shedding from the respiratory tract in the challenged (P < 0.05) and the direct contact chickens (P < 0.001) than those in the control group. Hence, the use of this lactobacilli strain may constitute a novel and effectively plausible alternative to prevent and control H9N2 AIV infection in chickens.</description><identifier>ISSN: 0032-5791</identifier><identifier>EISSN: 1525-3171</identifier><identifier>DOI: 10.3382/ps.2012-02334</identifier><identifier>PMID: 22991537</identifier><language>eng</language><publisher>Oxford, UK: Oxford University Press</publisher><subject>Animals ; Chickens ; Influenza A Virus, H9N2 Subtype ; Influenza in Birds - microbiology ; Influenza in Birds - transmission ; Influenza in Birds - virology ; Lactobacillus fermentum - physiology ; Probiotics ; Specific Pathogen-Free Organisms</subject><ispartof>Poultry science, 2012-10, Vol.91 (10), p.2517-2522</ispartof><rights>2012 Poultry Science Association Inc. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-5c122ccb1209df41223511a2afa772937c925217351fa2e88466a9fcd1d113453</citedby><cites>FETCH-LOGICAL-c365t-5c122ccb1209df41223511a2afa772937c925217351fa2e88466a9fcd1d113453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22991537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Youn, H.-N.</creatorcontrib><creatorcontrib>Lee, Y.-N.</creatorcontrib><creatorcontrib>Lee, D.-H.</creatorcontrib><creatorcontrib>Park, J.-K.</creatorcontrib><creatorcontrib>Yuk, S.-S.</creatorcontrib><creatorcontrib>Lee, H.-J.</creatorcontrib><creatorcontrib>Yeo, J.-M.</creatorcontrib><creatorcontrib>Yang, S.-Y.</creatorcontrib><creatorcontrib>Lee, J.-B.</creatorcontrib><creatorcontrib>Park, S.-Y.</creatorcontrib><creatorcontrib>Choi, I.-S.</creatorcontrib><creatorcontrib>Song, C.-S.</creatorcontrib><title>Effect of intranasal administration of Lactobacillus fermentum CJL-112 on horizontal transmission of influenza virus in chickens</title><title>Poultry science</title><addtitle>Poult Sci</addtitle><description>ABSTRACT
The aim of this study was to determine whether intranasal administration of Lactobacillus sp. could prevent horizontal transmission of H9N2 avian influenza virus (AIV) in specific-pathogen-free chickens. Three-week-old chickens received 500 μL of 1.5 × 109 cfu of Lactobacillus fermentum CJL-112 strain (CJL) intranasally for 7 d before and 14 d after a challenge. Challenged chickens, each inoculated with H9N2 AIV, were kept in either direct or indirect contact with naive chickens, and morbidity and viral shedding were monitored. We demonstrated that the intranasal administration of CJL significantly decreased the number of chickens with viral shedding from the gastrointestinal tract in the indirect contact chickens (P < 0.001) and also significantly reduced viral shedding from the respiratory tract in the challenged (P < 0.05) and the direct contact chickens (P < 0.001) than those in the control group. Hence, the use of this lactobacilli strain may constitute a novel and effectively plausible alternative to prevent and control H9N2 AIV infection in chickens.</description><subject>Animals</subject><subject>Chickens</subject><subject>Influenza A Virus, H9N2 Subtype</subject><subject>Influenza in Birds - microbiology</subject><subject>Influenza in Birds - transmission</subject><subject>Influenza in Birds - virology</subject><subject>Lactobacillus fermentum - physiology</subject><subject>Probiotics</subject><subject>Specific Pathogen-Free Organisms</subject><issn>0032-5791</issn><issn>1525-3171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kb1PwzAQxS0EoqUwsqKMLCm-c5w0I6rKlyqxwBy5jq0aEjvYCRKd-NNxaYGJyXr27707PRNyDnTK2AyvujBFCphSZCw7IGPgyFMGBRySMaUMU16UMCInIbxQipDnxTEZIZYlcFaMyedCayX7xOnE2N4LK4JoElG3xpoQdW-c3T4uhezdSkjTNENItPKtsv3QJvOHZQqASaTWzpuNs330b4NCa0LYu43VzaDsRiTvxke_sYlcG_mqbDglR1o0QZ3tzwl5vlk8ze_S5ePt_fx6mUqW8z7lEhClXAHSstZZFIwDCBRaFAWWrJAlcoQi3mqBajbL8lyUWtZQA7CMswm53OV23r0NKvRV3E-qphFWuSFUQDNgmGOGEU13qPQuBK901XnTCv8RoWpbetWFalt69V165C_20cOqVfUv_dPy32w3dP9l7T6QfQEvgIoK</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Youn, H.-N.</creator><creator>Lee, Y.-N.</creator><creator>Lee, D.