Combining patient-level and summary-level data for Alzheimer’s disease modeling and simulation: a beta regression meta-analysis

Our objective was to develop a beta regression (BR) model to describe the longitudinal progression of the 11 item Alzheimer’s disease (AD) assessment scale cognitive subscale (ADAS-cog) in AD patients in both natural history and randomized clinical trial settings, utilizing both individual patient a...

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Veröffentlicht in:	Journal of pharmacokinetics and pharmacodynamics 2012-10, Vol.39 (5), p.479-498
Hauptverfasser:	Rogers, James A., Polhamus, Daniel, Gillespie, William R., Ito, Kaori, Romero, Klaus, Qiu, Ruolun, Stephenson, Diane, Gastonguay, Marc R., Corrigan, Brian
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - epidemiology Alzheimer Disease - pathology Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Databases, Factual - statistics & numerical data Disease Progression Humans Longitudinal Studies Original Paper Pharmacology/Toxicology Pharmacy Randomized Controlled Trials as Topic - methods Randomized Controlled Trials as Topic - standards Regression Analysis Statistics as Topic - methods Veterinary Medicine/Veterinary Science
Online-Zugang:	Volltext
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