Diverse Effects of Cyclic AMP Variants on Osteogenic and Adipogenic Differentiation of Human Mesenchymal Stromal Cells

Osteogenic differentiation of human mesenchymal stromal cells (hMSCs) may potentially be used in cell-based bone tissue-engineering applications to enhance the bone-forming potential of these cells. Osteogenic differentiation and adipogenic differentiation are thought to be mutually exclusive, and a...

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Veröffentlicht in:	Tissue engineering. Part A 2012-07, Vol.18 (13-14), p.1431-1442
Hauptverfasser:	Doorn, Joyce, Leusink, Maarten, Groen, Nathalie, van de Peppel, Jeroen, van Leeuwen, Johannes P.T.M., van Blitterswijk, Clemens A., de Boer, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Bromo Cyclic Adenosine Monophosphate - pharmacology adipogenesis Adipogenesis - drug effects Alkaline phosphatase Alkaline Phosphatase - metabolism Bone Bucladesine - pharmacology Cell culture Cyclic AMP Cyclic AMP - pharmacology Cyclic AMP-Dependent Protein Kinases - metabolism Dexamethasone Dexamethasone - pharmacology Differentiation Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Humans Kinases Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - enzymology Mesenchyme Mineralization Original Articles Osteogenesis - drug effects Peroxisome proliferator-activated receptors Polymerase chain reaction PPAR gamma - metabolism Protein kinase A Proteins Signal transduction Stem cells stromal cells Tissue engineering
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