Comparative Study on the Inhibitory Effects of α-Tocopherol and Radon on Carbon Tetrachloride-Induced Renal Damage
Since the 2011 nuclear accident in Fukushima, the effects of low-dose irradiation, especially internal exposure, are at the forefront of everyone's attention. However, low-dose radiation induced various stimulating effects such as activation of antioxidative and immune functions. In this study,...
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| Veröffentlicht in: | Renal failure 2012-01, Vol.34 (9), p.1181-1187 |
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| creator | Kataoka, Takahiro Yamato, Keiko Nishiyama, Yuichi Morii, Yuji Etani, Reo Takata, Yuji Hanamoto, Katsumi Kawabe, Atsuishi Sakoda, Akihiro Ishimori, Yuu Taguchi, Takehito Yamaoka, Kiyonori |
| description | Since the 2011 nuclear accident in Fukushima, the effects of low-dose irradiation, especially internal exposure, are at the forefront of everyone's attention. However, low-dose radiation induced various stimulating effects such as activation of antioxidative and immune functions. In this study, we attempted to evaluate the quantitative effects of the activation of antioxidative activities in kidney induced by radon inhalation on carbon tetrachloride (CCl4)-induced renal damage. Mice were subjected to intraperitoneal (i.p.) injection of CCl4 after inhaling approximately 1000 or 2000 Bq/m3 radon for 24 h, or immediately after i.p. injection of α-tocopherol (100, 300, or 500 mg/kg bodyweight). In case of renal function, radon inhalation at a concentration of 2000 Bq/m3 has the inhibitory effects similar to α-tocopherol treatment at a dose of 300-500 mg/kg bodyweight. The activities of superoxide dismutase and catalase in kidneys were significantly higher in mice exposed to radon as compared to mice treated with CCl4 alone. These findings suggest that radon inhalation has an antioxidative effect against CCl4-induced renal damage similar to the antioxidative effects of α-tocopherol due to induction of antioxidative functions. |
| doi_str_mv | 10.3109/0886022X.2012.717496 |
| format | Article |
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However, low-dose radiation induced various stimulating effects such as activation of antioxidative and immune functions. In this study, we attempted to evaluate the quantitative effects of the activation of antioxidative activities in kidney induced by radon inhalation on carbon tetrachloride (CCl4)-induced renal damage. Mice were subjected to intraperitoneal (i.p.) injection of CCl4 after inhaling approximately 1000 or 2000 Bq/m3 radon for 24 h, or immediately after i.p. injection of α-tocopherol (100, 300, or 500 mg/kg bodyweight). In case of renal function, radon inhalation at a concentration of 2000 Bq/m3 has the inhibitory effects similar to α-tocopherol treatment at a dose of 300-500 mg/kg bodyweight. The activities of superoxide dismutase and catalase in kidneys were significantly higher in mice exposed to radon as compared to mice treated with CCl4 alone. These findings suggest that radon inhalation has an antioxidative effect against CCl4-induced renal damage similar to the antioxidative effects of α-tocopherol due to induction of antioxidative functions.</description><identifier>ISSN: 0886-022X</identifier><identifier>EISSN: 1525-6049</identifier><identifier>DOI: 10.3109/0886022X.2012.717496</identifier><identifier>PMID: 22978362</identifier><language>eng</language><publisher>England: Informa Healthcare</publisher><subject>Acute Kidney Injury - etiology ; Acute Kidney Injury - pathology ; Acute Kidney Injury - prevention & control ; alpha-Tocopherol - therapeutic use ; Animals ; Antioxidants - therapeutic use ; Carbon Tetrachloride - toxicity ; Carbon Tetrachloride Poisoning - complications ; Carbon Tetrachloride Poisoning - drug therapy ; Carbon Tetrachloride Poisoning - pathology ; Disease Models, Animal ; Female ; Glomerular Filtration Rate - drug effects ; Kidney - drug effects ; Kidney - pathology ; Kidney - physiopathology ; Mice ; Mice, Inbred ICR ; Radon - therapeutic use ; Treatment Outcome</subject><ispartof>Renal failure, 2012-01, Vol.34 (9), p.1181-1187</ispartof><rights>2012 Informa Healthcare USA, Inc. