Peptide-based delivery to bone
Peptides are attractive as novel therapeutic reagents, since they are flexible in adopting and mimicking the local structural features of proteins. Versatile capabilities to perform organic synthetic manipulations are another unique feature of peptides compared to protein-based medicines, such as an...
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| Veröffentlicht in: | Advanced drug delivery reviews 2012-09, Vol.64 (12), p.1220-1238 |
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| container_title | Advanced drug delivery reviews |
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| creator | Aoki, Kazuhiro Alles, Neil Soysa, Niroshani Ohya, Keiichi |
| description | Peptides are attractive as novel therapeutic reagents, since they are flexible in adopting and mimicking the local structural features of proteins. Versatile capabilities to perform organic synthetic manipulations are another unique feature of peptides compared to protein-based medicines, such as antibodies. On the other hand, a disadvantage of using a peptide for a therapeutic purpose is its low stability and/or high level of aggregation. During the past two decades, numerous peptides were developed for the treatment of bone diseases, and some peptides have already been used for local applications to repair bone defects in the clinic. However, very few peptides have the ability to form bone themselves. We herein summarize the effects of the therapeutic peptides on bone loss and/or local bone defects, including the results from basic studies. We also herein describe some possible methods for overcoming the obstacles associated with using therapeutic peptide candidates.
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| doi_str_mv | 10.1016/j.addr.2012.05.017 |
| format | Article |
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[Display omitted]</description><subject>Animals</subject><subject>Antagonist</subject><subject>Antibodies</subject><subject>BMP</subject><subject>Bone and Bones - metabolism</subject><subject>Bone Diseases - drug therapy</subject><subject>Bone Diseases - pathology</subject><subject>Bone formation stimulatory peptide</subject><subject>Bone resorption inhibitory peptide</subject><subject>Bone-targeting peptide</subject><subject>Cholesterol-bearing pullulan (CHP) nanogel</subject><subject>Collagen</subject><subject>Drug Delivery Systems</subject><subject>Drug Design</subject><subject>Half-life</subject><subject>Humans</subject><subject>Peptides - administration & dosage</subject><subject>Peptides - pharmacology</subject><subject>Peptides - therapeutic use</subject><subject>Protein Stability</subject><subject>RANKL (receptor activator of NF-κB ligand)</subject><subject>Stability</subject><subject>Thrombin</subject><issn>0169-409X</issn><issn>1872-8294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0M1KAzEUhuEgiq3VG3BRunQz40kmmSTgRop_UNCFgruQSc5AStupybTQuzel1aW4OpvnfIuXkGsKJQVa385L630sGVBWgiiByhMypEqyQjHNT8kwI11w0J8DcpHSHDKUNZyTAWMSdM31kIzfcN0Hj0VjE_qJx0XYYtxN-m7SdCu8JGetXSS8Ot4R-Xh8eJ8-F7PXp5fp_axwldJ9oSWVTWU5BUtBA7MNr7StrRNeMA5cKPCVV0xxKZ22glvtUFvpXYuq1XU1IjeH3XXsvjaYerMMyeFiYVfYbZKhUKmaslrQ_1AutapAZMoO1MUupYitWcewtHGXkdknNHOzT2j2CQ0IkxPmp_Fxf9Ms0f--_DTL4O4AMAfZBowmuYArhz5EdL3xXfhr_xvfgH8m</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Aoki, Kazuhiro</creator><creator>Alles, Neil</creator><creator>Soysa, Niroshani</creator><creator>Ohya, Keiichi</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201209</creationdate><title>Peptide-based delivery to bone</title><author>Aoki, Kazuhiro ; Alles, Neil ; Soysa, Niroshani ; Ohya, Keiichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-9717b3a410a10902ab439a6ac5d52404580d3d828477c9a54a9ce9a7dcfe8f963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Antagonist</topic><topic>Antibodies</topic><topic>BMP</topic><topic>Bone and Bones - metabolism</topic><topic>Bone Diseases - drug therapy</topic><topic>Bone Diseases - pathology</topic><topic>Bone formation stimulatory peptide</topic><topic>Bone resorption inhibitory peptide</topic><topic>Bone-targeting peptide</topic><topic>Cholesterol-bearing pullulan (CHP) nanogel</topic><topic>Collagen</topic><topic>Drug Delivery Systems</topic><topic>Drug Design</topic><topic>Half-life</topic><topic>Humans</topic><topic>Peptides - administration & dosage</topic><topic>Peptides - pharmacology</topic><topic>Peptides - therapeutic use</topic><topic>Protein Stability</topic><topic>RANKL (receptor activator of NF-κB ligand)</topic><topic>Stability</topic><topic>Thrombin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aoki, Kazuhiro</creatorcontrib><creatorcontrib>Alles, Neil</creatorcontrib><creatorcontrib>Soysa, Niroshani</creatorcontrib><creatorcontrib>Ohya, Keiichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Advanced drug delivery reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aoki, Kazuhiro</au><au>Alles, Neil</au><au>Soysa, Niroshani</au><au>Ohya, Keiichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peptide-based delivery to bone</atitle><jtitle>Advanced drug delivery reviews</jtitle><addtitle>Adv Drug Deliv Rev</addtitle><date>2012-09</date><risdate>2012</risdate><volume>64</volume><issue>12</issue><spage>1220</spage><epage>1238</epage><pages>1220-1238</pages><issn>0169-409X</issn><eissn>1872-8294</eissn><abstract>Peptides are attractive as novel therapeutic reagents, since they are flexible in adopting and mimicking the local structural features of proteins. 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| identifier | ISSN: 0169-409X |
| ispartof | Advanced drug delivery reviews, 2012-09, Vol.64 (12), p.1220-1238 |
| issn | 0169-409X 1872-8294 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antagonist Antibodies BMP Bone and Bones - metabolism Bone Diseases - drug therapy Bone Diseases - pathology Bone formation stimulatory peptide Bone resorption inhibitory peptide Bone-targeting peptide Cholesterol-bearing pullulan (CHP) nanogel Collagen Drug Delivery Systems Drug Design Half-life Humans Peptides - administration & dosage Peptides - pharmacology Peptides - therapeutic use Protein Stability RANKL (receptor activator of NF-κB ligand) Stability Thrombin |
| title | Peptide-based delivery to bone |
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