Risks of developing psychiatric disorders in pediatric patients with psoriasis
Background Symptoms of psoriasis can be embarrassing and distressing, and may increase risk of developing psychiatric disorders in young people. Objective We sought to compare incidences of psychiatric disorders between pediatric patients with psoriasis and psoriasis-free control subjects. Methods P...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 2012-10, Vol.67 (4), p.651-657.e2 |
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| container_title | Journal of the American Academy of Dermatology |
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| creator | Kimball, Alexa B., MD Wu, Eric Q., PhD Guérin, Annie, MSc Yu, Andrew P., PhD Tsaneva, Magda, BA Gupta, Shiraz R., PharmD Bao, Yanjun, PhD Mulani, Parvez M., PhD |
| description | Background Symptoms of psoriasis can be embarrassing and distressing, and may increase risk of developing psychiatric disorders in young people. Objective We sought to compare incidences of psychiatric disorders between pediatric patients with psoriasis and psoriasis-free control subjects. Methods Patients ( |
| doi_str_mv | 10.1016/j.jaad.2011.11.948 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1040996909</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0190962211022584</els_id><sourcerecordid>1040996909</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-e5b4e1216677f42364d62b77e9e4738028ea6efd3c10ca66400710a91178847d3</originalsourceid><addsrcrecordid>eNp9kU2LFDEQhoMo7rj6BzxIXwQvPVals0kHRFgWv2BR8OMcMkm1m9me7jbVszL_3jQzKngQChLC81aFp4R4irBGQP1yu956H9cSENelrGrviRWCNbU2rbkvVoAWaqulPBOPmLcAYFVjHoozKWW5aLUSHz8nvuVq7KpId9SPUxq-VxMfwk3yc06hionHHClzlYZqonh6nvycaJi5-pnmmxIYc_Kc-LF40Pme6cnpPBff3r75evW-vv707sPV5XUdlMK5pouNIpSotTGdko1WUcuNMWRJmaYF2ZLX1MUmIASvtQIwCN4imrZVJjbn4sWx75THH3vi2e0SB-p7P9C4Z4egwFptwRZUHtGQR-ZMnZty2vl8KJBbPLqtWzy6xaMrVTyW0LNT__1mR_FP5Le4Ajw_AZ6D77vsh5D4L6cVtkbpwr06clRs3CXKjkMRF4rITGF2cUz__8frf-KhT0MqE2_pQLwd93konh06lg7cl2Xjy8IRQcqLVjW_AHvspPo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1040996909</pqid></control><display><type>article</type><title>Risks of developing psychiatric disorders in pediatric patients with psoriasis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Kimball, Alexa B., MD ; Wu, Eric Q., PhD ; Guérin, Annie, MSc ; Yu, Andrew P., PhD ; Tsaneva, Magda, BA ; Gupta, Shiraz R., PharmD ; Bao, Yanjun, PhD ; Mulani, Parvez M., PhD</creator><creatorcontrib>Kimball, Alexa B., MD ; Wu, Eric Q., PhD ; Guérin, Annie, MSc ; Yu, Andrew P., PhD ; Tsaneva, Magda, BA ; Gupta, Shiraz R., PharmD ; Bao, Yanjun, PhD ; Mulani, Parvez M., PhD</creatorcontrib><description>Background Symptoms of psoriasis can be embarrassing and distressing, and may increase risk of developing psychiatric disorders in young people. Objective We sought to compare incidences of psychiatric disorders between pediatric patients with psoriasis and psoriasis-free control subjects. Methods Patients (<18 years) with continuous health plan enrollment 6 months before and after first psoriasis diagnosis (index date) were selected (Thomson Reuters MarketScan database, 2000-2006 [Thomson Reuters, New York, NY]). Patients with psoriasis (N = 7404) were matched 1:5 on age and sex to psoriasis-free control subjects (N = 37,020). Patients were followed from index date to first diagnosis of a psychiatric disorder (ie, alcohol/drug abuse, depression, anxiety disorder, bipolar disorder, suicidal ideation, eating disorder), end of data availability, or disenrollment. Patients with psychiatric diagnoses or psychotropic medication use before the index date were excluded. Cox proportional hazard models controlling for age, sex, and comorbidities were used to estimate the effect of psoriasis on risks of developing psychiatric disorders. Results Patients with psoriasis were significantly more at risk of developing psychiatric disorders versus control subjects (5.13% vs 4.07%; P = .0001; hazard ratio = 1.25; P = .0001), especially depression (3.01% vs 2.42%; P = .0036; hazard ratio = 1.25; P = .0053) and anxiety (1.81% vs 1.35%; P = .0048; hazard ratio = 1.32; P = .0045). Limitations Retrospective, observational studies of medical claims data are typically limited by overall quality and completeness of data and accuracy of coding for diagnoses and procedures. Conclusions Pediatric patients with psoriasis had an increased risk of developing psychiatric disorders, including depression and anxiety, compared with psoriasis-free control subjects.