14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: a randomised trial

Summary Background New drugs, but also shorter, better-tolerated regimens are needed to tackle the high global burden of tuberculosis complicated by drug resistance and retroviral disease. We investigated new multiple-agent combinations over the first 14 days of treatment to assess their suitability...

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Veröffentlicht in:	The Lancet (British edition) 2012-09, Vol.380 (9846), p.986-993
Hauptverfasser:	Diacon, Andreas H, Prof, Dawson, Rodney, MD, von Groote-Bidlingmaier, Florian, MD, Symons, Gregory, MBChB, Venter, Amour, NatDipTech, Donald, Peter R, Prof, van Niekerk, Christo, MD, Everitt, Daniel, MD, Winter, Helen, PhD, Becker, Piet, PhD, Mendel, Carl M, MD, Spigelman, Melvin K, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult analysis of variance Antibacterial agents antibacterial properties Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents - adverse effects Antitubercular Agents - therapeutic use Aza Compounds - adverse effects Aza Compounds - therapeutic use Biological and medical sciences Colony Count, Microbial Diarylquinolines Double-Blind Method Drug Therapy, Combination Female Fluoroquinolones General aspects hospitals human resources Humans Internal Medicine Male Medical sciences Microbial Viability - drug effects Moxifloxacin multiple drug resistance Mycobacterium tuberculosis Mycobacterium tuberculosis - growth & development new drugs Nitroimidazoles - adverse effects Nitroimidazoles - therapeutic use patients Pharmacology. Drug treatments Prospective Studies Pyrazinamide - adverse effects Pyrazinamide - therapeutic use Quinolines - adverse effects Quinolines - therapeutic use Sputum - microbiology tuberculosis Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - microbiology Young Adult
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