Ageing as a Risk Factor for Disease

Age is the main risk factor for the prevalent diseases of developed countries: cancer, cardiovascular disease and neurodegeneration. The ageing process is deleterious for fitness, but can nonetheless evolve as a consequence of the declining force of natural selection at later ages, attributable to e...

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Veröffentlicht in:	Current biology 2012-09, Vol.22 (17), p.R741-R752
Hauptverfasser:	Niccoli, Teresa, Partridge, Linda
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse effects Aging Autophagy cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - pathology developed countries DNA Damage genome Humans invertebrates Life Expectancy longevity mice Mitochondria - physiology mutation natural selection Neoplasms - epidemiology Neoplasms - pathology Neurodegenerative Diseases - epidemiology Neurodegenerative Diseases - pathology Risk Factors Signal Transduction Time Factors yeasts
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