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/j.jaad.2011.11.948</identifier><identifier>PMID: 22243764</identifier><identifier>CODEN: JAADDB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; anxiety ; Anxiety Disorders - drug therapy ; Anxiety Disorders - epidemiology ; Anxiety Disorders - psychology ; Biological and medical sciences ; Bipolar Disorder - drug therapy ; Bipolar Disorder - epidemiology ; Bipolar Disorder - psychology ; Cohort Studies ; Comorbidity ; depression ; Depressive Disorder - drug therapy ; Depressive Disorder - epidemiology ; Depressive Disorder - psychology ; Dermatology ; Female ; General aspects ; Humans ; Incidence ; Male ; Medical sciences ; Mental Disorders - drug therapy ; Mental Disorders - epidemiology ; pediatrics ; Proportional Hazards Models ; psoriasis ; Psoriasis - epidemiology ; Psoriasis - psychology ; Psoriasis. Parapsoriasis. Lichen ; Psychotropic Drugs - therapeutic use ; psychotropic medications ; Risk Factors ; Substance-Related Disorders - drug therapy ; Substance-Related Disorders - epidemiology ; Substance-Related Disorders - psychology ; Suicidal Ideation ; Young Adult</subject><ispartof>Journal of the American Academy of Dermatology, 2012-10, Vol.67 (4), p.651-657.e2</ispartof><rights>American Academy of Dermatology, Inc.</rights><rights>2011 American Academy of Dermatology, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-e5b4e1216677f42364d62b77e9e4738028ea6efd3c10ca66400710a91178847d3</citedby><cites>FETCH-LOGICAL-c441t-e5b4e1216677f42364d62b77e9e4738028ea6efd3c10ca66400710a91178847d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaad.2011.11.948$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26418746$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22243764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kimball, Alexa B., MD</creatorcontrib><creatorcontrib>Wu, Eric Q., PhD</creatorcontrib><creatorcontrib>Guérin, Annie, MSc</creatorcontrib><creatorcontrib>Yu, Andrew P., PhD</creatorcontrib><creatorcontrib>Tsaneva, Magda, BA</creatorcontrib><creatorcontrib>Gupta, Shiraz R., PharmD</creatorcontrib><creatorcontrib>Bao, Yanjun, PhD</creatorcontrib><creatorcontrib>Mulani, Parvez M., PhD</creatorcontrib><title>Risks of developing psychiatric disorders in pediatric patients with psoriasis</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Background Symptoms of psoriasis can be embarrassing and distressing, and may increase risk of developing psychiatric disorders in young people. Objective We sought to compare incidences of psychiatric disorders between pediatric patients with psoriasis and psoriasis-free control subjects. Methods Patients (<18 years) with continuous health plan enrollment 6 months before and after first psoriasis diagnosis (index date) were selected (Thomson Reuters MarketScan database, 2000-2006 [Thomson Reuters, New York, NY]). Patients with psoriasis (N = 7404) were matched 1:5 on age and sex to psoriasis-free control subjects (N = 37,020). Patients were followed from index date to first diagnosis of a psychiatric disorder (ie, alcohol/drug abuse, depression, anxiety disorder, bipolar disorder, suicidal ideation, eating disorder), end of data availability, or disenrollment. Patients with psychiatric diagnoses or psychotropic medication use before the index date were excluded. Cox proportional hazard models controlling for age, sex, and comorbidities were used to estimate the effect of psoriasis on risks of developing psychiatric disorders. Results Patients with psoriasis were significantly more at risk of developing psychiatric disorders versus control subjects (5.13% vs 4.07%; P = .0001; hazard ratio = 1.25; P = .0001), especially depression (3.01% vs 2.42%; P = .0036; hazard ratio = 1.25; P = .0053) and anxiety (1.81% vs 1.35%; P = .0048; hazard ratio = 1.32; P = .0045). Limitations Retrospective, observational studies of medical claims data are typically limited by overall quality and completeness of data and accuracy of coding for diagnoses and procedures. Conclusions Pediatric patients with psoriasis had an increased risk of developing psychiatric disorders, including depression and anxiety, compared with psoriasis-free control subjects.