Full factorial design, physicochemical characterisation and biological assessment of cyclosporine A loaded cationic nanoparticles

PLGA NPs coated with 0.3%(w/V) chitosan solution retained a positive zeta potential after dispersion in SLF which supports the possibility of an interaction between these NPs and the negatively charged mucus layer at the eye. In addition, significant suppression of IL-2 secretion by all NPs in ConA-...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2012-09, Vol.82 (1), p.27-35
Hauptverfasser:	Hermans, Kris, Van den Plas, Dave, Everaert, Arnout, Weyenberg, Wim, Ludwig, Annick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cations Chitosan Chitosan - chemistry Cyclosporine - administration & dosage Cyclosporine - pharmacology Cyclosporine A Drug Carriers - chemistry Drug Compounding Emulsions Epithelial Cells - metabolism Factorial design General pharmacology Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacology Jurkat Cells Lactic Acid - chemistry Medical sciences Mucus - metabolism Nanoparticles Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments PLGA Polyglycolic Acid - chemistry Solvents - chemistry Static Electricity Swine Tears - metabolism
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