Inhibition of ROS-induced p38MAPK and ERK activation in microglia by acupuncture relieves neuropathic pain after spinal cord injury in rats

Acupuncture (AP) is currently used worldwide to relieve pain. However, little is known about its mechanisms of action. We found that after spinal cord injury (SCI), AP inhibited the production of superoxide anion (O2), which acted as a modulator for microglial activation, and the analgesic effect of...

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Veröffentlicht in:	Experimental neurology 2012-08, Vol.236 (2), p.268-282
Hauptverfasser:	Choi, Doo C., Lee, Jee Y., Lim, Eun J., Baik, Hyung H., Oh, Tae H., Yune, Tae Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acupuncture Acupuncture Therapy - methods Analgesics Animals Biological and medical sciences Central neuropathic pain Chronic Disease Disease Models, Animal Enzyme Activation - physiology Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - metabolism Inflammation Injuries of the nervous system and the skull. Diseases due to physical agents Male MAPK kinase Medical sciences Microglia Microglia - enzymology Microglia - pathology Neuralgia - enzymology Neuralgia - etiology Neuralgia - therapy Neurology Neuromodulation Neuropathy p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Pain Measurement - methods Pain perception Prostaglandin E2 Rats Rats, Sprague-Dawley Reactive oxygen species Reactive Oxygen Species - administration & dosage Reactive Oxygen Species - antagonists & inhibitors Spinal Cord Injuries - complications Spinal Cord Injuries - enzymology Spinal Cord Injuries - therapy Spinal cord injury superoxide anions Traumas. Diseases due to physical agents
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