Rapid detection of Mycobacterium tuberculosis biomarkers in a sandwich immunoassay format using a waveguide-based optical biosensor

Summary Early diagnosis of active tuberculosis (TB) remains an elusive challenge, especially in individuals with disseminated TB and HIV co-infection. Recent studies have shown a promise for the direct detection of pathogen-specific biomarkers such as lipoarabinomannan (LAM) for the diagnosis of TB...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2012-09, Vol.92 (5), p.407-416
Hauptverfasser:	Mukundan, Harshini, Kumar, Sandeep, Price, Dominique N, Ray, Sonja M, Lee, Ye-Jin, Min, Seonyeong, Eum, Seokyong, Kubicek-Sutherland, Jessica, Resnick, Jesse M, Grace, W. Kevin, Anderson, Aaron S, Hwang, Soo Hee, Cho, Sang Nae, Via, Laura E, Barry, Clifton, Sakamuri, Ramamurthy, Swanson, Basil I
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - metabolism Antigen 85 complex Antigens, Bacterial - metabolism Bacterial Proteins - metabolism biomarkers Biomarkers - metabolism Biosensing Techniques Biosensors Coinfection Diagnosis Early secretory antigenic target 6 Enzyme-Linked Immunosorbent Assay Female HIV Seropositivity - epidemiology HIV Seropositivity - metabolism Human immunodeficiency virus Humans Immunoassay Immunoassays Infectious Disease Lipoarabinomannan Lipoarabinomannans Lipopolysaccharides - metabolism Male Mycobacterium tuberculosis Mycobacterium tuberculosis - isolation & purification Mycobacterium tuberculosis - pathogenicity Pathogens Pulmonary/Respiratory Reagent Kits, Diagnostic Reproducibility of Results Sensitivity and Specificity Tuberculosis Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - epidemiology Tuberculosis, Pulmonary - metabolism Urine Waveguide-based optical biosensor
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