Radiological evaluation of the effect of biphasic calcium phosphate scaffold (HA+TCP) with 5, 10 and 20 percentage of porosity on healing of segmental bone defect in rabbit radius
The objective of this study is to radiologically evaluate the effects of biphasic calcium phosphate scaffold with 5, 10 and 20 percentage of porosity on cortical bone repair in rabbits. In this study, 28 male white rabbits were examined. Rabbits were divided into four groups. After induction of gene...
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| Veröffentlicht in: | Bratislava Medical Journal 2012, Vol.113 (9), p.529-533 |
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| creator | Farahpour, M R Sharifi, D B, A A Veshkini, A Soheil, A |
| description | The objective of this study is to radiologically evaluate the effects of biphasic calcium phosphate scaffold with 5, 10 and 20 percentage of porosity on cortical bone repair in rabbits. In this study, 28 male white rabbits were examined. Rabbits were divided into four groups. After induction of general anesthesia, a segmental bone defect of 10 mm in length was created in the middle of the right radius shaft. In group A, the defect was stabilized with miniplate and 2 screws and left untreated. In groups B, C and D tricalcium phosphate scaffold mixed with hydroxyapatite (TCP+HA) with 5%, 10% and 20% porosity was used to fi ll the bone defect. Bone regeneration and HA+TCP scaffold resorption were assessed by X-ray at 1, 2 and 3 months after the surgery. In group A, 3 months after surgery, periosteal callus was not found but intercortical callus was observed. In groups B and C, 3 months after surgery medullary bridging callus and intercortical callus were found, periosteal callus was not found, TCP+HA scaffold were observed. In group D, 2 months after the surgery, medullary bridging callus and intercortical callus were found, 3 months later, periosteal callus was not found, most of scaffold had disappeared and were unclear and partial bone formation was recognized. Differences observed in radiological findings were significant between group A and groups B, C, D. Differences between groups B and C were not significant, but between group D and groups B and C were significant. The results of this study showed that TCP+HA scaffold is an osteoconductive and osteoinductive biomaterial. Scaffold of TCP+HA can increase the amount of newly formed bone and more rapid regeneration of bone defects. These results suggest TCP+HA scaffold may considerably be used in the treatment of cortical bone defect and other orthopaedic defects PCL (Tab. 2, Fig. 4, Ref. 20). |
| doi_str_mv | 10.4149/BLL_2012_119 |
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In this study, 28 male white rabbits were examined. Rabbits were divided into four groups. After induction of general anesthesia, a segmental bone defect of 10 mm in length was created in the middle of the right radius shaft. In group A, the defect was stabilized with miniplate and 2 screws and left untreated. In groups B, C and D tricalcium phosphate scaffold mixed with hydroxyapatite (TCP+HA) with 5%, 10% and 20% porosity was used to fi ll the bone defect. Bone regeneration and HA+TCP scaffold resorption were assessed by X-ray at 1, 2 and 3 months after the surgery. In group A, 3 months after surgery, periosteal callus was not found but intercortical callus was observed. In groups B and C, 3 months after surgery medullary bridging callus and intercortical callus were found, periosteal callus was not found, TCP+HA scaffold were observed. In group D, 2 months after the surgery, medullary bridging callus and intercortical callus were found, 3 months later, periosteal callus was not found, most of scaffold had disappeared and were unclear and partial bone formation was recognized. Differences observed in radiological findings were significant between group A and groups B, C, D. Differences between groups B and C were not significant, but between group D and groups B and C were significant. The results of this study showed that TCP+HA scaffold is an osteoconductive and osteoinductive biomaterial. Scaffold of TCP+HA can increase the amount of newly formed bone and more rapid regeneration of bone defects. These results suggest TCP+HA scaffold may considerably be used in the treatment of cortical bone defect and other orthopaedic defects PCL (Tab. 2, Fig. 4, Ref. 20).