Synthesis and Biological Investigations of Nitric Oxide Releasing Nateglinide and Meglitinide Type II Antidiabetic Prodrugs: In-Vivo Antihyperglycemic Activities and Blood Pressure Lowering Studies

A new group of hybrid nitric oxide-releasing type II antidiabetic drugs possessing a 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (13 and 18), 1-(N,N-diethylamino)diazen-1-ium-1,2-diolate (14 and 19), or nitrooxyethyl (15 and 20) moiety attached to the carboxylic acid group of the type II antidiabeti...

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Veröffentlicht in:	Journal of medicinal chemistry 2012-09, Vol.55 (17), p.7883-7891
Hauptverfasser:	Kaur, Jatinder, Bhardwaj, Atul, Huang, Zhangjian, Narang, Deepak, Chen, Ting-Yueh, Plane, Frances, Knaus, Edward E
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzamides - pharmacology Benzamides - therapeutic use Blood Pressure - drug effects Cyclohexanes - pharmacology Cyclohexanes - therapeutic use Humans Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Magnetic Resonance Spectroscopy Nitric Oxide - metabolism Phenylalanine - analogs & derivatives Phenylalanine - pharmacology Phenylalanine - therapeutic use Prodrugs - therapeutic use Spectrometry, Mass, Electrospray Ionization
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