Paracoccidioides brasiliensis induces secretion of IL-6 and IL-8 by lung epithelial cells. Modulation of host cytokine levels by fungal proteases

Paracoccidioides brasiliensis is a pathogenic, dimorphic fungus that causes paracoccidioidomycosis, a systemic human mycosis that is highly prevalent in Latin America. In this study, we demonstrated that P. brasiliensis yeasts induced interleukin (IL)-8 and IL-6 secretion by human lung epithelial A5...

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Veröffentlicht in:	Microbes and infection 2012-10, Vol.14 (12), p.1077-1085
Hauptverfasser:	Maza, Paloma K., Oliveira, Priscila, Toledo, Marcos S., Paula, Daisy M.B., Takahashi, Helio K., Straus, Anita H., Suzuki, Erika
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Line Cytokines Epithelial cells Epithelial Cells - immunology Epithelial Cells - microbiology Fundamental and applied biological sciences. Psychology Humans Interferon-gamma - metabolism Interleukin-6 - metabolism Interleukin-8 - metabolism MAPK-ERK kinases Microbiology Miscellaneous Mitogen-Activated Protein Kinases - metabolism Mycology p38 MAPK Paracoccidioides - immunology Paracoccidioides brasiliensis Peptide Hydrolases - metabolism Proteases Proteolysis Signal Transduction Tumor Necrosis Factor-alpha - metabolism
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