Sex differences in cardiac autonomic function of depressed young adults
► Heart rate variability of depressed adults under orthostatic stress was examined. ► Depressed males showed reduced HRV and parasympathetic activity. ► Reduced HRV and increased LF/HF in males linked to higher cardiovascular risk. ► The relationship between depression and cardiac dysfunction may be...
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| Veröffentlicht in: | Biological psychology 2012-07, Vol.90 (3), p.179-185 |
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| creator | Garcia, R.G. Zarruk, J.G. Guzman, J.C. Barrera, C. Pinzon, A. Trillos, E. Lopez-Jaramillo, P. Morillo, C.A. Maior, R.S. Diaz-Quijano, F.A. Tomaz, C. |
| description | ► Heart rate variability of depressed adults under orthostatic stress was examined. ► Depressed males showed reduced HRV and parasympathetic activity. ► Reduced HRV and increased LF/HF in males linked to higher cardiovascular risk. ► The relationship between depression and cardiac dysfunction may be sex-dependent.
Cardiac autonomic dysfunction has been proposed as an important contributing factor to the increased cardiovascular risk observed in major depression (MDD). However, the evidence regarding alterations in heart rate variability (HRV) in otherwise healthy depressed subjects has been inconclusive.
A case–control study in 50 treatment-naïve young adults with a first MDD episode without comorbid psychiatric disorders and 50 healthy control subjects was conducted. Time- and frequency-domain indexes of HRV were determined at baseline supine and after 5-min of orthostatic stress at 60°.
There were no significant differences in the time- or frequency-domain variables of HRV between depressed patients and controls. However, a random-effect ANOVA model showed that during orthostatic stress depressed men had a reduced HRV and decreased parasympathetic activity compared to control subjects, while no differences were found between depressed women and controls.
These results suggest a sex-dependent relationship between major depression and cardiac autonomic dysfunction and provide one potential explanation for sex differences in the association of depressive symptoms with cardiovascular morbidity. |
| doi_str_mv | 10.1016/j.biopsycho.2012.03.016 |
| format | Article |
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Cardiac autonomic dysfunction has been proposed as an important contributing factor to the increased cardiovascular risk observed in major depression (MDD). However, the evidence regarding alterations in heart rate variability (HRV) in otherwise healthy depressed subjects has been inconclusive.
A case–control study in 50 treatment-naïve young adults with a first MDD episode without comorbid psychiatric disorders and 50 healthy control subjects was conducted. Time- and frequency-domain indexes of HRV were determined at baseline supine and after 5-min of orthostatic stress at 60°.
There were no significant differences in the time- or frequency-domain variables of HRV between depressed patients and controls. However, a random-effect ANOVA model showed that during orthostatic stress depressed men had a reduced HRV and decreased parasympathetic activity compared to control subjects, while no differences were found between depressed women and controls.
These results suggest a sex-dependent relationship between major depression and cardiac autonomic dysfunction and provide one potential explanation for sex differences in the association of depressive symptoms with cardiovascular morbidity.</description><identifier>ISSN: 0301-0511</identifier><identifier>EISSN: 1873-6246</identifier><identifier>DOI: 10.1016/j.biopsycho.2012.03.016</identifier><identifier>PMID: 22504296</identifier><identifier>CODEN: BLPYAX</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult and adolescent clinical studies ; Analysis of Variance ; Autonomic nervous system ; Autonomic Nervous System - physiopathology ; Behavioral psychophysiology ; Biological and medical sciences ; Cardiac autonomic function ; Cardiovascular diseases ; Case-Control Studies ; Depression ; Depressive Disorder, Major - physiopathology ; Diagnostic and Statistical Manual of Mental Disorders ; Electrocardiography ; Female ; Fundamental and applied biological sciences. Psychology ; Heart ; Heart - innervation ; Heart - physiopathology ; Heart diseases ; Heart rate ; Heart Rate - physiology ; Heart rate variability ; Hispanic Americans ; Humans ; Hypotension, Orthostatic - physiopathology ; Linear Models ; Major depression ; Male ; Medical sciences ; Mental disorders ; Mood disorders ; Morbidity ; Multivariate Analysis ; Parasympathetic nervous system ; Physical Examination ; Psychiatric Status Rating Scales ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. Psychiatry ; Sex Characteristics ; Sex differences ; Stress ; Supine Position - physiology ; Young Adult</subject><ispartof>Biological psychology, 2012-07, Vol.90 (3), p.179-185</ispartof><rights>2012 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-4661d6707d94c436b29ef7fb8f5f0c3e8159104dc13117780cb3cc4d57e6fc603</citedby><cites>FETCH-LOGICAL-c434t-4661d6707d94c436b29ef7fb8f5f0c3e8159104dc13117780cb3cc4d57e6fc603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biopsycho.2012.03.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26043516$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22504296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia, R.G.</creatorcontrib><creatorcontrib>Zarruk, J.G.</creatorcontrib><creatorcontrib>Guzman, J.C.</creatorcontrib><creatorcontrib>Barrera, C.</creatorcontrib><creatorcontrib>Pinzon, A.</creatorcontrib><creatorcontrib>Trillos, E.</creatorcontrib><creatorcontrib>Lopez-Jaramillo, P.</creatorcontrib><creatorcontrib>Morillo, C.A.</creatorcontrib><creatorcontrib>Maior, R.S.</creatorcontrib><creatorcontrib>Diaz-Quijano, F.A.</creatorcontrib><creatorcontrib>Tomaz, C.</creatorcontrib><title>Sex differences in cardiac autonomic function of depressed young adults</title><title>Biological psychology</title><addtitle>Biol Psychol</addtitle><description>► Heart rate variability of depressed adults under orthostatic stress was examined. ► Depressed males showed reduced HRV and parasympathetic activity. ► Reduced HRV and increased LF/HF in males linked to higher cardiovascular risk. ► The relationship between depression and cardiac dysfunction may be sex-dependent.
