New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms

New oxirane derivatives were synthesized using six naphthoquinones as the starting material. Our biological results showed that these oxiranes acted as trypanocidal agents against Trypanosoma cruzi with minimal cytotoxicity in the VERO cell line compared to naphthoquinones. In particular, oxirane de...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2012-08, Vol.20 (16), p.4995-5000
Hauptverfasser:	Carneiro, Paula F., do Nascimento, Samara B., Pinto, Antonio V., Pinto, Maria do Carmo F.R., Lechuga, Guilherme C., Santos, Dilvani O., dos Santos Júnior, Helvécio M., Resende, Jackson A.L.C., Bourguignon, Saulo C., Ferreira, Vitor F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Death - drug effects Cell Survival - drug effects Cercopithecus aethiops Chagas disease chemistry cytotoxicity Dose-Response Relationship, Drug Drug Evaluation, Preclinical drugs ethylene oxide Ethylene Oxide - analogs & derivatives Ethylene Oxide - chemistry Ethylene Oxide - pharmacology mammals Medical sciences Models, Molecular Molecular Structure Naphthoquinone naphthoquinones Naphthoquinones - chemistry Naphthoquinones - pharmacology Oxiranes Parasitic Sensitivity Tests Pharmacology. Drug treatments Structure-Activity Relationship Trypanocidal Agents - chemical synthesis Trypanocidal Agents - chemistry Trypanocidal Agents - pharmacology Trypanosoma cruzi Trypanosoma cruzi - cytology Trypanosoma cruzi - drug effects Trypanosoma cruzi - growth & development Vero Cells
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