Carbapenem-resistant Enterobacteriaceae containing New Delhi metallo-beta-lactamase in two patients - Rhode Island, March 2012
U.S. and international efforts to control carabapenem-resistant Enterobacteriaceae (CRE) are critical to protect public health. Clinicians caring for patients infected with such organisms have few, if any, therapeutic options available. CRE containing New Delhi metallo-beta-lactamase (NDM), first re...
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Veröffentlicht in: | MMWR. Morbidity and mortality weekly report 2012-06, Vol.61 (24), p.446-448 |
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creator | Hardy, Erica E Mermel, Leonard A Chapin, Kimberle C Alpert, Warren Vanner, Cindy Gupta, Ekta |
description | U.S. and international efforts to control carabapenem-resistant Enterobacteriaceae (CRE) are critical to protect public health. Clinicians caring for patients infected with such organisms have few, if any, therapeutic options available. CRE containing New Delhi metallo-beta-lactamase (NDM), first reported in a patient who had been hospitalized in New Delhi, India, in 2007, are of particular concern because these enzymes usually are encoded on plasmids that harbor multiple resistance determinants and are transmitted easily to other Enterobacteriaceae and other genera of bacteria. A urine specimen collected on March 4, 2012, from a patient who recently had been hospitalized in Viet Nam, but who was receiving care at a hospital in Rhode Island, was found to have a Klebsiella pneumoniae isolate containing NDM. The isolate was susceptible only to tigecycline, colistin, and polymyxin B. Point-prevalence surveys of epidemiologically linked patients revealed transmission to a second patient on the hematology/oncology unit. These two cases bring to 13 the number of cases of NDM reported in the United States. After contact precautions were reinforced and environmental cleaning was implemented, no further cases were identified. Similarly aggressive infection control efforts can limit the spread of NDM in acute-care medical facilities. |
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Clinicians caring for patients infected with such organisms have few, if any, therapeutic options available. CRE containing New Delhi metallo-beta-lactamase (NDM), first reported in a patient who had been hospitalized in New Delhi, India, in 2007, are of particular concern because these enzymes usually are encoded on plasmids that harbor multiple resistance determinants and are transmitted easily to other Enterobacteriaceae and other genera of bacteria. A urine specimen collected on March 4, 2012, from a patient who recently had been hospitalized in Viet Nam, but who was receiving care at a hospital in Rhode Island, was found to have a Klebsiella pneumoniae isolate containing NDM. The isolate was susceptible only to tigecycline, colistin, and polymyxin B. Point-prevalence surveys of epidemiologically linked patients revealed transmission to a second patient on the hematology/oncology unit. These two cases bring to 13 the number of cases of NDM reported in the United States. After contact precautions were reinforced and environmental cleaning was implemented, no further cases were identified. Similarly aggressive infection control efforts can limit the spread of NDM in acute-care medical facilities.</description><identifier>ISSN: 0149-2195</identifier><identifier>EISSN: 1545-861X</identifier><identifier>PMID: 22717513</identifier><language>eng</language><publisher>United States: U.S. Government Printing Office</publisher><subject>Antibiotics ; Bacteria ; Beta lactamases ; beta-Lactamases - genetics ; Cambodia ; Carbapenems - pharmacology ; Care and treatment ; Contamination ; Cross Infection ; Drug resistance in microorganisms ; Drug Resistance, Multiple ; Enterobacteriaceae ; Enzymes ; Female ; Hand ; Health aspects ; Humans ; Hygiene ; Infection Control ; Klebsiella Infections - drug therapy ; Klebsiella pneumoniae - enzymology ; Klebsiella pneumoniae - isolation & purification ; Morbidity ; Mortality ; Plasmids ; Public health ; Rhode Island ; Travel</subject><ispartof>MMWR. 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Morbidity and mortality weekly report</title><addtitle>MMWR Morb Mortal Wkly Rep</addtitle><description>U.S. and international efforts to control carabapenem-resistant Enterobacteriaceae (CRE) are critical to protect public health. Clinicians caring for patients infected with such organisms have few, if any, therapeutic options available. CRE containing New Delhi metallo-beta-lactamase (NDM), first reported in a patient who had been hospitalized in New Delhi, India, in 2007, are of particular concern because these enzymes usually are encoded on plasmids that harbor multiple resistance determinants and are transmitted easily to other Enterobacteriaceae and other genera of bacteria. A urine specimen collected on March 4, 2012, from a patient who recently had been hospitalized in Viet Nam, but who was receiving care at a hospital in Rhode Island, was found to have a Klebsiella pneumoniae isolate containing NDM. The isolate was susceptible only to tigecycline, colistin, and polymyxin B. Point-prevalence surveys of epidemiologically linked patients revealed transmission to a second patient on the hematology/oncology unit. These two cases bring to 13 the number of cases of NDM reported in the United States. After contact precautions were reinforced and environmental cleaning was implemented, no further cases were identified. Similarly aggressive infection control efforts can limit the spread of NDM in acute-care medical facilities.