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-d8d9d6c54a97d365d7c43d88be26c1de300cb91efcdef87d893619192de7cf0e3</citedby><cites>FETCH-LOGICAL-c452t-d8d9d6c54a97d365d7c43d88be26c1de300cb91efcdef87d893619192de7cf0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22978362$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kataoka, Takahiro</creatorcontrib><creatorcontrib>Yamato, Keiko</creatorcontrib><creatorcontrib>Nishiyama, Yuichi</creatorcontrib><creatorcontrib>Morii, Yuji</creatorcontrib><creatorcontrib>Etani, Reo</creatorcontrib><creatorcontrib>Takata, Yuji</creatorcontrib><creatorcontrib>Hanamoto, Katsumi</creatorcontrib><creatorcontrib>Kawabe, Atsuishi</creatorcontrib><creatorcontrib>Sakoda, Akihiro</creatorcontrib><creatorcontrib>Ishimori, Yuu</creatorcontrib><creatorcontrib>Taguchi, Takehito</creatorcontrib><creatorcontrib>Yamaoka, Kiyonori</creatorcontrib><title>Comparative Study on the Inhibitory Effects of α-Tocopherol and Radon on Carbon Tetrachloride-Induced Renal Damage</title><title>Renal failure</title><addtitle>Ren Fail</addtitle><description>Since the 2011 nuclear accident in Fukushima, the effects of low-dose irradiation, especially internal exposure, are at the forefront of everyone's attention. However, low-dose radiation induced various stimulating effects such as activation of antioxidative and immune functions. In this study, we attempted to evaluate the quantitative effects of the activation of antioxidative activities in kidney induced by radon inhalation on carbon tetrachloride (CCl4)-induced renal damage. Mice were subjected to intraperitoneal (i.p.) injection of CCl4 after inhaling approximately 1000 or 2000 Bq/m3 radon for 24 h, or immediately after i.p. injection of α-tocopherol (100, 300, or 500 mg/kg bodyweight). In case of renal function, radon inhalation at a concentration of 2000 Bq/m3 has the inhibitory effects similar to α-tocopherol treatment at a dose of 300-500 mg/kg bodyweight. The activities of superoxide dismutase and catalase in kidneys were significantly higher in mice exposed to radon as compared to mice treated with CCl4 alone. These findings suggest that radon inhalation has an antioxidative effect against CCl4-induced renal damage similar to the antioxidative effects of α-tocopherol due to induction of antioxidative functions.</description><subject>Acute Kidney Injury - etiology</subject><subject>Acute Kidney Injury - pathology</subject><subject>Acute Kidney Injury - prevention & control</subject><subject>alpha-Tocopherol - therapeutic use</subject><subject>Animals</subject><subject>Antioxidants - therapeutic use</subject><subject>Carbon Tetrachloride - toxicity</subject><subject>Carbon Tetrachloride Poisoning - complications</subject><subject>Carbon Tetrachloride Poisoning - drug therapy</subject><subject>Carbon Tetrachloride Poisoning - pathology</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Glomerular Filtration Rate - drug effects</subject><subject>Kidney - drug effects</subject><subject>Kidney - pathology</subject><subject>Kidney - physiopathology</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Radon - therapeutic use</subject><subject>Treatment Outcome</subject><issn>0886-022X</issn><issn>1525-6049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1q2zAYhsVoWdKsdzCGDnviVJJtWToZlKw_gcJgy6BnRpY-zS62lUryIJe1G-k1VSFJDwsfvCfP-73wIPSVkmVOibwmQnDC2NOSEcqWFa0KyT-hOS1ZmXFSyDM03yPZnpmhixCeCaGlqNhnNGNMViLnbI7Cyg1b5VXs_gH-HSezw27EsQW8Htuu6aLzO3xrLegYsLP49X-2cdptW_Cux2o0-JcyqZFupXyTYgPRK932zncGsvVoJg2JglH1-Ica1F_4gs6t6gNcHnOB_tzdblYP2ePP-_Xq5jHTRcliZoSRhuuyULIyOS9NpYvcCNEA45oayAnRjaRgtQErKiNkzqmkkhmotCWQL9DV4e_Wu5cJQqyHLmjoezWCm0JNSUGk5CSnCS0OqPYuBA-23vpuUH6XoHqvuz7prve664PuVPt2XJiaAcx76eQ3Ad8PQDda5wfVgupjq5WH-tlNPjkJHy-8AWzFkL0</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Kataoka, Takahiro</creator><creator>Yamato, Keiko</creator><creator>Nishiyama, Yuichi</creator><creator>Morii, Yuji</creator><creator>Etani, Reo</creator><creator>Takata, Yuji</creator><creator>Hanamoto, Katsumi</creator><creator>Kawabe, Atsuishi</creator><creator>Sakoda, Akihiro</creator><creator>Ishimori, Yuu</creator><creator>Taguchi, Takehito</creator><creator>Yamaoka, Kiyonori</creator><general>Informa Healthcare</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120101</creationdate><title>Comparative Study on the Inhibitory Effects of α-Tocopherol and Radon on Carbon Tetrachloride-Induced Renal Damage</title><author>Kataoka, Takahiro ; Yamato, Keiko ; Nishiyama, Yuichi ; Morii, Yuji ; Etani, Reo ; Takata, Yuji ; Hanamoto, Katsumi ; Kawabe, Atsuishi ; Sakoda, Akihiro ; Ishimori, Yuu ; Taguchi, Takehito ; Yamaoka, Kiyonori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-d8d9d6c54a97d365d7c43d88be26c1de300cb91efcdef87d893619192de7cf0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acute Kidney Injury - etiology</topic><topic>Acute Kidney Injury - pathology</topic><topic>Acute Kidney Injury - prevention & control</topic><topic>alpha-Tocopherol - therapeutic use</topic><topic>Animals</topic><topic>Antioxidants - therapeutic use</topic><topic>Carbon Tetrachloride - toxicity</topic><topic>Carbon Tetrachloride Poisoning - complications</topic><topic>Carbon Tetrachloride Poisoning - drug therapy</topic><topic>Carbon Tetrachloride Poisoning - pathology</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Glomerular Filtration Rate - drug effects</topic><topic>Kidney - drug effects</topic><topic>Kidney - pathology</topic><topic>Kidney - physiopathology</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Radon - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kataoka, Takahiro</creatorcontrib><creatorcontrib>Yamato, Keiko</creatorcontrib><creatorcontrib>Nishiyama, Yuichi</creatorcontrib><creatorcontrib>Morii, Yuji</creatorcontrib><creatorcontrib>Etani, Reo</creatorcontrib><creatorcontrib>Takata, Yuji</creatorcontrib><creatorcontrib>Hanamoto, Katsumi</creatorcontrib><creatorcontrib>Kawabe, Atsuishi</creatorcontrib><creatorcontrib>Sakoda, Akihiro</creatorcontrib><creatorcontrib>Ishimori, Yuu</creatorcontrib><creatorcontrib>Taguchi, Takehito</creatorcontrib><creatorcontrib>Yamaoka, Kiyonori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Renal failure</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kataoka, Takahiro</au><au>Yamato, Keiko</au><au>Nishiyama, Yuichi</au><au>Morii, Yuji</au><au>Etani, Reo</au><au>Takata, Yuji</au><au>Hanamoto, Katsumi</au><au>Kawabe, Atsuishi</au><au>Sakoda, Akihiro</au><au>Ishimori, Yuu</au><au>Taguchi, Takehito</au><au>Yamaoka, Kiyonori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative Study on the Inhibitory Effects of α-Tocopherol and Radon on Carbon Tetrachloride-Induced Renal Damage</atitle><jtitle>Renal failure</jtitle><addtitle>Ren Fail</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>34</volume><issue>9</issue><spage>1181</spage><epage>1187</epage><pages>1181-1187</pages><issn>0886-022X</issn><eissn>1525-6049</eissn><abstract>Since the 2011 nuclear accident in Fukushima, the effects of low-dose irradiation, especially internal exposure, are at the forefront of everyone's attention. However, low-dose radiation induced various stimulating effects such as activation of antioxidative and immune functions. In this study, we attempted to evaluate the quantitative effects of the activation of antioxidative activities in kidney induced by radon inhalation on carbon tetrachloride (CCl4)-induced renal damage. Mice were subjected to intraperitoneal (i.p.) injection of CCl4 after inhaling approximately 1000 or 2000 Bq/m3 radon for 24 h, or immediately after i.p. injection of α-tocopherol (100, 300, or 500 mg/kg bodyweight). In case of renal function, radon inhalation at a concentration of 2000 Bq/m3 has the inhibitory effects similar to α-tocopherol treatment at a dose of 300-500 mg/kg bodyweight. The activities of superoxide dismutase and catalase in kidneys were significantly higher in mice exposed to radon as compared to mice treated with CCl4 alone. 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| ispartof | Renal failure, 2012-01, Vol.34 (9), p.1181-1187 |
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| subjects | Acute Kidney Injury - etiology Acute Kidney Injury - pathology Acute Kidney Injury - prevention & control alpha-Tocopherol - therapeutic use Animals Antioxidants - therapeutic use Carbon Tetrachloride - toxicity Carbon Tetrachloride Poisoning - complications Carbon Tetrachloride Poisoning - drug therapy Carbon Tetrachloride Poisoning - pathology Disease Models, Animal Female Glomerular Filtration Rate - drug effects Kidney - drug effects Kidney - pathology Kidney - physiopathology Mice Mice, Inbred ICR Radon - therapeutic use Treatment Outcome |
| title | Comparative Study on the Inhibitory Effects of α-Tocopherol and Radon on Carbon Tetrachloride-Induced Renal Damage |
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