Participation of endoplasmic reticulum stress in the pathogenesis of spontaneous glomerulosclerosis–Role of intra-renal angiotensin system

Endoplasmic reticulum (ER) is the site of synthesis, folding, assembly, and degradation of proteins. Disruption of ER function leads to ER stress, which is marked by accumulation of unfolded proteins in the ER lumen. Detection of unfolded proteins by the ER membrane receptors triggers the “unfolded...

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Veröffentlicht in:	Translational research : the journal of laboratory and clinical medicine 2012-10, Vol.160 (4), p.309-318
Hauptverfasser:	Aminzadeh, Mohammad A, Sato, Tadashi, Vaziri, Nosratola D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Angiotensins - metabolism Animals Apoptosis Autophagy Endoplasmic Reticulum - metabolism Gene Expression Regulation - physiology Glomerulosclerosis, Focal Segmental - metabolism Internal Medicine Kidney - physiology Male Rats Rats, Sprague-Dawley Stress, Physiological
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