Defective intestinal amino acid absorption in Ace2 null mice

Mutations in the main intestinal and kidney luminal neutral amino acid transporter B(0)AT1 (Slc6a19) lead to Hartnup disorder, a condition that is characterized by neutral aminoaciduria and in some cases pellagra-like symptoms. These latter symptoms caused by low-niacin are thought to result from de...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2012-09, Vol.303 (6), p.G686-G695
Hauptverfasser:	Singer, Dustin, Camargo, Simone M R, Ramadan, Tamara, Schäfer, Matthias, Mariotta, Luca, Herzog, Brigitte, Huggel, Katja, Wolfer, David, Werner, Sabine, Penninger, Josef M, Verrey, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption - physiology Amino Acid Transport Systems, Neutral - genetics Amino Acid Transport Systems, Neutral - metabolism Amino acids Amino Acids - metabolism Animal Nutritional Physiological Phenomena Animals Diet Dietary Proteins - administration & dosage Gene Expression Regulation - physiology Genotype Homeostasis Intestines - metabolism Male Measurement Mice Mice, Knockout Mutation Niacin - metabolism Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism Plasma Proteins Rodents Time Factors
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