Strong biofilm production but not adhesion virulence factors can discriminate between invasive and commensal Staphylococcus epidermidis strains
Staphylococcus epidermidis is a leading cause of hospital‐acquired infections, mostly associated with the use of medical devices in immunocompromised patients. It originates from the patient's own skin flora, which is subject to severe changes as a result of selective pressure exerted by the ho...
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| Veröffentlicht in: | APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2012-08, Vol.120 (8), p.605-611 |
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| description | Staphylococcus epidermidis is a leading cause of hospital‐acquired infections, mostly associated with the use of medical devices in immunocompromised patients. It originates from the patient's own skin flora, which is subject to severe changes as a result of selective pressure exerted by the hospital environment. This notion led us to compare S. epidermidis isolates from catheter related infections (CRI), non‐catheter related bacteremia (NCRB) and catheter hub cultures (commensal isolates). The collection comprised 47 CRI strains from the Bone Marrow Transplant Centre of Tunis, 25 NCRB strains and 25 commensal isolates from patients hospitalized in the same center. Antimicrobial resistance and virulence‐associated genes (icaABC, aap, atlE, bhp, fbe, embp, and IS256), polysaccharide intercellular adhesin synthesis, and biofilm formation were investigated. The clonal relationship of strains was investigated by pulsed field gel electrophoresis. Whereas bhp, atlE, fbe, embp, and aap were almost ubiquitously amplified, resistance to oxacillin, kanamycin, tobramycin, gentamicin, cotrimoxazole, and fosfomycin, biofilm production, ica genes, and IS256 were significantly more frequent in invasive (CRI and NCRB strains) than in commensal strains. Moreover, strong biofilm production was significantly more frequent among CRI strains than in NCRB strains. In conclusion, when S. epidermidis is isolated from blood cultures, the detection of strong biofilm production may be significant with regard to judging whether the detected strain is an etiologic agent of CRI. |
| doi_str_mv | 10.1111/j.1600-0463.2012.02877.x |
| format | Article |
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It originates from the patient's own skin flora, which is subject to severe changes as a result of selective pressure exerted by the hospital environment. This notion led us to compare S. epidermidis isolates from catheter related infections (CRI), non‐catheter related bacteremia (NCRB) and catheter hub cultures (commensal isolates). The collection comprised 47 CRI strains from the Bone Marrow Transplant Centre of Tunis, 25 NCRB strains and 25 commensal isolates from patients hospitalized in the same center. Antimicrobial resistance and virulence‐associated genes (icaABC, aap, atlE, bhp, fbe, embp, and IS256), polysaccharide intercellular adhesin synthesis, and biofilm formation were investigated. The clonal relationship of strains was investigated by pulsed field gel electrophoresis. Whereas bhp, atlE, fbe, embp, and aap were almost ubiquitously amplified, resistance to oxacillin, kanamycin, tobramycin, gentamicin, cotrimoxazole, and fosfomycin, biofilm production, ica genes, and IS256 were significantly more frequent in invasive (CRI and NCRB strains) than in commensal strains. Moreover, strong biofilm production was significantly more frequent among CRI strains than in NCRB strains. In conclusion, when S. epidermidis is isolated from blood cultures, the detection of strong biofilm production may be significant with regard to judging whether the detected strain is an etiologic agent of CRI.</description><identifier>ISSN: 0903-4641</identifier><identifier>EISSN: 1600-0463</identifier><identifier>DOI: 10.1111/j.1600-0463.2012.02877.x</identifier><identifier>PMID: 22779682</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>Adhesins ; Anti-Bacterial Agents - pharmacology ; Bacteremia ; Bacteremia - genetics ; Bacteremia - metabolism ; Bacteremia - microbiology ; Bacteriology ; biofilm ; Biofilms ; Biological and medical sciences ; Blood culture ; Bone marrow transplantation ; catheter infection ; Catheter-Related Infections - drug therapy ; Catheter-Related Infections - genetics ; Catheter-Related Infections - metabolism ; Catheter-Related Infections - microbiology ; Catheters ; Commensals ; cotrimoxazole ; Cross Infection - genetics ; Cross Infection - metabolism ; Drug resistance ; Drug Resistance, Bacterial ; Electrophoresis, Gel, Pulsed-Field - methods ; fosfomycin ; Fundamental and