Cardiac autonomic dysfunction has been proposed as an important contributing factor to the increased cardiovascular risk observed in major depression (MDD). However, the evidence regarding alterations in heart rate variability (HRV) in otherwise healthy depressed subjects has been inconclusive.
A case–control study in 50 treatment-naïve young adults with a first MDD episode without comorbid psychiatric disorders and 50 healthy control subjects was conducted. Time- and frequency-domain indexes of HRV were determined at baseline supine and after 5-min of orthostatic stress at 60°.
There were no significant differences in the time- or frequency-domain variables of HRV between depressed patients and controls. However, a random-effect ANOVA model showed that during orthostatic stress depressed men had a reduced HRV and decreased parasympathetic activity compared to control subjects, while no differences were found between depressed women and controls.
These results suggest a sex-dependent relationship between major depression and cardiac autonomic dysfunction and provide one potential explanation for sex differences in the association of depressive symptoms with cardiovascular morbidity.</description><subject>Adult and adolescent clinical studies</subject><subject>Analysis of Variance</subject><subject>Autonomic nervous system</subject><subject>Autonomic Nervous System - physiopathology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Cardiac autonomic function</subject><subject>Cardiovascular diseases</subject><subject>Case-Control Studies</subject><subject>Depression</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Diagnostic and Statistical Manual of Mental Disorders</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart</subject><subject>Heart - innervation</subject><subject>Heart - physiopathology</subject><subject>Heart diseases</subject><subject>Heart rate</subject><subject>Heart Rate - physiology</subject><subject>Heart rate variability</subject><subject>Hispanic Americans</subject><subject>Humans</subject><subject>Hypotension, Orthostatic - physiopathology</subject><subject>Linear Models</subject><subject>Major depression</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental disorders</subject><subject>Mood disorders</subject><subject>Morbidity</subject><subject>Multivariate Analysis</subject><subject>Parasympathetic nervous system</subject><subject>Physical Examination</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Sex Characteristics</subject><subject>Sex differences</subject><subject>Stress</subject><subject>Supine Position - physiology</subject><subject>Young Adult</subject><issn>0301-0511</issn><issn>1873-6246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EotvCX4BckLgkjOOPZI9VVQpSpR7ani1nPAavsvFiJ6j77_GySznCaaxXz3zoMWPvOTQcuP60aYYQd3mP32PTAm8bEE3JX7AV7ztR61bql2wFAngNivMzdp7zBqC8lXrNztpWgWzXesVu7umpcsF7SjQh5SpMFdrkgsXKLnOc4jZg5ZcJ5xCnKvrK0S5RzuSqfVymb5V1yzjnN-yVt2Omt6d6wR4_Xz9cfalv726-Xl3e1iiFnGupNXe6g86tZUn00K7Jd37ovfKAgnqu1hykQy4477oecBCI0qmOtEcN4oJ9PM7dpfhjoTybbchI42gniks2HESvuWq5-A-0BZB9r7qCdkcUU8w5kTe7FLY27QtkDsLNxjwLNwfhBoQpeel8d1qyDFtyz31_DBfgwwmwGe3ok50w5L-cBinU70GXR46KvZ-BkskYDl_iQiKcjYvhn8f8Al5Pofw</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Garcia, R.G.</creator><creator>Zarruk, J.G.</creator><creator>Guzman, J.C.</creator><creator>Barrera, C.</creator><creator>Pinzon, A.</creator><creator>Trillos, E.</creator><creator>Lopez-Jaramillo, P.</creator><creator>Morillo, C.A.</creator><creator>Maior, R.S.</creator><creator>Diaz-Quijano, F.A.</creator><creator>Tomaz, C.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20120701</creationdate><title>Sex differences in cardiac autonomic function of depressed young adults</title><author>Garcia, R.G. ; Zarruk, J.G. ; Guzman, J.C. ; Barrera, C. ; Pinzon, A. ; Trillos, E. ; Lopez-Jaramillo, P. ; Morillo, C.A. ; Maior, R.S. ; Diaz-Quijano, F.A. ; Tomaz, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-4661d6707d94c436b29ef7fb8f5f0c3e8159104dc13117780cb3cc4d57e6fc603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Analysis of Variance</topic><topic>Autonomic nervous system</topic><topic>Autonomic Nervous System - physiopathology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Cardiac autonomic function</topic><topic>Cardiovascular diseases</topic><topic>Case-Control Studies</topic><topic>Depression</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Diagnostic and Statistical Manual of Mental Disorders</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart</topic><topic>Heart - innervation</topic><topic>Heart - physiopathology</topic><topic>Heart diseases</topic><topic>Heart