</description><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Beta lactamases</subject><subject>beta-Lactamases - genetics</subject><subject>Cambodia</subject><subject>Carbapenems - pharmacology</subject><subject>Care and treatment</subject><subject>Contamination</subject><subject>Cross Infection</subject><subject>Drug resistance in microorganisms</subject><subject>Drug Resistance, Multiple</subject><subject>Enterobacteriaceae</subject><subject>Enzymes</subject><subject>Female</subject><subject>Hand</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hygiene</subject><subject>Infection Control</subject><subject>Klebsiella Infections - drug therapy</subject><subject>Klebsiella pneumoniae - enzymology</subject><subject>Klebsiella pneumoniae - isolation & purification</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Plasmids</subject><subject>Public health</subject><subject>Rhode Island</subject><subject>Travel</subject><issn>0149-2195</issn><issn>1545-861X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNklFrFDEQx4NY7Hn6FSQgiA-mbJLN7eaxnFULrYL0wbdlkp29jWSTM8lRfPGzm9IKFu6hMwx_GH4TJn_mGVlx1SrWb_iP52TV8FYzwbU6JS9z_tnchWxekFMhOt4pLlfkzxaSgT0GXFjC7HKBUOhFKJiiAVvFgUVAamMo4IILO_oVb-lH9LOjCxbwPjJTlfmKwwIZqQu03Ea6h-IwlEwZ_T7HEell9hDGD_Qakp2paLh4RU4m8BlfP-ia3Hy6uNl-YVffPl9uz6_YTmhVWLsZJ9PrWpZvpDGj7Kxopg61Eb2xfQuNbtqxb2XtAjdKoWk7LfXEeYe9XJP398_uU_x1wFyGxWWLvq6D8ZAH3shqmdKqewJaDe0rryv69h7dgcfBhSmWBPYOH86F1kpu2rrRmrAj1K46nsDHgJOr7Uf82RG-5oiLs0cH3v03MCP4MufoD8XFkB-Dbx6-djALjsM-uQXS7-HfNci_ySOu2Q</recordid><startdate>20120622</startdate><enddate>20120622</enddate><creator>Hardy, Erica E</creator><creator>Mermel, Leonard A</creator><creator>Chapin, Kimberle C</creator><creator>Alpert, Warren</creator><creator>Vanner, Cindy</creator><creator>Gupta, Ekta</creator><general>U.S. Government Printing Office</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20120622</creationdate><title>Carbapenem-resistant Enterobacteriaceae containing New Delhi metallo-beta-lactamase in two patients - Rhode Island, March 2012</title><author>Hardy, Erica E ; Mermel, Leonard A ; Chapin, Kimberle C ; Alpert, Warren ; Vanner, Cindy ; Gupta, Ekta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g295t-46dfb89fb8c163bbd37c20f7e9b28bc84a0904d84320fa1b55eb47939f117e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Antibiotics</topic><topic>Bacteria</topic><topic>Beta lactamases</topic><topic>beta-Lactamases - genetics</topic><topic>Cambodia</topic><topic>Carbapenems - pharmacology</topic><topic>Care and treatment</topic><topic>Contamination</topic><topic>Cross Infection</topic><topic>Drug resistance in microorganisms</topic><topic>Drug Resistance, Multiple</topic><topic>Enterobacteriaceae</topic><topic>Enzymes</topic><topic>Female</topic><topic>Hand</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hygiene</topic><topic>Infection Control</topic><topic>Klebsiella Infections - drug therapy</topic><topic>Klebsiella pneumoniae - enzymology</topic><topic>Klebsiella pneumoniae - isolation & purification</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Plasmids</topic><topic>Public health</topic><topic>Rhode Island</topic><topic>Travel</topic><toplevel>online_resources</toplevel><creatorcontrib>Hardy, Erica E</creatorcontrib><creatorcontrib>Mermel, Leonard A</creatorcontrib><creatorcontrib>Chapin, Kimberle C</creatorcontrib><creatorcontrib>Alpert, Warren</creatorcontrib><creatorcontrib>Vanner, Cindy</creatorcontrib><creatorcontrib>Gupta, Ekta</creatorcontrib><creatorcontrib>Centers for Disease Control and Prevention (CDC)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>MMWR. 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A urine specimen collected on March 4, 2012, from a patient who recently had been hospitalized in Viet Nam, but who was receiving care at a hospital in Rhode Island, was found to have a Klebsiella pneumoniae isolate containing NDM. The isolate was susceptible only to tigecycline, colistin, and polymyxin B. Point-prevalence surveys of epidemiologically linked patients revealed transmission to a second patient on the hematology/oncology unit. These two cases bring to 13 the number of cases of NDM reported in the United States. After contact precautions were reinforced and environmental cleaning was implemented, no further cases were identified. Similarly aggressive infection control efforts can limit the spread of NDM in acute-care medical facilities.</abstract><cop>United States</cop><pub>U.S. Government Printing Office</pub><pmid>22717513</pmid><tpages>3</tpages></addata></record> |
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subjects | Antibiotics Bacteria Beta lactamases beta-Lactamases - genetics Cambodia Carbapenems - pharmacology Care and treatment Contamination Cross Infection Drug resistance in microorganisms Drug Resistance, Multiple Enterobacteriaceae Enzymes Female Hand Health aspects Humans Hygiene Infection Control Klebsiella Infections - drug therapy Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - isolation & purification Morbidity Mortality Plasmids Public health Rhode Island Travel |
title | Carbapenem-resistant Enterobacteriaceae containing New Delhi metallo-beta-lactamase in two patients - Rhode Island, March 2012 |
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