Patterns of subsequent malignancies after Hodgkin lymphoma in children and adults
Summary To evaluate the impact of reduced radiation and combined modality therapy (CMT) in the treatment of Hodgkin lymphoma, we assessed the risk of second malignant neoplasms (SMNs) in patients who received extended‐field radiotherapy only and patients who underwent CMT. Among 404 patients treated...
Gespeichert in:
| Veröffentlicht in: | British journal of haematology 2012-09, Vol.158 (5), p.615-625 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 625 |
|---|---|
| container_issue | 5 |
| container_start_page | 615 |
| container_title | British journal of haematology |
| container_volume | 158 |
| creator | Omer, Bilal Kadan-Lottick, Nina S. Roberts, Kenneth B. Wang, Rong Demsky, Carolyn Kupfer, Gary M. Cooper, Dennis Seropian, Stuart Ma, Xiaomei |
| description | Summary
To evaluate the impact of reduced radiation and combined modality therapy (CMT) in the treatment of Hodgkin lymphoma, we assessed the risk of second malignant neoplasms (SMNs) in patients who received extended‐field radiotherapy only and patients who underwent CMT. Among 404 patients treated at Yale during 1970–2004, the risk of solid SMNs was elevated in the radiotherapy only group (n = 198, median follow‐up = 21·1 years) compared to the general population, with a standardized incidence ratio (SIR) of 1·85 [95% confidence interval (CI): 1·17–2·78]. No increase was observed in the CMT group (n = 206, median follow‐up = 14·3 years), although potential differences in SMN risk were indicated across the age spectrum in subgroup analysis. Patients who received mustard‐containing regimens had increased risks for haematological SMNs (SIR = 8·74) and all SMNs (SIR = 1·85). When the analysis was stratified by age at diagnosis, children (0–20 years) had a significantly higher risk of SMNs (SIR = 5·24, 95% CI: 2·26–10·33), regardless of the treatment received. These findings suggest that recent treatment options utilizing lower dose radiation and less intense alkylator chemotherapy might be associated with lower incidences of SMNs among adults but not necessarily children. |
| doi_str_mv | 10.1111/j.1365-2141.2012.09211.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1038610902</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1038610902</sourcerecordid><originalsourceid>FETCH-LOGICAL-i4161-ecd6054c979398954fb90e6614fba97d28a54e50c3d8f6189e39e321fc266fe53</originalsourceid><addsrcrecordid>eNqNkUFv1DAQhS0Eokvbv4B8QeKSMGPHTnzgAC10i1bQVi0cLW_itN46yTZOxO6_x-kuy5WRpXnSfM8azSOEIqQY68MqRS5FwjDDlAGyFBRDTDcvyOwweElmAJAnCFlxRN6EsAJADgJfkyPG8lwI5DNyfWWGwfZtoF1Nw7gM9mm07UAb4919a9rS2UBNHRE676r7R9dSv23WD11jaNTlg_NVb1tq2oqaavRDOCGvauODPd33Y3L39cvt2TxZ_Li4PPu0SFyGEhNbVhJEVqpccVUokdVLBVZKjMKovGKFEZkVUPKqqCUWyvL4GNYlk7K2gh-T97t_130Xdw6Dblworfemtd0YNAIvJIIC9j8oz4SUrIjo2z06Lhtb6XXvGtNv9d-LReDdHjChNL7upxuFf5xkkWPTeh933G_n7fYwR9BTgnqlp6D0FJSeEtTPCeqN_vxtPqnoT3Z-Fwa7OfhN_6hlznOhf32_0Dkubm7Pz4X-yf8ApR6cGg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1033456628</pqid></control><display><type>article</type><title>Patterns of subsequent malignancies after Hodgkin lymphoma in children and adults</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><source>Wiley Online Library All Journals</source><creator>Omer, Bilal ; Kadan-Lottick, Nina S. ; Roberts, Kenneth B. ; Wang, Rong ; Demsky, Carolyn ; Kupfer, Gary M. ; Cooper, Dennis ; Seropian, Stuart ; Ma, Xiaomei</creator><creatorcontrib>Omer, Bilal ; Kadan-Lottick, Nina S. ; Roberts, Kenneth B. ; Wang, Rong ; Demsky, Carolyn ; Kupfer, Gary M. ; Cooper, Dennis ; Seropian, Stuart ; Ma, Xiaomei</creatorcontrib><description>Summary
To evaluate the impact of reduced radiation and combined modality therapy (CMT) in the treatment of Hodgkin lymphoma, we assessed the risk of second malignant neoplasms (SMNs) in patients who received extended‐field radiotherapy only and patients who underwent CMT. Among 404 patients treated at Yale during 1970–2004, the risk of solid SMNs was elevated in the radiotherapy only group (n = 198, median follow‐up = 21·1 years) compared to the general population, with a standardized incidence ratio (SIR) of 1·85 [95% confidence interval (CI): 1·17–2·78]. No increase was observed in the CMT group (n = 206, median follow‐up = 14·3 years), although potential differences in SMN risk were indicated across the age spectrum in subgroup analysis. Patients who received mustard‐containing regimens had increased risks for haematological SMNs (SIR = 8·74) and all SMNs (SIR = 1·85). When the analysis was stratified by age at diagnosis, children (0–20 years) had a significantly higher risk of SMNs (SIR = 5·24, 95% CI: 2·26–10·33), regardless of the treatment received. These findings suggest that recent treatment options utilizing lower dose radiation and less intense alkylator chemotherapy might be associated with lower incidences of SMNs among adults but not necessarily children.