rate</topic><topic>Heart Rate - physiology</topic><topic>Heart rate variability</topic><topic>Hispanic Americans</topic><topic>Humans</topic><topic>Hypotension, Orthostatic - physiopathology</topic><topic>Linear Models</topic><topic>Major depression</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental disorders</topic><topic>Mood disorders</topic><topic>Morbidity</topic><topic>Multivariate Analysis</topic><topic>Parasympathetic nervous system</topic><topic>Physical Examination</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Sex Characteristics</topic><topic>Sex differences</topic><topic>Stress</topic><topic>Supine Position - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia, R.G.</creatorcontrib><creatorcontrib>Zarruk, J.G.</creatorcontrib><creatorcontrib>Guzman, J.C.</creatorcontrib><creatorcontrib>Barrera, C.</creatorcontrib><creatorcontrib>Pinzon, A.</creatorcontrib><creatorcontrib>Trillos, E.</creatorcontrib><creatorcontrib>Lopez-Jaramillo, P.</creatorcontrib><creatorcontrib>Morillo, C.A.</creatorcontrib><creatorcontrib>Maior, R.S.</creatorcontrib><creatorcontrib>Diaz-Quijano, F.A.</creatorcontrib><creatorcontrib>Tomaz, C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Biological psychology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia, R.G.</au><au>Zarruk, J.G.</au><au>Guzman, J.C.</au><au>Barrera, C.</au><au>Pinzon, A.</au><au>Trillos, E.</au><au>Lopez-Jaramillo, P.</au><au>Morillo, C.A.</au><au>Maior, R.S.</au><au>Diaz-Quijano, F.A.</au><au>Tomaz, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex differences in cardiac autonomic function of depressed young adults</atitle><jtitle>Biological psychology</jtitle><addtitle>Biol Psychol</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>90</volume><issue>3</issue><spage>179</spage><epage>185</epage><pages>179-185</pages><issn>0301-0511</issn><eissn>1873-6246</eissn><coden>BLPYAX</coden><abstract>► Heart rate variability of depressed adults under orthostatic stress was examined. ► Depressed males showed reduced HRV and parasympathetic activity. ► Reduced HRV and increased LF/HF in males linked to higher cardiovascular risk. ► The relationship between depression and cardiac dysfunction may be sex-dependent.
Cardiac autonomic dysfunction has been proposed as an important contributing factor to the increased cardiovascular risk observed in major depression (MDD). However, the evidence regarding alterations in heart rate variability (HRV) in otherwise healthy depressed subjects has been inconclusive.
A case–control study in 50 treatment-naïve young adults with a first MDD episode without comorbid psychiatric disorders and 50 healthy control subjects was conducted. Time- and frequency-domain indexes of HRV were determined at baseline supine and after 5-min of orthostatic stress at 60°.
There were no significant differences in the time- or frequency-domain variables of HRV between depressed patients and controls. However, a random-effect ANOVA model showed that during orthostatic stress depressed men had a reduced HRV and decreased parasympathetic activity compared to control subjects, while no differences were found between depressed women and controls.
These results suggest a sex-dependent relationship between major depression and cardiac autonomic dysfunction and provide one potential explanation for sex differences in the association of depressive symptoms with cardiovascular morbidity.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>22504296</pmid><doi>10.1016/j.biopsycho.2012.03.016</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies Analysis of Variance Autonomic nervous system Autonomic Nervous System - physiopathology Behavioral psychophysiology Biological and medical sciences Cardiac autonomic function Cardiovascular diseases Case-Control Studies Depression Depressive Disorder, Major - physiopathology Diagnostic and Statistical Manual of Mental Disorders Electrocardiography Female Fundamental and applied biological sciences. Psychology Heart Heart - innervation Heart - physiopathology Heart diseases Heart rate Heart Rate - physiology Heart rate variability Hispanic Americans Humans Hypotension, Orthostatic - physiopathology Linear Models Major depression Male Medical sciences Mental disorders Mood disorders Morbidity Multivariate Analysis Parasympathetic nervous system Physical Examination Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Sex Characteristics Sex differences Stress Supine Position - physiology Young Adult |
| title | Sex differences in cardiac autonomic function of depressed young adults |
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