Ectopic expression of CDX4 in human mesenchymal stem cells does not affect HOX gene expression or induce hematopoietic reprogramming

In vitro generation of large numbers of autologous hematopoietic stem cells would be extremely useful for clinical applications. Adipose tissue derived mesenchymal stem cells (AT-MSC) are an easily available autologous source for cell therapy applications. Like hematopoietic cells, MSC are of mesode...

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Veröffentlicht in:	Stem cell research 2012-09, Vol.9 (2), p.135-142
Hauptverfasser:	Szöke, Krisztina, Beckstrøm, Karen Johanne, Brinchmann, Jan E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adolescent Adult Autografts Bone Morphogenetic Protein 4 - pharmacology Cell Shape - drug effects Cellular Reprogramming - drug effects Cellular Reprogramming - genetics Colonies Colony-Forming Units Assay Cytokines Cytokines - pharmacology Epigenesis, Genetic - drug effects epigenetics Flow Cytometry Gene Expression Regulation - drug effects Green Fluorescent Proteins - metabolism Growth factors Hematopoiesis - drug effects Hematopoiesis - genetics Hemopoiesis Homeodomain Proteins - genetics Homeodomain Proteins - metabolism HOX gene Humans Immunohistochemistry Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Mesenchyme Real-Time Polymerase Chain Reaction Retroviridae - genetics Stem cells Therapeutic applications Transcription factors Transduction, Genetic Young Adult
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