Role of T-cell-specific nuclear factor κB in islet allograft rejection

Pancreatic islet transplantation has the potential to cure type 1 diabetes, a chronic lifelong disease, but its clinical applicability is limited by allograft rejection. Nuclear factor κB (NF-κB) is a transcription factor important for survival and differentiation of T cells. In this study, we teste...

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Veröffentlicht in:	Transplantation 2012-05, Vol.93 (10), p.976-982
Hauptverfasser:	Porras, Delia Lozano, Wang, Ying, Zhou, Ping, Molinero, Luciana L, Alegre, Maria-Luisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts Animals CARD Signaling Adaptor Proteins - physiology CD4 antigen Cell activation Cell survival Data processing Diabetes mellitus Differentiation Graft rejection Graft Rejection - etiology Graft Survival Immune Tolerance Immunofluorescence Immunological tolerance Islet cells Islets of Langerhans Islets of Langerhans Transplantation - immunology Isoantigens - immunology Lymphocytes B Lymphocytes T Mice Mice, Inbred BALB C Mice, Inbred C3H NF- Kappa B protein NF-kappa B - antagonists & inhibitors NF-kappa B - physiology Pancreas Pancreatic islet transplantation Skin T-cell receptor T-Lymphocytes - immunology Transcription factors Transplantation Transplantation, Homologous
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