Effects of Statin Therapy on the Production of Monocyte Pro-Inflammatory Cytokines, Cardiac Function, and Long-Term Prognosis in Chronic Heart Failure Patients With Dyslipidemia
Background: The effects of statin therapy on the production of monocyte pro-inflammatory cytokines, cardiac function and the long-term prognosis in chronic heart failure (CHF) patients with dyslipidemia remain unclear. Methods and Results: A total of 146 CHF patients with a mean left ventricular eje...
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| Veröffentlicht in: | Circulation Journal 2012, Vol.76(9), pp.2130-2138 |
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| creator | Nakagomi, Akihiro Seino, Yoshihiko Kohashi, Keiichi Kosugi, Munenori Endoh, Yasumi Kusama, Yoshiki Atarashi, Hirotsugu Mizuno, Kyoichi |
| description | Background: The effects of statin therapy on the production of monocyte pro-inflammatory cytokines, cardiac function and the long-term prognosis in chronic heart failure (CHF) patients with dyslipidemia remain unclear. Methods and Results: A total of 146 CHF patients with a mean left ventricular ejection fraction (LVEF) of 26.9±6.6% were divided into 2 groups based on whether or not statins were included in their treatment: a statin group (n=63) and a no statin group (n=83). Only patients with dyslipidemia were treated with statins. Peripheral blood mononuclear cells (PBMCs) were isolated, and the production of monocyte tumor necrosis factor (TNF)-α and interleukin (IL)-6 were measured at baseline and after 6 months of treatment, and the data expressed as mean±SD (pg·ml–1·10–6 PBMCs). The LVEF in the statin group improved, and the monocyte TNF-α and IL-6 production decreased (respectively, P |
| doi_str_mv | 10.1253/circj.CJ-11-1123 |
| format | Article |
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Methods and Results: A total of 146 CHF patients with a mean left ventricular ejection fraction (LVEF) of 26.9±6.6% were divided into 2 groups based on whether or not statins were included in their treatment: a statin group (n=63) and a no statin group (n=83). Only patients with dyslipidemia were treated with statins. Peripheral blood mononuclear cells (PBMCs) were isolated, and the production of monocyte tumor necrosis factor (TNF)-α and interleukin (IL)-6 were measured at baseline and after 6 months of treatment, and the data expressed as mean±SD (pg·ml–1·10–6 PBMCs). The LVEF in the statin group improved, and the monocyte TNF-α and IL-6 production decreased (respectively, P<0.001), but the LVEF and cytokine production remained unchanged in the no statin group. Multivariate Cox hazard analysis showed that statin therapy (hazard ratio, 0.14; 95% confidence interval: 0.02–0.97, P=0.046) was an independent predictor of cardiac events. Conclusions: Statin therapy attenuates the production of monocyte pro-inflammatory cytokines, and ameliorates the cardiac function and may improve long-term prognosis in CHF patients with dyslipidemia. (Circ J 2012; 76: 2130–2138)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-11-1123</identifier><identifier>PMID: 22785006</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Aged ; Chronic Disease ; Cytokine ; Dyslipidemia ; Dyslipidemias - blood ; Dyslipidemias - complications ; Dyslipidemias - diagnosis ; Dyslipidemias - drug therapy ; Dyslipidemias - pathology ; Dyslipidemias - physiopathology ; Female ; Heart failure ; Heart Failure - blood ; Heart Failure - complications ; Heart Failure - diagnosis ; Heart Failure - drug therapy ; Heart Failure - pathology ; Heart Failure - physiopathology ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage ; Inflammation Mediators - blood ; Interleukin-6 - blood ; Male ; Middle Aged ; Monocytes - metabolism ; Monocytes - pathology ; Prognosis ; Statin ; Stroke Volume ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>Circulation Journal, 2012, Vol.76(9), pp.2130-2138</ispartof><rights>2012 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-87741a45cab96e06b8d8f3812351932a9398028e895fb8488cf9fca1bb44d0c93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22785006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakagomi, Akihiro</creatorcontrib><creatorcontrib>Seino, Yoshihiko</creatorcontrib><creatorcontrib>Kohashi, Keiichi</creatorcontrib><creatorcontrib>Kosugi, Munenori</creatorcontrib><creatorcontrib>Endoh, Yasumi</creatorcontrib><creatorcontrib>Kusama, Yoshiki</creatorcontrib><creatorcontrib>Atarashi, Hirotsugu</creatorcontrib><creatorcontrib>Mizuno, Kyoichi</creatorcontrib><title>Effects