Effect of BMP4 on the Growth and Clonogenicity of Human Leukemia and Lymphoma Cells
Bone morphogenetic protein 4 (BMP4) signaling is involved in the maintenance of hematopoietic stem cells. However, the effects of BMP4 on leukemia and lymphoma cells are unknown. The effects of recombinant BMP4 on the in vitro growth of 12 leukemia and lymphoma cell lines were examined. BMP4 treatme...
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| Veröffentlicht in: | Anticancer research 2012-07, Vol.32 (7), p.2813-2817 |
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| container_title | Anticancer research |
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| creator | TAKAHASHI, Yusuke ISHIGAKI, Tomohiro OKUHASHI, Yuki ONO, Aya ITOH, Mai NARA, Nobuo TOHDA, Shuji |
| description | Bone morphogenetic protein 4 (BMP4) signaling is involved in the maintenance of hematopoietic stem cells. However, the effects of BMP4 on leukemia and lymphoma cells are unknown.
The effects of recombinant BMP4 on the in vitro growth of 12 leukemia and lymphoma cell lines were examined.
BMP4 treatment promoted the short-term growth of three cell lines and suppressed the growth of one. Induction of differentiation was not observed. BMP4 treatment suppressed the clonogenicity of four out of the six examined cell lines. BMP4 treatment promoted the growth of Jurkat cells but suppressed their ability to form colonies. BMP4 treatment up-regulated the phosphorylation of SMAD1/5/8 complex, indicating that BMP4 mediated signal transduction in the cells.
BMP4 suppressed the clonogenicity of selected leukemia and lymphoma cell lines. The regulation of BMP4 signaling may be a useful therapeutic approach for leukemia and lymphoma, if appropriate cases are selected. |
| format | Article |
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The effects of recombinant BMP4 on the in vitro growth of 12 leukemia and lymphoma cell lines were examined.
BMP4 treatment promoted the short-term growth of three cell lines and suppressed the growth of one. Induction of differentiation was not observed. BMP4 treatment suppressed the clonogenicity of four out of the six examined cell lines. BMP4 treatment promoted the growth of Jurkat cells but suppressed their ability to form colonies. BMP4 treatment up-regulated the phosphorylation of SMAD1/5/8 complex, indicating that BMP4 mediated signal transduction in the cells.
BMP4 suppressed the clonogenicity of selected leukemia and lymphoma cell lines. The regulation of BMP4 signaling may be a useful therapeutic approach for leukemia and lymphoma, if appropriate cases are selected.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 22753742</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Biological and medical sciences ; Bone morphogenetic protein 4 ; Bone Morphogenetic Protein 4 - pharmacology ; Cell Growth Processes - drug effects ; Cell Line, Tumor ; Colonies ; Differentiation ; Gene Expression - drug effects ; Hematologic and hematopoietic diseases ; Humans ; Leukemia ; Leukemia - drug therapy ; Leukemia - genetics ; Leukemia - metabolism ; Leukemia - pathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma ; Lymphoma - drug therapy ; Lymphoma - genetics ; Lymphoma - metabolism ; Lymphoma - pathology ; Medical sciences ; Neoplastic Stem Cells - drug effects ; Phosphorylation ; Phosphorylation - drug effects ; Recombinant Proteins - pharmacology ; Signal transduction ; Smad Proteins - metabolism ; Stem cells ; Tumor cell lines ; Tumors</subject><ispartof>Anticancer research, 2012-07, Vol.32 (7), p.2813-2817</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26084375$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22753742$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TAKAHASHI, Yusuke</creatorcontrib><creatorcontrib>ISHIGAKI, Tomohiro</creatorcontrib><creatorcontrib>OKUHASHI, Yuki</creatorcontrib><creatorcontrib>ONO, Aya</creatorcontrib><creatorcontrib>ITOH, Mai</creatorcontrib><creatorcontrib>NARA, Nobuo</creatorcontrib><creatorcontrib>TOHDA, Shuji</creatorcontrib><title>Effect of BMP4 on the Growth and Clonogenicity of Human Leukemia and Lymphoma Cells</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Bone morphogenetic protein 4 (BMP4) signaling is involved in the maintenance of hematopoietic stem cells. However, the effects of BMP4 on leukemia and lymphoma cells are unknown.
The effects of recombinant BMP4 on the in vitro growth of 12 leukemia and lymphoma cell lines were examined.
BMP4 treatment promoted the short-term growth of three cell lines and suppressed the growth of one. Induction of differentiation was not observed. BMP4 treatment suppressed the clonogenicity of four out of the six examined cell lines. BMP4 treatment promoted the growth of Jurkat cells but suppressed their ability to form colonies. BMP4 treatment up-regulated the phosphorylation of SMAD1/5/8 complex, indicating that BMP4 mediated signal transduction in the cells.
