Modulation of telomerase and signal transduction proteins by Hexyl-ALA-Photodynamic Therapy (PDT) in human doxorubicin resistant cancer cell models

Summary Aims This study employed a doxorubicin resistant (MES-SA-Dx5) human uterine sarcoma cell line and its counterpart (MES-SA), to elucidate the efficacy of aminolevulinic acid-hexylester (hexyl-ALA) mediated PDT at molecular and transcriptional levels. Methods Hexyl-ALA generated protoporphyrin...

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Veröffentlicht in:	Photodiagnosis and photodynamic therapy 2012-09, Vol.9 (3), p.243-255
Hauptverfasser:	Chu, Ellie S.M, Yow, Christine M.N., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminolevulinic Acid - administration & dosage Aminolevulinic Acid - analogs & derivatives Apoptosis - drug effects Cell Line, Tumor Cell Movement - drug effects Dose-Response Relationship, Drug Doxorubicin - therapeutic use Drug resistance Drug Resistance, Neoplasm - drug effects Female Hematology, Oncology and Palliative Medicine Hexyl-ALA Humans Internal Medicine MAPK Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - administration & dosage Signal Transduction - drug effects Telomerase Telomerase - metabolism Transcription Factors - metabolism Uterine Neoplasms - drug therapy Uterine Neoplasms - metabolism Uterine Neoplasms - pathology Uterine sarcoma
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