Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Activates the WNK-OSR1/SPAK-NCC Phosphorylation Cascade in Hyperinsulinemic db/db Mice

Metabolic syndrome patients have insulin resistance, which causes hyperinsulinemia, which in turn causes aberrant increased renal sodium reabsorption. The precise mechanisms underlying this greater salt sensitivity of hyperinsulinemic patients remain unclear. Abnormal activation of the recently iden...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2012-10, Vol.60 (4), p.981-990
Hauptverfasser:	Nishida, Hidenori, Sohara, Eisei, Nomura, Naohiro, Chiga, Motoko, Alessi, Dario R, Rai, Tatemitsu, Sasaki, Sei, Uchida, Shinichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - physiology Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Hyperinsulinism - metabolism Kidney - drug effects Kidney - metabolism Kidney - physiopathology Medical sciences Mice Minor Histocompatibility Antigens Phosphatidylinositol 3-Kinases - metabolism Phosphorylation - drug effects Phosphorylation - physiology Protein Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Receptors, Drug - metabolism Signal Transduction - drug effects Signal Transduction - physiology Sodium Chloride Symporter Inhibitors - pharmacology Solute Carrier Family 12, Member 3 Symporters - metabolism WNK Lysine-Deficient Protein Kinase 1
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