Development of an Intramolecular Aryne Ene Reaction and Application to the Formal Synthesis of (±)-Crinine

A general and high yielding annulation strategy for the synthesis of various carbo- and heterocycles, based on an intramolecular aryne ene reaction is described. It was found that the geometry of the olefin is crucial to the success of the reaction, with exclusive migration of the trans-allylic-H ta...

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Veröffentlicht in:	Journal of the American Chemical Society 2012-09, Vol.134 (37), p.15572-15580
Hauptverfasser:	Candito, David A, Dobrovolsky, Dennis, Lautens, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Amaryllidaceae Alkaloids - chemical synthesis Amaryllidaceae Alkaloids - chemistry Models, Molecular Stereoisomerism
Online-Zugang:	Volltext
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