of Statin Therapy on the Production of Monocyte Pro-Inflammatory Cytokines, Cardiac Function, and Long-Term Prognosis in Chronic Heart Failure Patients With Dyslipidemia</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background: The effects of statin therapy on the production of monocyte pro-inflammatory cytokines, cardiac function and the long-term prognosis in chronic heart failure (CHF) patients with dyslipidemia remain unclear. Methods and Results: A total of 146 CHF patients with a mean left ventricular ejection fraction (LVEF) of 26.9±6.6% were divided into 2 groups based on whether or not statins were included in their treatment: a statin group (n=63) and a no statin group (n=83). Only patients with dyslipidemia were treated with statins. Peripheral blood mononuclear cells (PBMCs) were isolated, and the production of monocyte tumor necrosis factor (TNF)-α and interleukin (IL)-6 were measured at baseline and after 6 months of treatment, and the data expressed as mean±SD (pg·ml–1·10–6 PBMCs). The LVEF in the statin group improved, and the monocyte TNF-α and IL-6 production decreased (respectively, P<0.001), but the LVEF and cytokine production remained unchanged in the no statin group. Multivariate Cox hazard analysis showed that statin therapy (hazard ratio, 0.14; 95% confidence interval: 0.02–0.97, P=0.046) was an independent predictor of cardiac events. Conclusions: Statin therapy attenuates the production of monocyte pro-inflammatory cytokines, and ameliorates the cardiac function and may improve long-term prognosis in CHF patients with dyslipidemia. (Circ J 2012; 76: 2130–2138)</description><subject>Aged</subject><subject>Chronic Disease</subject><subject>Cytokine</subject><subject>Dyslipidemia</subject><subject>Dyslipidemias - blood</subject><subject>Dyslipidemias - complications</subject><subject>Dyslipidemias - diagnosis</subject><subject>Dyslipidemias - drug therapy</subject><subject>Dyslipidemias - pathology</subject><subject>Dyslipidemias - physiopathology</subject><subject>Female</subject><subject>Heart failure</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - complications</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - drug therapy</subject><subject>Heart Failure - pathology</subject><subject>Heart Failure - physiopathology</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage</subject><subject>Inflammation Mediators - blood</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monocytes - metabolism</subject><subject>Monocytes - pathology</subject><subject>Prognosis</subject><subject>Statin</subject><subject>Stroke Volume</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1u1DAUhSMEoqWwZ4W8ZNEUO3ESe4lCh7YaBBKDWFqOcz3xkNhT21nksXhDPD-0kmVfW985vrony94TfEOKqvykjFe7m_YhJyStonyRXZKSNjllBX55rOucM1peZG9C2GFccFzx19lFUTSswri-zP7eag0qBuQ0-hllNBZtBvByvyBnURwA_fCun1U06ZqYb846tcTjc35v9SinSUbnF9Qu0f0xFsI1aqXvjVRoNduj8BpJ26O1s9t8A346aLfWBRNQ-q4dvLNGoTuQPqKVNOPsk31qBWzq67eJA_qyhNHsTQ-TkW-zV1qOAd6dz6vs1-p2097l6-9f79vP61xVlMScNQ0lklZKdrwGXHesZ7pkaUgV4WUheckZLhgwXumOUcaU5lpJ0nWU9ljx8ir7ePLde_c4Q4hiMkHBOEoLbg6C4OTAWE2bhOITqrwLwYMWe28m6ZcEiUNQ4hiUaB8EIeIQVJJ8OLvP3QT9k-B_MglYnYBdiHILT0AaklEjnB2bWvDD9uz8DAzSC7DlPy_Xq4A</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Nakagomi, Akihiro</creator><creator>Seino, Yoshihiko</creator><creator>Kohashi, Keiichi</creator><creator>Kosugi, Munenori</creator><creator>Endoh, Yasumi</creator><creator>Kusama, Yoshiki</creator><creator>Atarashi, Hirotsugu</creator><creator>Mizuno, Kyoichi</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>Effects of Statin Therapy on the Production of Monocyte Pro-Inflammatory Cytokines, Cardiac Function, and Long-Term Prognosis in Chronic Heart Failure Patients With Dyslipidemia</title><author>Nakagomi, Akihiro ; Seino, Yoshihiko ; Kohashi, Keiichi ; Kosugi, Munenori ; Endoh, Yasumi ; Kusama, Yoshiki ; Atarashi, Hirotsugu ; Mizuno, Kyoichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-87741a45cab96e06b8d8f3812351932a9398028e895fb8488cf9fca1bb44d0c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Chronic Disease</topic><topic>Cytokine</topic><topic>Dyslipidemia</topic><topic>Dyslipidemias - blood</topic><topic>Dyslipidemias - complications</topic><topic>Dyslipidemias - diagnosis</topic><topic>Dyslipidemias - drug therapy</topic><topic>Dyslipidemias - pathology</topic><topic>Dyslipidemias - physiopathology</topic><topic>Female</topic><topic>Heart failure</topic><topic>Heart Failure - blood</topic><topic>Heart Failure - complications</topic><topic>Heart Failure - diagnosis</topic><topic>Heart Failure - drug therapy</topic><topic>Heart Failure - pathology</topic><topic>Heart Failure - physiopathology</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage</topic><topic>Inflammation Mediators - blood</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Monocytes - metabolism</topic><topic>Monocytes - pathology</topic><topic>Prognosis</topic><topic>Statin</topic><topic>Stroke Volume</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakagomi, Akihiro</creatorcontrib><creatorcontrib>Seino, Yoshihiko</creatorcontrib><creatorcontrib>Kohashi, Keiichi</creatorcontrib><creatorcontrib>Kosugi, Munenori</creatorcontrib><creatorcontrib>Endoh, Yasumi</creatorcontrib><creatorcontrib>Kusama, Yoshiki</creatorcontrib><creatorcontrib>Atarashi, Hirotsugu</creatorcontrib><creatorcontrib>Mizuno, Kyoichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakagomi, Akihiro</au><au>Seino, Yoshihiko</au><au>Kohashi, Keiichi</au><au>Kosugi, Munenori</au><au>Endoh, Yasumi</au><au>Kusama, Yoshiki</au><au>Atarashi, Hirotsugu</au><au>Mizuno, Kyoichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Statin Therapy on the Production of Monocyte Pro-Inflammatory Cytokines, Cardiac Function, and Long-Term Prognosis in Chronic Heart Failure Patients With Dyslipidemia</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2012</date><risdate>2012</risdate><volume>76</volume><issue>9</issue><spage>2130</spage><epage>2138</epage><pages>2130-2138</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background: The effects of statin therapy on the production of monocyte pro-inflammatory cytokines, cardiac function and the long-term prognosis in chronic heart failure (CHF) patients with dyslipidemia remain unclear. Methods and Results: A total of 146 CHF patients with a mean left ventricular ejection fraction (LVEF) of 26.9±6.6% were divided into 2 groups based on whether or not statins were included in their treatment: a statin group (n=63) and a no statin group (n=83). Only patients with dyslipidemia were treated with statins. Peripheral blood mononuclear cells (PBMCs) were isolated, and the production of monocyte tumor necrosis factor (TNF)-α and interleukin (IL)-6 were measured at baseline and after 6 months of treatment, and the data expressed as mean±SD (pg·ml–1·10–6 PBMCs). The LVEF in the statin group improved, and the monocyte TNF-α and IL-6 production decreased (respectively, P<0.001), but the LVEF and cytokine production remained unchanged in the no statin group. Multivariate Cox hazard analysis showed that statin therapy (hazard ratio, 0.14; 95% confidence interval: 0.02–0.97, P=0.046) was an independent predictor of cardiac events. Conclusions: Statin therapy attenuates the production of monocyte pro-inflammatory cytokines, and ameliorates the cardiac function and may improve long-term prognosis in CHF patients with dyslipidemia. (Circ J 2012; 76: 2130–2138)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>22785006</pmid><doi>10.1253/circj.CJ-11-1123</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Chronic Disease Cytokine Dyslipidemia Dyslipidemias - blood Dyslipidemias - complications Dyslipidemias - diagnosis Dyslipidemias - drug therapy Dyslipidemias - pathology Dyslipidemias - physiopathology Female Heart failure Heart Failure - blood Heart Failure - complications Heart Failure - diagnosis Heart Failure - drug therapy Heart Failure - pathology Heart Failure - physiopathology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Inflammation Mediators - blood Interleukin-6 - blood Male Middle Aged Monocytes - metabolism Monocytes - pathology Prognosis Statin Stroke Volume Tumor Necrosis Factor-alpha - blood |
| title | Effects of Statin Therapy on the Production of Monocyte Pro-Inflammatory Cytokines, Cardiac Function, and Long-Term Prognosis in Chronic Heart Failure Patients With Dyslipidemia |
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