Chronic exposure to corticosterone enhances the neuroinflammatory and neurotoxic responses to methamphetamine

J. Neurochem. (2012) 122, 995–1009. Up‐regulation of proinflammatory cytokines and chemokines in brain (“neuroinflammation”) accompanies neurological disease and neurotoxicity. Previously, we documented a striatal neuroinflammatory response to acute administration of a neurotoxic dose of methampheta...

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Veröffentlicht in:	Journal of neurochemistry 2012-09, Vol.122 (5), p.995-1009
Hauptverfasser:	Kelly, Kimberly A., Miller, Diane B., Bowyer, John F., O'Callaghan, James P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcoholism and acute alcohol poisoning Amphetamine Analysis of Variance Animals Anti-Inflammatory Agents - adverse effects Biological and medical sciences Body Weight - drug effects Brain Brain - drug effects Brain - metabolism Brain - pathology Central nervous system Central Nervous System Stimulants - toxicity Chemokines Chromatography, High Pressure Liquid - methods Cortex (frontal) Corticosterone Corticosterone - adverse effects Cytokines Cytokines - genetics Cytokines - metabolism Disease Models, Animal Dopamine Dopamine - metabolism Dose-Response Relationship, Drug Drinking water Drug addictions Drug Synergism Electrochemical Techniques - methods Encephalitis - chemically induced Encephalitis - metabolism Encephalitis - physiopathology Enzyme-Linked Immunosorbent Assay Glial Fibrillary Acidic Protein - metabolism Gliosis Glucocorticoids Hippocampus Hypertrophy Inflammation Lectins Male Medical sciences Methamphetamine Methamphetamine - toxicity Mice Mice, Inbred C57BL Microglia - drug effects Microglia - metabolism microglial activation Neostriatum Nerve endings Neurochemistry neuroinflammation Neurological disorders Neurotoxicity Steroids Stress Time Factors Toxicity Toxicology Tyrosine 3-Monooxygenase - metabolism Up-Regulation - drug effects
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