Intestinal Ellagitannin Metabolites Ameliorate Cytokine-Induced Inflammation and Associated Molecular Markers in Human Colon Fibroblasts

Pomegranate ellagitannins (ETs) are transformed in the gut to ellagic acid (EA) and its microbiota metabolites, urolithin A (Uro-A) and urolithin B (Uro-B). These compounds exert anti-inflammatory effects in vitro and in vivo. The aim of this study was to investigate the effects of Uro-A, Uro-B, and...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2012-09, Vol.60 (36), p.8866-8876
Hauptverfasser:	Giménez-Bastida, Juan A, Larrosa, Mar, González-Sarrías, Antonio, Tomás-Barberán, Francisco, Espín, Juan C, García-Conesa, María-Teresa
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion anti-inflammatory activity Anti-Inflammatory Agents - immunology Anti-Inflammatory Agents - metabolism Biological and medical sciences Biomarkers - metabolism Biotransformation Cell Line Cell Movement colon Colon - immunology Coumarins - immunology Coumarins - metabolism ellagic acid Ellagic Acid - immunology Ellagic Acid - metabolism fibroblasts Fibroblasts - cytology Fibroblasts - immunology Food industries Fundamental and applied biological sciences. Psychology genetic markers growth factors Humans Hydrolyzable Tannins - metabolism inflammation Inflammation - drug therapy Inflammation - genetics Inflammation - immunology interleukin-1 Interleukin-1beta - immunology interleukin-8 Interleukin-8 - genetics Interleukin-8 - metabolism Intestines - immunology Intestines - metabolism metabolites Plant Extracts - metabolism Plasminogen Activator Inhibitor 1 - genetics Plasminogen Activator Inhibitor 1 - metabolism pomegranates Punicaceae - chemistry tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - immunology
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