Involvement of NF-κB transcription factors in antimicrobial peptide gene induction in the red flour beetle, Tribolium castaneum

► IMD-dependent antimicrobial peptide genes were revealed to be Rel-dependent. ► Toll-dependent antimicrobial peptide genes were shown to be Dif-dependent. ► Rel knockdown impaired host defense against two model bacterial pathogens. We previously demonstrated that Tribolium castaneum antimicrobical...

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Veröffentlicht in:	Developmental and comparative immunology 2012-10, Vol.38 (2), p.342-351
Hauptverfasser:	Yokoi, Kakeru, Koyama, Hiroaki, Ito, Wataru, Minakuchi, Chieka, Tanaka, Toshiharu, Miura, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine monophosphate Animals Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - immunology Antimicrobial peptide antimicrobial peptides Drosophila Drosophila melanogaster - metabolism Escherichia coli Gene Expression Regulation gene induction Gene Knockdown Techniques genes immune response Immunity, Innate Innate immunity Micrococcus luteus NF-kappa B - metabolism NF-κB pathogens Saccharomyces cerevisiae transcription factor NF-kappa B Tribolium - immunology Tribolium - metabolism Tribolium castaneum
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