Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma

The molecular pathogenesis of natural killer/T-cell lymphoma (NKTCL) is not well understood. We conducted whole-exome sequencing and identified Janus kinase 3 (JAK3) somatic-activating mutations (A572V and A573V) in 2 of 4 patients with NKTCLs. Further validation of the prevalence of JAK3 mutations...

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Veröffentlicht in:	Cancer discovery 2012-07, Vol.2 (7), p.591-597
Hauptverfasser:	Koo, Ghee Chong, Tan, Soo Yong, Tang, Tiffany, Poon, Song Ling, Allen, George E, Tan, Leonard, Chong, Soo Ching, Ong, Whee Sze, Tay, Kevin, Tao, Miriam, Quek, Richard, Loong, Susan, Yeoh, Kheng-Wei, Yap, Swee Peng, Lee, Kuo Ann, Lim, Lay Cheng, Tan, Daryl, Goh, Christopher, Cutcutache, Ioana, Yu, Willie, Ng, Cedric Chuan Young, Rajasegaran, Vikneswari, Heng, Hong Lee, Gan, Anna, Ong, Choon Kiat, Rozen, Steve, Tan, Patrick, Teh, Bin Tean, Lim, Soon Thye
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals Blotting, Western Cell Line, Tumor Cell Proliferation DNA Mutational Analysis Enzyme Activation - genetics Female Humans Janus Kinase 3 - antagonists & inhibitors Janus Kinase 3 - genetics Janus Kinase 3 - metabolism Lymphoma, T-Cell - genetics Lymphoma, T-Cell - metabolism Lymphoma, T-Cell - pathology Male Middle Aged Mutation Natural Killer T-Cells - metabolism Natural Killer T-Cells - pathology Phosphorylation Piperidines Pyrimidines - pharmacology Pyrroles - pharmacology RNA Interference STAT5 Transcription Factor - metabolism
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