α-1-Antitrypsin and IFN-γ Reduce the Severity of IC-Mediated Vasculitis by Regulation of Leukocyte Recruitment In Vivo

IC-mediated vasculitis (ICV) can be life threatening. The cellular and immune mechanisms controlling ICV are poorly understood. Therefore, we investigated the role of α-1-antitrypsin (α1AT) and IFN-γ in reducing the severity of ICV in a mouse model in vivo. To induce ICV, mice were challenged with t...

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Veröffentlicht in:	Journal of investigative dermatology 2012-09, Vol.132 (9), p.2286-2295
Hauptverfasser:	Feld, Micha, Goerge, Tobias, Hillgruber, Carina, Steingräber, Annika Kathrin, Fastrich, Michaela, Shpacovitch, Victoria, Steinhoff, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha 1-Antitrypsin - administration & dosage Animal models Animals Arthus reaction Arthus Reaction - drug therapy Biological and medical sciences Capillary Permeability - drug effects Cell activation Chemokine CXCL1 - pharmacology Dermatology Edema Edema - drug therapy gamma -Interferon Interferon-gamma - administration & dosage Leukocyte migration Leukocytes (neutrophilic) Male Medical sciences Mice Mice, Inbred C57BL Microscopy Neutrophils - drug effects Permeability Recombinant Proteins - administration & dosage Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Severity of Illness Index Skin Trypsin Inhibitors - administration & dosage Vasculitis Vasculitis, Leukocytoclastic, Cutaneous - drug therapy
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