</description><identifier>ISSN: 0006-9248</identifier><identifier>ISSN: 1336-0345</identifier><identifier>EISSN: 1336-0345</identifier><identifier>DOI: 10.4149/BLL_2012_119</identifier><identifier>PMID: 22979907</identifier><language>eng</language><publisher>Slovakia</publisher><subject>Animals ; Bone Regeneration - drug effects ; Bony Callus - pathology ; Hydroxyapatites - therapeutic use ; Male ; Porosity ; Prostheses and Implants ; Rabbits ; Radiography ; Radius - diagnostic imaging ; Radius - injuries ; Tissue Scaffolds</subject><ispartof>Bratislava Medical Journal, 2012, Vol.113 (9), p.529-533</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-b194d6e5e2b2f060a83ec986202d0a846e4af66d6cbb5651e8c213e66979ed3d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22979907$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farahpour, M R</creatorcontrib><creatorcontrib>Sharifi, D</creatorcontrib><creatorcontrib>B, A A</creatorcontrib><creatorcontrib>Veshkini, A</creatorcontrib><creatorcontrib>Soheil, A</creatorcontrib><title>Radiological evaluation of the effect of biphasic calcium phosphate scaffold (HA+TCP) with 5, 10 and 20 percentage of porosity on healing of segmental bone defect in rabbit radius</title><title>Bratislava Medical Journal</title><addtitle>Bratisl Lek Listy</addtitle><description>The objective of this study is to radiologically evaluate the effects of biphasic calcium phosphate scaffold with 5, 10 and 20 percentage of porosity on cortical bone repair in rabbits. In this study, 28 male white rabbits were examined. Rabbits were divided into four groups. After induction of general anesthesia, a segmental bone defect of 10 mm in length was created in the middle of the right radius shaft. In group A, the defect was stabilized with miniplate and 2 screws and left untreated. In groups B, C and D tricalcium phosphate scaffold mixed with hydroxyapatite (TCP+HA) with 5%, 10% and 20% porosity was used to fi ll the bone defect. Bone regeneration and HA+TCP scaffold resorption were assessed by X-ray at 1, 2 and 3 months after the surgery. In group A, 3 months after surgery, periosteal callus was not found but intercortical callus was observed. In groups B and C, 3 months after surgery medullary bridging callus and intercortical callus were found, periosteal callus was not found, TCP+HA scaffold were observed. In group D, 2 months after the surgery, medullary bridging callus and intercortical callus were found, 3 months later, periosteal callus was not found, most of scaffold had disappeared and were unclear and partial bone formation was recognized. Differences observed in radiological findings were significant between group A and groups B, C, D. Differences between groups B and C were not significant, but between group D and groups B and C were significant. The results of this study showed that TCP+HA scaffold is an osteoconductive and osteoinductive biomaterial. Scaffold of TCP+HA can increase the amount of newly formed bone and more rapid regeneration of bone defects. These results suggest TCP+HA scaffold may considerably be used in the treatment of cortical bone defect and other orthopaedic defects PCL (Tab. 2, Fig. 4, Ref. 20).</description><subject>Animals</subject><subject>Bone Regeneration - drug effects</subject><subject>Bony Callus - pathology</subject><subject>Hydroxyapatites - therapeutic use</subject><subject>Male</subject><subject>Porosity</subject><subject>Prostheses and Implants</subject><subject>Rabbits</subject><subject>Radiography</subject><subject>Radius - diagnostic imaging</subject><subject>Radius - injuries</subject><subject>Tissue Scaffolds</subject><issn>0006-9248</issn><issn>1336-0345</issn><issn>1336-0345</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkUtv1TAQhS0EoreFHWvkZVEb8Cvu9bJcAa10JRAq68iP8Y2RE4fYAfV39Q_WoQV1dTRHn85o5iD0hpL3ggr14eN-3zFCWUepeoY2lHPZEC7a52hDCJGNYmJ7hI5z_kmI4C2VL9ERY-pCKXKxQXfftQsppkOwOmL4reOiS0gjTh6XHjB4D7askwlTr3OwuII2LAOe-pSrVQBnq71P0eHTq8uzm923d_hPKD1uzzElWI8OM4InmC2MRR9gDZvSnHIot7hu6kHHMB5WO8NhWKGITRoBO_i7PIx41saEUsWFJb9CL7yOGV4_6gn68fnTze6q2X_9cr273DeWS1YaQ5VwElpghnkiid5ysGorGWGuDkKC0F5KJ60xrWwpbC2jHKSsvwHHHT9Bpw-505x-LZBLN4RsIUY9QlpyR4kgSgkqSUXPH1Bb78oz-G6aw6Dn2wp1a03d05oq_vYxeTEDuP_wv174PVsvjnE</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Farahpour, M