</description><subject>Adolescent</subject><subject>anxiety</subject><subject>Anxiety Disorders - drug therapy</subject><subject>Anxiety Disorders - epidemiology</subject><subject>Anxiety Disorders - psychology</subject><subject>Biological and medical sciences</subject><subject>Bipolar Disorder - drug therapy</subject><subject>Bipolar Disorder - epidemiology</subject><subject>Bipolar Disorder - psychology</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>depression</subject><subject>Depressive Disorder - drug therapy</subject><subject>Depressive Disorder - epidemiology</subject><subject>Depressive Disorder - psychology</subject><subject>Dermatology</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental Disorders - drug therapy</subject><subject>Mental Disorders - epidemiology</subject><subject>pediatrics</subject><subject>Proportional Hazards Models</subject><subject>psoriasis</subject><subject>Psoriasis - epidemiology</subject><subject>Psoriasis - psychology</subject><subject>Psoriasis. Parapsoriasis. Lichen</subject><subject>Psychotropic Drugs - therapeutic use</subject><subject>psychotropic medications</subject><subject>Risk Factors</subject><subject>Substance-Related Disorders - drug therapy</subject><subject>Substance-Related Disorders - epidemiology</subject><subject>Substance-Related Disorders - psychology</subject><subject>Suicidal Ideation</subject><subject>Young Adult</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo7rj6BzxIXwQvPVals0kHRFgWv2BR8OMcMkm1m9me7jbVszL_3jQzKngQChLC81aFp4R4irBGQP1yu956H9cSENelrGrviRWCNbU2rbkvVoAWaqulPBOPmLcAYFVjHoozKWW5aLUSHz8nvuVq7KpId9SPUxq-VxMfwk3yc06hionHHClzlYZqonh6nvycaJi5-pnmmxIYc_Kc-LF40Pme6cnpPBff3r75evW-vv707sPV5XUdlMK5pouNIpSotTGdko1WUcuNMWRJmaYF2ZLX1MUmIASvtQIwCN4imrZVJjbn4sWx75THH3vi2e0SB-p7P9C4Z4egwFptwRZUHtGQR-ZMnZty2vl8KJBbPLqtWzy6xaMrVTyW0LNT__1mR_FP5Le4Ajw_AZ6D77vsh5D4L6cVtkbpwr06clRs3CXKjkMRF4rITGF2cUz__8frf-KhT0MqE2_pQLwd93konh06lg7cl2Xjy8IRQcqLVjW_AHvspPo</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Kimball, Alexa B., MD</creator><creator>Wu, Eric Q., PhD</creator><creator>Guérin, Annie, MSc</creator><creator>Yu, Andrew P., PhD</creator><creator>Tsaneva, Magda, BA</creator><creator>Gupta, Shiraz R., PharmD</creator><creator>Bao, Yanjun, PhD</creator><creator>Mulani, Parvez M., PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121001</creationdate><title>Risks of developing psychiatric disorders in pediatric patients with psoriasis</title><author>Kimball, Alexa B., MD ; Wu, Eric Q., PhD ; Guérin, Annie, MSc ; Yu, Andrew P., PhD ; Tsaneva, Magda, BA ; Gupta, Shiraz R., PharmD ; Bao, Yanjun, PhD ; Mulani, Parvez M., PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-e5b4e1216677f42364d62b77e9e4738028ea6efd3c10ca66400710a91178847d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>anxiety</topic><topic>Anxiety Disorders - drug therapy</topic><topic>Anxiety Disorders - epidemiology</topic><topic>Anxiety Disorders - psychology</topic><topic>Biological and medical sciences</topic><topic>Bipolar Disorder - drug therapy</topic><topic>Bipolar Disorder - epidemiology</topic><topic>Bipolar Disorder - psychology</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>depression</topic><topic>Depressive Disorder - drug therapy</topic><topic>Depressive Disorder - epidemiology</topic><topic>Depressive Disorder - psychology</topic><topic>Dermatology</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental Disorders - drug therapy</topic><topic>Mental Disorders - epidemiology</topic><topic>pediatrics</topic><topic>Proportional Hazards Models</topic><topic>psoriasis</topic><topic>Psoriasis - epidemiology</topic><topic>Psoriasis - psychology</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>Psychotropic Drugs - therapeutic use</topic><topic>psychotropic medications</topic><topic>Risk Factors</topic><topic>Substance-Related Disorders - drug