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/j.1365-2141.2012.09211.x</identifier><identifier>PMID: 22775513</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Age ; Age of Onset ; Aged ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Chemotherapy ; Child ; Child, Preschool ; Children ; combined modality therapy ; Female ; Follow-Up Studies ; Hematologic and hematopoietic diseases ; Hodgkin ; Hodgkin Disease - drug therapy ; Hodgkin Disease - radiotherapy ; Hodgkin's disease ; Humans ; Infant ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma ; Male ; Malignancy ; Medical sciences ; Middle Aged ; Neoplasms, Second Primary - etiology ; Radiation ; Radiotherapy ; Radiotherapy Dosage ; Risk Factors ; second malignant neoplasms ; Treatment Outcome ; Young Adult</subject><ispartof>British journal of haematology, 2012-09, Vol.158 (5), p.615-625</ispartof><rights>2012 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2012 Blackwell Publishing Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2141.2012.09211.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2141.2012.09211.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26275525$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22775513$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Omer, Bilal</creatorcontrib><creatorcontrib>Kadan-Lottick, Nina S.</creatorcontrib><creatorcontrib>Roberts, Kenneth B.</creatorcontrib><creatorcontrib>Wang, Rong</creatorcontrib><creatorcontrib>Demsky, Carolyn</creatorcontrib><creatorcontrib>Kupfer, Gary M.</creatorcontrib><creatorcontrib>Cooper, Dennis</creatorcontrib><creatorcontrib>Seropian, Stuart</creatorcontrib><creatorcontrib>Ma, Xiaomei</creatorcontrib><title>Patterns of subsequent malignancies after Hodgkin lymphoma in children and adults</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
To evaluate the impact of reduced radiation and combined modality therapy (CMT) in the treatment of Hodgkin lymphoma, we assessed the risk of second malignant neoplasms (SMNs) in patients who received extended‐field radiotherapy only and patients who underwent CMT. Among 404 patients treated at Yale during 1970–2004, the risk of solid SMNs was elevated in the radiotherapy only group (n = 198, median follow‐up = 21·1 years) compared to the general population, with a standardized incidence ratio (SIR) of 1·85 [95% confidence interval (CI): 1·17–2·78]. No increase was observed in the CMT group (n = 206, median follow‐up = 14·3 years), although potential differences in SMN risk were indicated across the age spectrum in subgroup analysis. Patients who received mustard‐containing regimens had increased risks for haematological SMNs (SIR = 8·74) and all SMNs (SIR = 1·85). When the analysis was stratified by age at diagnosis, children (0–20 years) had a significantly higher risk of SMNs (SIR = 5·24, 95% CI: 2·26–10·33), regardless of the treatment received. These findings suggest that recent treatment options utilizing lower dose radiation and less intense alkylator chemotherapy might be associated with lower incidences of SMNs among adults but not necessarily children.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>combined modality therapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hodgkin</subject><subject>Hodgkin Disease - drug therapy</subject><subject>Hodgkin Disease - radiotherapy</subject><subject>Hodgkin's disease</subject><subject>Humans</subject><subject>Infant</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma</subject><subject>Male</subject><subject>Malignancy</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasms, Second Primary - etiology</subject><subject>Radiation</subject><subject>Radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Risk Factors</subject><subject>second malignant neoplasms</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFv1DAQhS0Eokvbv4B8QeKSMGPHTnzgAC10i1bQVi0cLW_itN46yTZOxO6_x-kuy5WRpXnSfM8azSOEIqQY68MqRS5FwjDDlAGyFBRDTDcvyOwweElmAJAnCFlxRN6EsAJADgJfkyPG8lwI5DNyfWWGwfZtoF1Nw7gM9mm07UAb4919a9rS2UBNHRE676r7R9dSv23WD11jaNTlg_NVb1tq2oqaavRDOCGvauODPd33Y3L39cvt2TxZ_Li4PPu0SFyGEhNbVhJEVqpccVUokdVLBVZKjMKovGKFEZkVUPKqqCUWyvL4GNYlk7K2gh-T97t_130Xdw6Dblworfemtd0YNAIvJIIC9j8oz4SUrIjo2z06Lhtb6XXvGtNv9d-LReDdHjChNL7upxuFf5xkkWPTeh933G_n7fYwR9BTgnqlp6D0FJSeEtTPCeqN_vxtPqnoT3Z-Fwa7OfhN_6hlznOhf32_0Dkubm7Pz4X-yf8ApR6cGg</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Omer, Bilal</creator><creator>Kadan-Lottick, Nina S.</creator><creator>Roberts, Kenneth B.</creator><creator>Wang, Rong</creator><creator>Demsky, Carolyn</creator><creator>Kupfer, Gary M.