R</creator><creator>Sharifi, D</creator><creator>B, A A</creator><creator>Veshkini, A</creator><creator>Soheil, A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>Radiological evaluation of the effect of biphasic calcium phosphate scaffold (HA+TCP) with 5, 10 and 20 percentage of porosity on healing of segmental bone defect in rabbit radius</title><author>Farahpour, M R ; Sharifi, D ; B, A A ; Veshkini, A ; Soheil, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-b194d6e5e2b2f060a83ec986202d0a846e4af66d6cbb5651e8c213e66979ed3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Bone Regeneration - drug effects</topic><topic>Bony Callus - pathology</topic><topic>Hydroxyapatites - therapeutic use</topic><topic>Male</topic><topic>Porosity</topic><topic>Prostheses and Implants</topic><topic>Rabbits</topic><topic>Radiography</topic><topic>Radius - diagnostic imaging</topic><topic>Radius - injuries</topic><topic>Tissue Scaffolds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farahpour, M R</creatorcontrib><creatorcontrib>Sharifi, D</creatorcontrib><creatorcontrib>B, A A</creatorcontrib><creatorcontrib>Veshkini, A</creatorcontrib><creatorcontrib>Soheil, A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bratislava Medical Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farahpour, M R</au><au>Sharifi, D</au><au>B, A A</au><au>Veshkini, A</au><au>Soheil, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiological evaluation of the effect of biphasic calcium phosphate scaffold (HA+TCP) with 5, 10 and 20 percentage of porosity on healing of segmental bone defect in rabbit radius</atitle><jtitle>Bratislava Medical Journal</jtitle><addtitle>Bratisl Lek Listy</addtitle><date>2012</date><risdate>2012</risdate><volume>113</volume><issue>9</issue><spage>529</spage><epage>533</epage><pages>529-533</pages><issn>0006-9248</issn><issn>1336-0345</issn><eissn>1336-0345</eissn><abstract>The objective of this study is to radiologically evaluate the effects of biphasic calcium phosphate scaffold with 5, 10 and 20 percentage of porosity on cortical bone repair in rabbits. In this study, 28 male white rabbits were examined. Rabbits were divided into four groups. After induction of general anesthesia, a segmental bone defect of 10 mm in length was created in the middle of the right radius shaft. In group A, the defect was stabilized with miniplate and 2 screws and left untreated. In groups B, C and D tricalcium phosphate scaffold mixed with hydroxyapatite (TCP+HA) with 5%, 10% and 20% porosity was used to fi ll the bone defect. Bone regeneration and HA+TCP scaffold resorption were assessed by X-ray at 1, 2 and 3 months after the surgery. In group A, 3 months after surgery, periosteal callus was not found but intercortical callus was observed. In groups B and C, 3 months after surgery medullary bridging callus and intercortical callus were found, periosteal callus was not found, TCP+HA scaffold were observed. In group D, 2 months after the surgery, medullary bridging callus and intercortical callus were found, 3 months later, periosteal callus was not found, most of scaffold had disappeared and were unclear and partial bone formation was recognized. Differences observed in radiological findings were significant between group A and groups B, C, D. Differences between groups B and C were not significant, but between group D and groups B and C were significant. The results of this study showed that TCP+HA scaffold is an osteoconductive and osteoinductive biomaterial. Scaffold of TCP+HA can increase the amount of newly formed bone and more rapid regeneration of bone defects. These results suggest TCP+HA scaffold may considerably be used in the treatment of cortical bone defect and other orthopaedic defects PCL (Tab. 2, Fig. 4, Ref. 20).</abstract><cop>Slovakia</cop><pmid>22979907</pmid><doi>10.4149/BLL_2012_119</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Bone Regeneration - drug effects Bony Callus - pathology Hydroxyapatites - therapeutic use Male Porosity Prostheses and Implants Rabbits Radiography Radius - diagnostic imaging Radius - injuries Tissue Scaffolds |
| title | Radiological evaluation of the effect of biphasic calcium phosphate scaffold (HA+TCP) with 5, 10 and 20 percentage of porosity on healing of segmental bone defect in rabbit radius |
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