Molecular characteristics of extended-spectrum β-lactamase-producing Escherichia coli in Japan: emergence of CTX-M-15-producing E. coli ST131

Abstract We investigated the molecular characteristics of ESBL-producing Escherichia coli in Japan. A total of 101 clinical isolates of ESBL-positive E. coli collected in Japan between June 2008 and November 2009 were studied. Among the 101 strains, 97 were positive for CTX-M, while 47 and two were...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 2012-10, Vol.74 (2), p.201-203
Hauptverfasser:	Kuroda, Hitoshi, Yano, Hisakazu, Hirakata, Yoichi, Arai, Kazuaki, Endo, Shiro, Kanamori, Hajime, Yamamoto, Hiromi, Ichimura, Sadahiro, Ogawa, Miho, Shimojima, Masahiro, Komatsu, Mayumi, Jonai, Teruko, Itagaki, Sachiko, Nonomiya, Yuriko, Suwabe, Akira, Kaku, Mitsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Bacteriology beta-Lactamases - genetics beta-Lactamases - secretion Biological and medical sciences Child Child, Preschool Cluster Analysis CTX-M-15 DNA, Bacterial - chemistry DNA, Bacterial - genetics ESBLs Escherichia coli Escherichia coli - classification Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli - isolation & purification Escherichia coli Infections - epidemiology Escherichia coli Infections - microbiology Female Fundamental and applied biological sciences. Psychology Genotype Humans Infant Infectious Disease Infectious diseases Internal Medicine Japan - epidemiology Male Medical sciences Microbiology Middle Aged Miscellaneous Molecular Epidemiology Multilocus Sequence Typing Sequence Analysis, DNA Young Adult
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Zusammenfassung:	Abstract We investigated the molecular characteristics of ESBL-producing Escherichia coli in Japan. A total of 101 clinical isolates of ESBL-positive E. coli collected in Japan between June 2008 and November 2009 were studied. Among the 101 strains, 97 were positive for CTX-M, while 47 and two were positive for TEM and SHV, respectively. Sequencing revealed that CTX-M-14 was most common (49/101), followed by CTX-M-27 (22/101) and CTX-M-15 (8/101). Based on MLST data, seven of eight CTX-M-15 producers belonged to ST131. This is the first report about clinical isolates of E. coli ST131 possessing CTX-M-15 in Japan.
ISSN:	0732-8893 1879-0070
DOI:	10.1016/j.diagmicrobio.2012.06.011