</creator><creator>Cooper, Dennis</creator><creator>Seropian, Stuart</creator><creator>Ma, Xiaomei</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201209</creationdate><title>Patterns of subsequent malignancies after Hodgkin lymphoma in children and adults</title><author>Omer, Bilal ; Kadan-Lottick, Nina S. ; Roberts, Kenneth B. ; Wang, Rong ; Demsky, Carolyn ; Kupfer, Gary M. ; Cooper, Dennis ; Seropian, Stuart ; Ma, Xiaomei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i4161-ecd6054c979398954fb90e6614fba97d28a54e50c3d8f6189e39e321fc266fe53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>combined modality therapy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hodgkin</topic><topic>Hodgkin Disease - drug therapy</topic><topic>Hodgkin Disease - radiotherapy</topic><topic>Hodgkin's disease</topic><topic>Humans</topic><topic>Infant</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma</topic><topic>Male</topic><topic>Malignancy</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasms, Second Primary - etiology</topic><topic>Radiation</topic><topic>Radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Risk Factors</topic><topic>second malignant neoplasms</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Omer, Bilal</creatorcontrib><creatorcontrib>Kadan-Lottick, Nina S.</creatorcontrib><creatorcontrib>Roberts, Kenneth B.</creatorcontrib><creatorcontrib>Wang, Rong</creatorcontrib><creatorcontrib>Demsky, Carolyn</creatorcontrib><creatorcontrib>Kupfer, Gary M.</creatorcontrib><creatorcontrib>Cooper, Dennis</creatorcontrib><creatorcontrib>Seropian, Stuart</creatorcontrib><creatorcontrib>Ma, Xiaomei</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Omer, Bilal</au><au>Kadan-Lottick, Nina S.</au><au>Roberts, Kenneth B.</au><au>Wang, Rong</au><au>Demsky, Carolyn</au><au>Kupfer, Gary M.</au><au>Cooper, Dennis</au><au>Seropian, Stuart</au><au>Ma, Xiaomei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of subsequent malignancies after Hodgkin lymphoma in children and adults</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2012-09</date><risdate>2012</risdate><volume>158</volume><issue>5</issue><spage>615</spage><epage>625</epage><pages>615-625</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Summary
To evaluate the impact of reduced radiation and combined modality therapy (CMT) in the treatment of Hodgkin lymphoma, we assessed the risk of second malignant neoplasms (SMNs) in patients who received extended‐field radiotherapy only and patients who underwent CMT. Among 404 patients treated at Yale during 1970–2004, the risk of solid SMNs was elevated in the radiotherapy only group (n = 198, median follow‐up = 21·1 years) compared to the general population, with a standardized incidence ratio (SIR) of 1·85 [95% confidence interval (CI): 1·17–2·78]. No increase was observed in the CMT group (n = 206, median follow‐up = 14·3 years), although potential differences in SMN risk were indicated across the age spectrum in subgroup analysis. Patients who received mustard‐containing regimens had increased risks for haematological SMNs (SIR = 8·74) and all SMNs (SIR = 1·85). When the analysis was stratified by age at diagnosis, children (0–20 years) had a significantly higher risk of SMNs (SIR = 5·24, 95% CI: 2·26–10·33), regardless of the treatment received. These findings suggest that recent treatment options utilizing lower dose radiation and less intense alkylator chemotherapy might be associated with lower incidences of SMNs among adults but not necessarily children.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>22775513</pmid><doi>10.1111/j.1365-2141.2012.09211.x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1048 |
| ispartof | British journal of haematology, 2012-09, Vol.158 (5), p.615-625 |
| issn | 0007-1048 1365-2141 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1038610902 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Wiley Online Library All Journals |
| subjects | Adolescent Adult Age Age of Onset Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Chemotherapy Child Child, Preschool Children combined modality therapy Female Follow-Up Studies Hematologic and hematopoietic diseases Hodgkin Hodgkin Disease - drug therapy Hodgkin Disease - radiotherapy Hodgkin's disease Humans Infant Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma Male Malignancy Medical sciences Middle Aged Neoplasms, Second Primary - etiology Radiation Radiotherapy Radiotherapy Dosage Risk Factors second malignant neoplasms Treatment Outcome Young Adult |
| title | Patterns of subsequent malignancies after Hodgkin lymphoma in children and adults |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T07%3A21%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Patterns%20of%20subsequent%20malignancies%20after%20Hodgkin%20lymphoma%20in%20children%20and%20adults&rft.jtitle=British%20journal%20of%20haematology&rft.au=Omer,%20Bilal&rft.date=2012-09&rft.volume=158&rft.issue=5&rft.spage=615&rft.epage=625&rft.pages=615-625&rft.issn=0007-1048&rft.eissn=1365-2141&rft.coden=BJHEAL&rft_id=info:doi/10.1111/j.1365-2141.2012.09211.x&rft_dat=%3Cproquest_pubme%3E1038610902%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1033456628&rft_id=info:pmid/22775513&rfr_iscdi=true |