Human mitochondrial RNA polymerase: Structure–function, mechanism and inhibition

Transcription of the human mitochondrial genome is required for the expression of 13 subunits of the respiratory chain complexes involved in oxidative phosphorylation, which is responsible for meeting the cells' energy demands in the form of ATP. Also transcribed are the two rRNAs and 22 tRNAs...

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Veröffentlicht in:	Biochimica et biophysica acta 2012-09, Vol.1819 (9-10), p.948-960
Hauptverfasser:	Arnold, Jamie J., Smidansky, Eric D., Moustafa, Ibrahim M., Cameron, Craig E.
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP Crystal structure DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism DNA-directed RNA polymerase DNA-Directed RNA Polymerases - genetics DNA-Directed RNA Polymerases - metabolism Electron transport Enzymes Gene expression Gene Expression Regulation Genomes Humans Ionizing radiation Kinetics Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondrial DNA Mitochondrial RNA polymerase Mitochondrion Molecular modelling mtRNAP Nucleotides Oxidative phosphorylation Phages POLRMT primase Promoters Protein Biosynthesis Protein Conformation Replication RNA, Ribosomal - chemistry RNA, Ribosomal - genetics rRNA Structure-Activity Relationship Structure-function relationships Transcription Transcription initiation Transcription, Genetic Translation tRNA
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