BMP4 suppressed the clonogenicity of selected leukemia and lymphoma cell lines. The regulation of BMP4 signaling may be a useful therapeutic approach for leukemia and lymphoma, if appropriate cases are selected.</description><subject>Biological and medical sciences</subject><subject>Bone morphogenetic protein 4</subject><subject>Bone Morphogenetic Protein 4 - pharmacology</subject><subject>Cell Growth Processes - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Colonies</subject><subject>Differentiation</subject><subject>Gene Expression - drug effects</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Leukemia - drug therapy</subject><subject>Leukemia - genetics</subject><subject>Leukemia - metabolism</subject><subject>Leukemia - pathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma</subject><subject>Lymphoma - drug therapy</subject><subject>Lymphoma - genetics</subject><subject>Lymphoma - metabolism</subject><subject>Lymphoma - pathology</subject><subject>Medical sciences</subject><subject>Neoplastic Stem Cells - drug effects</subject><subject>Phosphorylation</subject><subject>Phosphorylation - drug effects</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Signal transduction</subject><subject>Smad Proteins - metabolism</subject><subject>Stem cells</subject><subject>Tumor cell lines</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0MFKxDAYBOAgiruuvoLkIngppEnTJEct665QUVDPJU3_uNU2qU2L7NtbteLV01w-hmEO0DIWKo4EZ-QQLQnlJBKE8AU6CeGVkDRVkh2jBaWTEAldose1tWAG7C2-vntIsHd42AHe9P5j2GHtKpw13vkXcLWph_2X246tdjiH8Q3aWn-bfN92O99qnEHThFN0ZHUT4GzOFXq-WT9l2yi_39xmV3nUUZEMUUwE8JRVCpjlBKSJoTSJUlKXqtLEliQFHouYlUKXFRjJBaMKJFScW2Y0W6HLn96u9-8jhKFo62CmBdqBH0MREyZTImgq_0Hp1C0mPdHzmY5lC1XR9XWr-33x-9kELmagg9GN7bUzdfhzKZEJm-wnT-Z0ag</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>TAKAHASHI, Yusuke</creator><creator>ISHIGAKI, Tomohiro</creator><creator>OKUHASHI, Yuki</creator><creator>ONO, Aya</creator><creator>ITOH, Mai</creator><creator>NARA, Nobuo</creator><creator>TOHDA, Shuji</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20120701</creationdate><title>Effect of BMP4 on the Growth and Clonogenicity of Human Leukemia and Lymphoma Cells</title><author>TAKAHASHI, Yusuke ; ISHIGAKI, Tomohiro ; OKUHASHI, Yuki ; ONO, Aya ; ITOH, Mai ; NARA, Nobuo ; TOHDA, Shuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p274t-107e563d9e3f50e8c1ebc4998ab9da0fb06e51713b7abdec857329e8ed55f3ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biological and medical sciences</topic><topic>Bone morphogenetic protein 4</topic><topic>Bone Morphogenetic Protein 4 - pharmacology</topic><topic>Cell Growth Processes - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Colonies</topic><topic>Differentiation</topic><topic>Gene Expression - drug effects</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemia</topic><topic>Leukemia - drug therapy</topic><topic>Leukemia - genetics</topic><topic>Leukemia - metabolism</topic><topic>Leukemia - pathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma</topic><topic>Lymphoma - drug therapy</topic><topic>Lymphoma - genetics</topic><topic>Lymphoma - metabolism</topic><topic>Lymphoma - pathology</topic><topic>Medical sciences</topic><topic>Neoplastic Stem Cells - drug effects</topic><topic>Phosphorylation</topic><topic>Phosphorylation - drug effects</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Signal transduction</topic><topic>Smad Proteins - metabolism</topic><topic>Stem cells</topic><topic>Tumor cell lines</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TAKAHASHI, Yusuke</creatorcontrib><creatorcontrib>ISHIGAKI, Tomohiro</creatorcontrib><creatorcontrib>OKUHASHI, Yuki</creatorcontrib><creatorcontrib>ONO, Aya</creatorcontrib><creatorcontrib>ITOH, Mai</creatorcontrib><creatorcontrib>NARA, Nobuo</creatorcontrib><creatorcontrib>TOHDA, Shuji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TAKAHASHI, Yusuke</au><au>ISHIGAKI, Tomohiro</au><au>OKUHASHI, Yuki</au><au>ONO, Aya</au><au>ITOH, Mai</au><au>NARA, Nobuo</au><au>TOHDA, Shuji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of BMP4 on the Growth and Clonogenicity of Human Leukemia and Lymphoma Cells</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>32</volume><issue>7</issue><spage>2813</spage><epage>2817</epage><pages>2813-2817</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Bone morphogenetic protein 4 (BMP4) signaling is involved in the maintenance of hematopoietic stem cells. However, the effects of BMP4 on leukemia and lymphoma cells are unknown.
The effects of recombinant BMP4 on the in vitro growth of 12 leukemia and lymphoma cell lines were examined.
BMP4 treatment promoted the short-term growth of three cell lines and suppressed the growth of one. Induction of differentiation was not observed. BMP4 treatment suppressed the clonogenicity of four out of the six examined cell lines. BMP4 treatment promoted the growth of Jurkat cells but suppressed their ability to form colonies. BMP4 treatment up-regulated the phosphorylation of SMAD1/5/8 complex, indicating that BMP4 mediated signal transduction in the cells.
BMP4 suppressed the clonogenicity of selected leukemia and lymphoma cell lines. The regulation of BMP4 signaling may be a useful therapeutic approach for leukemia and lymphoma, if appropriate cases are selected.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>22753742</pmid><tpages>5</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences Bone morphogenetic protein 4 Bone Morphogenetic Protein 4 - pharmacology Cell Growth Processes - drug effects Cell Line, Tumor Colonies Differentiation Gene Expression - drug effects Hematologic and hematopoietic diseases Humans Leukemia Leukemia - drug therapy Leukemia - genetics Leukemia - metabolism Leukemia - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma Lymphoma - drug therapy Lymphoma - genetics Lymphoma - metabolism Lymphoma - pathology Medical sciences Neoplastic Stem Cells - drug effects Phosphorylation Phosphorylation - drug effects Recombinant Proteins - pharmacology Signal transduction Smad Proteins - metabolism Stem cells Tumor cell lines Tumors |
| title | Effect of BMP4 on the Growth and Clonogenicity of Human Leukemia and Lymphoma Cells |
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