Peripheral blood gene expression profile of atherosclerotic coronary artery disease in patients of different ethnicity in Malaysia
Abstract The molecular basis of coronary artery disease (CAD) has been widely studied in the western world but there is no published work on the Malaysian population. This study looked at the global gene expression profiling of the peripheral blood of patients with CAD from the 3 main ethnic groups...
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| Veröffentlicht in: | Journal of cardiology 2012-09, Vol.60 (3), p.192-203 |
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| creator | Abdullah, Mohd Hafiz Ngoo, MD Othman, Zulhabri, PhD Noor, Hamdan Mohd, PhD Arshad, Siti Suri, PhD Yusof, Ahmad Khairuddin Mohd, MD Jamal, Rahman, MD, PhD Rahman, Abdul Rashid Abdul, PhD |
| description | Abstract The molecular basis of coronary artery disease (CAD) has been widely studied in the western world but there is no published work on the Malaysian population. This study looked at the global gene expression profiling of the peripheral blood of patients with CAD from the 3 main ethnic groups in Malaysia. Male subjects selected were based on angiographically confirmed CAD (≥50% stenosis) and normal control subjects (0% stenosis) with age range of 55.6 ± 5.3 and 51.0 ± 5.5 years, respectively. The global gene expression of 12 angiographically documented CAD patients and 11 matched control subjects were performed. The combined group samples identified 6 up regulated differential expression (DE) genes ( GHRL , LTA , CBS , HP , ITGA2B , and OLR1 ) and 12 down regulated DE genes ( IL18R1 , ITGA2B , IL18RAP , HP , OLR1 , SOD2 ITGB3 , IL1B , MMP9 , PLA2G7 , UTS2 , and CBS ) to be involved in CAD at the fold change of 1.3 with fault discovery rate (FDR) of 1%. Three genes, MMP9 , IL1B , and SOD2 were down regulated in all the 3 ethnic groups making them potential biomarker candidates for CAD across all three ethnicities. Further verification in a cohort study is needed. |
| doi_str_mv | 10.1016/j.jjcc.2012.05.009 |
| format | Article |
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This study looked at the global gene expression profiling of the peripheral blood of patients with CAD from the 3 main ethnic groups in Malaysia. Male subjects selected were based on angiographically confirmed CAD (≥50% stenosis) and normal control subjects (0% stenosis) with age range of 55.6 ± 5.3 and 51.0 ± 5.5 years, respectively. The global gene expression of 12 angiographically documented CAD patients and 11 matched control subjects were performed. The combined group samples identified 6 up regulated differential expression (DE) genes ( GHRL , LTA , CBS , HP , ITGA2B , and OLR1 ) and 12 down regulated DE genes ( IL18R1 , ITGA2B , IL18RAP , HP , OLR1 , SOD2 ITGB3 , IL1B , MMP9 , PLA2G7 , UTS2 , and CBS ) to be involved in CAD at the fold change of 1.3 with fault discovery rate (FDR) of 1%. Three genes, MMP9 , IL1B , and SOD2 were down regulated in all the 3 ethnic groups making them potential biomarker candidates for CAD across all three ethnicities. Further verification in a cohort study is needed.</description><identifier>ISSN: 0914-5087</identifier><identifier>EISSN: 1876-4738</identifier><identifier>DOI: 10.1016/j.jjcc.2012.05.009</identifier><identifier>PMID: 22738689</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Biomarkers - blood ; Cardiovascular ; Coronary artery disease ; Coronary Artery Disease - blood ; Coronary Artery Disease - genetics ; Down-Regulation ; Ethnic Groups ; Gene Expression ; Humans ; IL1B ; Malaysia ; Male ; Microarray Analysis ; Middle Aged ; MMP9 ; SOD2 ; Software ; Up-Regulation</subject><ispartof>Journal of cardiology, 2012-09, Vol.60 (3), p.192-203</ispartof><rights>Japanese College of Cardiology</rights><rights>2012 