Antagonism of Supraspinal Histamine H3 Receptors Modulates Spinal Neuronal Activity in Neuropathic Rats

There is growing evidence supporting a role for histamine H3 receptors in the modulation of pathological pain. To further our understanding of this modulation, we examined the effects of a selective H3 receptor antagonist, 6-((3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy)-N-methyl-3-pyri...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2012-10, Vol.343 (1), p.13-20
Hauptverfasser:	McGaraughty, Steve, Chu, Katharine L., Cowart, Marlon D., Brioni, Jorge D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzazepines - pharmacology Benzazepines - therapeutic use Histamine H3 Antagonists - pharmacology Histamine H3 Antagonists - therapeutic use Locus Coeruleus - drug effects Locus Coeruleus - physiology Male Neuralgia - drug therapy Neuralgia - metabolism Neuralgia - pathology Neurons - drug effects Neurons - metabolism Neurons - physiology Niacinamide - analogs & derivatives Niacinamide - pharmacology Niacinamide - therapeutic use Pyramidal Tracts - drug effects Pyramidal Tracts - physiology Rats Rats, Sprague-Dawley Receptors, Histamine H3 - metabolism Receptors, Histamine H3 - physiology Spinal Cord - drug effects Spinal Cord - metabolism Spinal Cord - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!