therapy</topic><topic>Substance-Related Disorders - epidemiology</topic><topic>Substance-Related Disorders - psychology</topic><topic>Suicidal Ideation</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kimball, Alexa B., MD</creatorcontrib><creatorcontrib>Wu, Eric Q., PhD</creatorcontrib><creatorcontrib>Guérin, Annie, MSc</creatorcontrib><creatorcontrib>Yu, Andrew P., PhD</creatorcontrib><creatorcontrib>Tsaneva, Magda, BA</creatorcontrib><creatorcontrib>Gupta, Shiraz R., PharmD</creatorcontrib><creatorcontrib>Bao, Yanjun, PhD</creatorcontrib><creatorcontrib>Mulani, Parvez M., PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kimball, Alexa B., MD</au><au>Wu, Eric Q., PhD</au><au>Guérin, Annie, MSc</au><au>Yu, Andrew P., PhD</au><au>Tsaneva, Magda, BA</au><au>Gupta, Shiraz R., PharmD</au><au>Bao, Yanjun, PhD</au><au>Mulani, Parvez M., PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risks of developing psychiatric disorders in pediatric patients with psoriasis</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>67</volume><issue>4</issue><spage>651</spage><epage>657.e2</epage><pages>651-657.e2</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>Background Symptoms of psoriasis can be embarrassing and distressing, and may increase risk of developing psychiatric disorders in young people. Objective We sought to compare incidences of psychiatric disorders between pediatric patients with psoriasis and psoriasis-free control subjects. Methods Patients (<18 years) with continuous health plan enrollment 6 months before and after first psoriasis diagnosis (index date) were selected (Thomson Reuters MarketScan database, 2000-2006 [Thomson Reuters, New York, NY]). Patients with psoriasis (N = 7404) were matched 1:5 on age and sex to psoriasis-free control subjects (N = 37,020). Patients were followed from index date to first diagnosis of a psychiatric disorder (ie, alcohol/drug abuse, depression, anxiety disorder, bipolar disorder, suicidal ideation, eating disorder), end of data availability, or disenrollment. Patients with psychiatric diagnoses or psychotropic medication use before the index date were excluded. Cox proportional hazard models controlling for age, sex, and comorbidities were used to estimate the effect of psoriasis on risks of developing psychiatric disorders. Results Patients with psoriasis were significantly more at risk of developing psychiatric disorders versus control subjects (5.13% vs 4.07%; P = .0001; hazard ratio = 1.25; P = .0001), especially depression (3.01% vs 2.42%; P = .0036; hazard ratio = 1.25; P = .0053) and anxiety (1.81% vs 1.35%; P = .0048; hazard ratio = 1.32; P = .0045). Limitations Retrospective, observational studies of medical claims data are typically limited by overall quality and completeness of data and accuracy of coding for diagnoses and procedures. Conclusions Pediatric patients with psoriasis had an increased risk of developing psychiatric disorders, including depression and anxiety, compared with psoriasis-free control subjects.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>22243764</pmid><doi>10.1016/j.jaad.2011.11.948</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent anxiety Anxiety Disorders - drug therapy Anxiety Disorders - epidemiology Anxiety Disorders - psychology Biological and medical sciences Bipolar Disorder - drug therapy Bipolar Disorder - epidemiology Bipolar Disorder - psychology Cohort Studies Comorbidity depression Depressive Disorder - drug therapy Depressive Disorder - epidemiology Depressive Disorder - psychology Dermatology Female General aspects Humans Incidence Male Medical sciences Mental Disorders - drug therapy Mental Disorders - epidemiology pediatrics Proportional Hazards Models psoriasis Psoriasis - epidemiology Psoriasis - psychology Psoriasis. Parapsoriasis. Lichen Psychotropic Drugs - therapeutic use psychotropic medications Risk Factors Substance-Related Disorders - drug therapy Substance-Related Disorders - epidemiology Substance-Related Disorders - psychology Suicidal Ideation Young Adult |
| title | Risks of developing psychiatric disorders in pediatric patients with psoriasis |
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