Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages

Reverse cholesterol transport (RCT), a process to deliver excess cholesterol from the periphery to the liver for excretion from body, is a major atheroprotective property of high-density lipoproteins. As major transporters for cholesterol efflux in macrophages, ATP-binding cassette transporter A1 (A...

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Veröffentlicht in:	The Journal of nutritional biochemistry 2012-10, Vol.23 (10), p.1271-1276
Hauptverfasser:	Ku, Chai Siah, Park, Youngki, Coleman, Sara L, Lee, Jiyoung
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters ABCA1 ABCG1 Acetophenones - pharmacology acetylation adenosine triphosphate agonists Animals ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter, Subfamily G, Member 1 ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Benzopyrans - pharmacology Biological and medical sciences Cell Line, Tumor cholesterol Cholesterol - metabolism eicosapentaenoic acid excretion Fatty acids Fatty Acids, Unsaturated - pharmacology Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gene Expression Regulation high density lipoprotein histone deacetylase histones Hydrocarbons, Fluorinated - pharmacology linoleic acid Lipoproteins - genetics Lipoproteins - metabolism liver Liver X Receptors macrophages Macrophages - drug effects Macrophages - metabolism messenger RNA Mice Orphan Nuclear Receptors - genetics Orphan Nuclear Receptors - metabolism PPAR gamma - genetics PPAR gamma - metabolism protein kinase C RAW 264.7 macrophage Real-Time Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Sulfonamides - pharmacology transcription (genetics) Transfection Vertebrates: anatomy and physiology, studies on body, several organs or systems
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