Predictive combinations of monitor alarms preceding in-hospital code blue events

[Display omitted] ► A novel concept – SuperAlarm proposed as a technique to alleviate alarm fatigue. ► SuperAlarm is a set of predictive combinations of monitor alarms. ► An alarm-mining algorithm proposed to find SuperAlarm set predictive of code blue. ► Repetition rate of alarms in a given time period is considered in the algorithm. ► Cross-validation and test is done on alarm data from 223 code blue and 1768 control patients. Bedside monitors are ubiquitous in acute care units of modern healthcare enterprises. However, they have been criticized for generating an excessive number of false positive alarms causing alarm fatigue among care givers and potentially compromising patient safety. We hypothesize that combinations of regular monitor alarms denoted as SuperAlarm set may be more indicative of ongoing patient deteriorations and hence predictive of in-hospital code blue events. The present work develops and assesses an alarm mining approach based on finding frequent combinations of single alarms that are also specific to code blue events to compose a SuperAlarm set. We use 4-way analysis of variance (ANOVA) to investigate the influence of four algorithm parameters on the performance of the data mining approach. The results are obtained from millions of monitor alarms from a cohort of 223 adult code blue and 1768 control patients using a multiple 10-fold cross-validation experiment setup. Using the optimal setting of parameters determined in the cross-validation experiment, final SuperAlarm sets are mined from the training data and used on an independent test data set to simulate running a SuperAlarm set against live regular monitor alarms. The ANOVA shows that the content of a SuperAlarm set is influenced by a subset of key algorithm parameters. Simulation of the extracted SuperAlarm set shows that it can predict code blue events one hour ahead with sensitivity between 66.7% and 90.9% while producing false SuperAlarms for control patients that account for between 2.2% and 11.2% of regular monitor alarms depending on user-supplied acceptable false positive rate. We conclude that even though the present work is still preliminary due to the usage of a moderately-sized database to test our hypothesis it represents an effort to develop algorithms to alleviate the alarm fatigue issue in a unique way.