Effect of immunosuppressive drugs on spontaneous DNA repair in human peripheral blood mononuclear cells

Abstract Introduction Immunosuppressive treatment increases the risk of post-transplant cancer. Cyclosporine reduced UV-induced DNA repair by peripheral blood mononuclear cells (PBMC) and increased cancer incidence in kidney transplant recipients. Calcineurin inhibitors (CNI), but not mammalian targ...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2012-09, Vol.66 (6), p.409-413
Hauptverfasser:	Ori, Yaacov, Herman-Edelstein, Michal, Zingerman, Boris, Rozen-Zvi, Benaya, Gafter, Uzi, Malachi, Tsipora, Gafter-Gvili, Anat
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Blood Banks Calcineurin - metabolism Calcineurin inhibitor Calcineurin Inhibitors Carcinogenicity Tests Cyclosporine - adverse effects Cyclosporine - pharmacology DNA repair DNA Repair - drug effects Enzyme Inhibitors - adverse effects Enzyme Inhibitors - pharmacology Everolimus Humans Immunosuppressive Agents - adverse effects Immunosuppressive Agents - pharmacology Immunosuppressive drugs Internal Medicine Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Medical Education mTOR inhibitor Mycophenolic acid Mycophenolic Acid - adverse effects Mycophenolic Acid - pharmacology Osmolar Concentration Sirolimus - adverse effects Sirolimus - analogs & derivatives Sirolimus - pharmacology Tacrolimus - adverse effects Tacrolimus - pharmacology TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism
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