Japanese College of Cardiology</rights><rights>Copyright © 2012 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-bfa1d787a42116a20ae2b1fd8fb83fa763deb4789c9e683903e27e51d354c7773</citedby><cites>FETCH-LOGICAL-c479t-bfa1d787a42116a20ae2b1fd8fb83fa763deb4789c9e683903e27e51d354c7773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jjcc.2012.05.009$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22738689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdullah, Mohd Hafiz Ngoo, MD</creatorcontrib><creatorcontrib>Othman, Zulhabri, PhD</creatorcontrib><creatorcontrib>Noor, Hamdan Mohd, PhD</creatorcontrib><creatorcontrib>Arshad, Siti Suri, PhD</creatorcontrib><creatorcontrib>Yusof, Ahmad Khairuddin Mohd, MD</creatorcontrib><creatorcontrib>Jamal, Rahman, MD, PhD</creatorcontrib><creatorcontrib>Rahman, Abdul Rashid Abdul, PhD</creatorcontrib><title>Peripheral blood gene expression profile of atherosclerotic coronary artery disease in patients of different ethnicity in Malaysia</title><title>Journal of cardiology</title><addtitle>J Cardiol</addtitle><description>Abstract The molecular basis of coronary artery disease (CAD) has been widely studied in the western world but there is no published work on the Malaysian population. This study looked at the global gene expression profiling of the peripheral blood of patients with CAD from the 3 main ethnic groups in Malaysia. Male subjects selected were based on angiographically confirmed CAD (≥50% stenosis) and normal control subjects (0% stenosis) with age range of 55.6 ± 5.3 and 51.0 ± 5.5 years, respectively. The global gene expression of 12 angiographically documented CAD patients and 11 matched control subjects were performed. The combined group samples identified 6 up regulated differential expression (DE) genes ( GHRL , LTA , CBS , HP , ITGA2B , and OLR1 ) and 12 down regulated DE genes ( IL18R1 , ITGA2B , IL18RAP , HP , OLR1 , SOD2 ITGB3 , IL1B , MMP9 , PLA2G7 , UTS2 , and CBS ) to be involved in CAD at the fold change of 1.3 with fault discovery rate (FDR) of 1%. Three genes, MMP9 , IL1B , and SOD2 were down regulated in all the 3 ethnic groups making them potential biomarker candidates for CAD across all three ethnicities. Further verification in a cohort study is needed.</description><subject>Biomarkers - blood</subject><subject>Cardiovascular</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - genetics</subject><subject>Down-Regulation</subject><subject>Ethnic Groups</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>IL1B</subject><subject>Malaysia</subject><subject>Male</subject><subject>Microarray Analysis</subject><subject>Middle Aged</subject><subject>MMP9</subject><subject>SOD2</subject><subject>Software</subject><subject>Up-Regulation</subject><issn>0914-5087</issn><issn>1876-4738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEURoMoTk_rC7iQLN1UmZ_qSgpEkEFHYURBXYdU6sZJma60SVrsrU_uLXp04cIsEgLnu_CdS8gTzlrOeP98bufZuVYwLlq2axkb7pEN16pvOiX1fbJhA--aHdPqglyWMjPWs0H3D8mFEAj0etiQXx8hh8MtZBvpGFOa6FdYgMLPQ4ZSQlroIScfItDkqa0IpuIi3jU46lJOi80nanMFfKZQwBagAVO2BlhqWWNT8B4y_ijU2yW4UE8r8t5GeyrBPiIPvI0FHt-9W_LlzevPV2-bmw_X765e3TSuU0NtRm_5pLSyneC8t4JZECP3k_ajlt6qXk4wdkoPboBey4FJEAp2fJK7ziml5JY8O8_FRt-PUKrZh-IgRrtAOhbDmRy07iSeLRFn1GHdksGbQw57bIqQWd2b2azuzeresJ1B9xh6ejf_OO5h-hv5IxuBF2cAsOWPANkUh5IcTCGDq2ZK4f_zX_4TdzGgThu_wQnKnI55QX-Gm4IZ82nd_rp8LhjDbkr-Bk1brT8</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Abdullah, Mohd Hafiz Ngoo, MD</creator><creator>Othman, Zulhabri, PhD</creator><creator>Noor, Hamdan Mohd, PhD</creator><creator>Arshad, Siti Suri, PhD</creator><creator>Yusof, Ahmad Khairuddin Mohd, MD</creator><creator>Jamal, Rahman, MD, PhD</creator><creator>Rahman, Abdul Rashid Abdul, PhD</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120901</creationdate><title>Peripheral blood