Prevention of High-Mobility Group Box 1-Mediated Early Loss of Transplanted Mouse Islets in the Liver by Antithrombin III

The low efficiency of pancreatic islet transplantation mainly because of the early loss of transplanted islets hampers its clinical application. Previously, we have shown in mice that the early loss of transplanted islets in the liver is caused by innate immune rejection in concert with dendritic ce...

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Veröffentlicht in:	Transplantation 2012-05, Vol.93 (10), p.983-988
Hauptverfasser:	KOJIMA, Daibo, MERA, Toshiyuki, NISHINAKAMURA, Hitomi, ITOH, Takeshi, OGATA, Takako, MATSUOKA, Nobuhide, KODAMA, Shohta, YASUNAMI, Yohichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antithrombin III - pharmacology Biological and medical sciences CD4 Antigens - physiology Diabetes Mellitus, Experimental - surgery Fundamental and applied biological sciences. Psychology Fundamental immunology HMGB1 Protein - physiology Interferon-gamma - biosynthesis Islets of Langerhans Transplantation Liver - immunology Male Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Natural Killer T-Cells - immunology Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine Streptozocin Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Thrombomodulin - physiology Tissue, organ and graft immunology
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