d-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis

d-Limonene, a common monoterepene has been shown to have antiproliferative, apoptosis-inducing and chemopreventive effects. In the present study, we have investigated the effects of d-limonene on the growth of 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate (...

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Veröffentlicht in:	Human & experimental toxicology 2012-08, Vol.31 (8), p.798-811
Hauptverfasser:	Chaudhary, SC, Siddiqui, MS, Athar, M, Alam, M Sarwar
Format:	Artikel
Sprache:	eng
Schlagworte:	12-O-Tetradecanoylphorbol-13-acetate 9,10-Dimethyl-1,2-benzanthracene Animal models Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Bax protein Bcl-2 protein Biological and medical sciences Body weight Carcinogenesis, carcinogens and anticarcinogens Carcinogens Catalase Catalase - metabolism Chemical agents Cyclohexenes - pharmacology Cyclohexenes - therapeutic use Cyclooxygenase 2 - metabolism Cyclooxygenase-2 DNA Edema Female Glutathione - metabolism Glutathione peroxidase glutathione reductase Glutathione transferase Hyperplasia Inflammation Inflammation - drug therapy Inflammation - pathology Limonene Malondialdehyde Medical sciences Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Ornithine decarboxylase Oxidative stress Oxidative Stress - drug effects Phosphorylation Protein kinase raf Kinases - metabolism Raf protein Ras protein ras Proteins - metabolism Rodents Signal Transduction - drug effects Skin cancer Skin Neoplasms - chemically induced Skin Neoplasms - metabolism Skin Neoplasms - pathology Skin Neoplasms - prevention & control Terpenes - pharmacology Terpenes - therapeutic use Tetradecanoylphorbol Acetate Thymidine Toxicology Tumorigenesis Tumors
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