-H.</creator><creator>Park, J.-K.</creator><creator>Yuk, S.-S.</creator><creator>Lee, H.-J.</creator><creator>Yeo, J.-M.</creator><creator>Yang, S.-Y.</creator><creator>Lee, J.-B.</creator><creator>Park, S.-Y.</creator><creator>Choi, I.-S.</creator><creator>Song, C.-S.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121001</creationdate><title>Effect of intranasal administration of Lactobacillus fermentum CJL-112 on horizontal transmission of influenza virus in chickens</title><author>Youn, H.-N. ; Lee, Y.-N. ; Lee, D.-H. ; Park, J.-K. ; Yuk, S.-S. ; Lee, H.-J. ; Yeo, J.-M. ; Yang, S.-Y. ; Lee, J.-B. ; Park, S.-Y. ; Choi, I.-S. ; Song, C.-S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-5c122ccb1209df41223511a2afa772937c925217351fa2e88466a9fcd1d113453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Chickens</topic><topic>Influenza A Virus, H9N2 Subtype</topic><topic>Influenza in Birds - microbiology</topic><topic>Influenza in Birds - transmission</topic><topic>Influenza in Birds - virology</topic><topic>Lactobacillus fermentum - physiology</topic><topic>Probiotics</topic><topic>Specific Pathogen-Free Organisms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Youn, H.-N.</creatorcontrib><creatorcontrib>Lee, Y.-N.</creatorcontrib><creatorcontrib>Lee, D.-H.</creatorcontrib><creatorcontrib>Park, J.-K.</creatorcontrib><creatorcontrib>Yuk, S.-S.</creatorcontrib><creatorcontrib>Lee, H.-J.</creatorcontrib><creatorcontrib>Yeo, J.-M.</creatorcontrib><creatorcontrib>Yang, S.-Y.</creatorcontrib><creatorcontrib>Lee, J.-B.</creatorcontrib><creatorcontrib>Park, S.-Y.</creatorcontrib><creatorcontrib>Choi, I.-S.</creatorcontrib><creatorcontrib>Song, C.-S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Poultry science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Youn, H.-N.</au><au>Lee, Y.-N.</au><au>Lee, D.-H.</au><au>Park, J.-K.</au><au>Yuk, S.-S.</au><au>Lee, H.-J.</au><au>Yeo, J.-M.</au><au>Yang, S.-Y.</au><au>Lee, J.-B.</au><au>Park, S.-Y.</au><au>Choi, I.-S.</au><au>Song, C.-S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of intranasal administration of Lactobacillus fermentum CJL-112 on horizontal transmission of influenza virus in chickens</atitle><jtitle>Poultry science</jtitle><addtitle>Poult Sci</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>91</volume><issue>10</issue><spage>2517</spage><epage>2522</epage><pages>2517-2522</pages><issn>0032-5791</issn><eissn>1525-3171</eissn><abstract>ABSTRACT
The aim of this study was to determine whether intranasal administration of Lactobacillus sp. could prevent horizontal transmission of H9N2 avian influenza virus (AIV) in specific-pathogen-free chickens. Three-week-old chickens received 500 μL of 1.5 × 109 cfu of Lactobacillus fermentum CJL-112 strain (CJL) intranasally for 7 d before and 14 d after a challenge. Challenged chickens, each inoculated with H9N2 AIV, were kept in either direct or indirect contact with naive chickens, and morbidity and viral shedding were monitored. We demonstrated that the intranasal administration of CJL significantly decreased the number of chickens with viral shedding from the gastrointestinal tract in the indirect contact chickens (P < 0.001) and also significantly reduced viral shedding from the respiratory tract in the challenged (P < 0.05) and the direct contact chickens (P < 0.001) than those in the control group. Hence, the use of this lactobacilli strain may constitute a novel and effectively plausible alternative to prevent and control H9N2 AIV infection in chickens.</abstract><cop>Oxford, UK</cop><pub>Oxford University Press</pub><pmid>22991537</pmid><doi>10.3382/ps.2012-02334</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Chickens Influenza A Virus, H9N2 Subtype Influenza in Birds - microbiology Influenza in Birds - transmission Influenza in Birds - virology Lactobacillus fermentum - physiology Probiotics Specific Pathogen-Free Organisms |
| title | Effect of intranasal administration of Lactobacillus fermentum CJL-112 on horizontal transmission of influenza virus in chickens |
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