gene expression profile of atherosclerotic coronary artery disease in patients of different ethnicity in Malaysia</title><author>Abdullah, Mohd Hafiz Ngoo, MD ; Othman, Zulhabri, PhD ; Noor, Hamdan Mohd, PhD ; Arshad, Siti Suri, PhD ; Yusof, Ahmad Khairuddin Mohd, MD ; Jamal, Rahman, MD, PhD ; Rahman, Abdul Rashid Abdul, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-bfa1d787a42116a20ae2b1fd8fb83fa763deb4789c9e683903e27e51d354c7773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biomarkers - blood</topic><topic>Cardiovascular</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - genetics</topic><topic>Down-Regulation</topic><topic>Ethnic Groups</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>IL1B</topic><topic>Malaysia</topic><topic>Male</topic><topic>Microarray Analysis</topic><topic>Middle Aged</topic><topic>MMP9</topic><topic>SOD2</topic><topic>Software</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdullah, Mohd Hafiz Ngoo, MD</creatorcontrib><creatorcontrib>Othman, Zulhabri, PhD</creatorcontrib><creatorcontrib>Noor, Hamdan Mohd, PhD</creatorcontrib><creatorcontrib>Arshad, Siti Suri, PhD</creatorcontrib><creatorcontrib>Yusof, Ahmad Khairuddin Mohd, MD</creatorcontrib><creatorcontrib>Jamal, Rahman, MD, PhD</creatorcontrib><creatorcontrib>Rahman, Abdul Rashid Abdul, PhD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdullah, Mohd Hafiz Ngoo, MD</au><au>Othman, Zulhabri, PhD</au><au>Noor, Hamdan Mohd, PhD</au><au>Arshad, Siti Suri, PhD</au><au>Yusof, Ahmad Khairuddin Mohd, MD</au><au>Jamal, Rahman, MD, PhD</au><au>Rahman, Abdul Rashid Abdul, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral blood gene expression profile of atherosclerotic coronary artery disease in patients of different ethnicity in Malaysia</atitle><jtitle>Journal of cardiology</jtitle><addtitle>J Cardiol</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>60</volume><issue>3</issue><spage>192</spage><epage>203</epage><pages>192-203</pages><issn>0914-5087</issn><eissn>1876-4738</eissn><abstract>Abstract The molecular basis of coronary artery disease (CAD) has been widely studied in the western world but there is no published work on the Malaysian population. This study looked at the global gene expression profiling of the peripheral blood of patients with CAD from the 3 main ethnic groups in Malaysia. Male subjects selected were based on angiographically confirmed CAD (≥50% stenosis) and normal control subjects (0% stenosis) with age range of 55.6 ± 5.3 and 51.0 ± 5.5 years, respectively. The global gene expression of 12 angiographically documented CAD patients and 11 matched control subjects were performed. The combined group samples identified 6 up regulated differential expression (DE) genes ( GHRL , LTA , CBS , HP , ITGA2B , and OLR1 ) and 12 down regulated DE genes ( IL18R1 , ITGA2B , IL18RAP , HP , OLR1 , SOD2 ITGB3 , IL1B , MMP9 , PLA2G7 , UTS2 , and CBS ) to be involved in CAD at the fold change of 1.3 with fault discovery rate (FDR) of 1%. Three genes, MMP9 , IL1B , and SOD2 were down regulated in all the 3 ethnic groups making them potential biomarker candidates for CAD across all three ethnicities. Further verification in a cohort study is needed.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>22738689</pmid><doi>10.1016/j.jjcc.2012.05.009</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers - blood Cardiovascular Coronary artery disease Coronary Artery Disease - blood Coronary Artery Disease - genetics Down-Regulation Ethnic Groups Gene Expression Humans IL1B Malaysia Male Microarray Analysis Middle Aged MMP9 SOD2 Software Up-Regulation |
| title | Peripheral blood gene expression profile of atherosclerotic coronary artery disease in patients of different ethnicity in Malaysia |
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