applied biological sciences. Psychology ; Gel electrophoresis ; Gentamicin ; Hospitalization ; Hospitals ; Humans ; Immunocompromised hosts ; Infection ; Infectious diseases ; Kanamycin ; Medical sciences ; Microbiology ; Miscellaneous ; Nosocomial infections ; Oxacillin ; Polysaccharides ; Polysaccharides, Bacterial - genetics ; Polysaccharides, Bacterial - metabolism ; Skin ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - genetics ; Staphylococcal Infections - metabolism ; Staphylococcal Infections - microbiology ; Staphylococcus epidermidis ; Staphylococcus epidermidis - drug effects ; Staphylococcus epidermidis - genetics ; Staphylococcus epidermidis - isolation & purification ; Staphylococcus epidermidis - physiology ; Tobramycin ; Virulence ; virulence factors ; Virulence Factors - genetics ; Virulence Factors - metabolism</subject><ispartof>APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2012-08, Vol.120 (8), p.605-611</ispartof><rights>2012 The Authors APMIS © 2012 APMIS</rights><rights>2015 INIST-CNRS</rights><rights>2012 The Authors APMIS © 2012 APMIS.</rights><rights>APMIS Copyright 2012 APMIS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0463.2012.02877.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0463.2012.02877.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26150879$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22779682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mekni, Mohamed A.</creatorcontrib><creatorcontrib>Bouchami, Ons</creatorcontrib><creatorcontrib>Achour, Wafa</creatorcontrib><creatorcontrib>Ben Hassen, Assia</creatorcontrib><title>Strong biofilm production but not adhesion virulence factors can discriminate between invasive and commensal Staphylococcus epidermidis strains</title><title>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</title><addtitle>APMIS</addtitle><description>Staphylococcus epidermidis is a leading cause of hospital‐acquired infections, mostly associated with the use of medical devices in immunocompromised patients. It originates from the patient's own skin flora, which is subject to severe changes as a result of selective pressure exerted by the hospital environment. This notion led us to compare S. epidermidis isolates from catheter related infections (CRI), non‐catheter related bacteremia (NCRB) and catheter hub cultures (commensal isolates). The collection comprised 47 CRI strains from the Bone Marrow Transplant Centre of Tunis, 25 NCRB strains and 25 commensal isolates from patients hospitalized in the same center. Antimicrobial resistance and virulence‐associated genes (icaABC, aap, atlE, bhp, fbe, embp, and IS256), polysaccharide intercellular adhesin synthesis, and biofilm formation were investigated. The clonal relationship of strains was investigated by pulsed field gel electrophoresis. Whereas bhp, atlE, fbe, embp, and aap were almost ubiquitously amplified, resistance to oxacillin, kanamycin, tobramycin, gentamicin, cotrimoxazole, and fosfomycin, biofilm production, ica genes, and IS256 were significantly more frequent in invasive (CRI and NCRB strains) than in commensal strains. Moreover, strong biofilm production was significantly more frequent among CRI strains than in NCRB strains. In conclusion, when S. epidermidis is isolated from blood cultures, the detection of strong biofilm production may be significant with regard to judging whether the detected strain is an etiologic agent of CRI.</description><subject>Adhesins</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacteremia</subject><subject>Bacteremia - genetics</subject><subject>Bacteremia - metabolism</subject><subject>Bacteremia - microbiology</subject><subject>Bacteriology</subject><subject>biofilm</subject><subject>Biofilms</subject><subject>Biological and medical sciences</subject><subject>Blood culture</subject><subject>Bone marrow transplantation</subject><subject>catheter infection</subject><subject>Catheter-Related Infections - drug therapy</subject><subject>Catheter-Related Infections - genetics</subject><subject>Catheter-Related Infections - metabolism</subject><subject>Catheter-Related Infections - microbiology</subject><subject>Catheters</subject><subject>Commensals</subject><subject>cotrimoxazole</subject><subject>Cross Infection - genetics</subject><subject>Cross Infection - metabolism</subject><subject>Drug resistance</subject><subject>Drug Resistance, Bacterial</subject><subject>Electrophoresis, Gel, Pulsed-Field - methods</subject><subject>fosfomycin</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gel electrophoresis</subject><subject>Gentamicin</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunocompromised hosts</subject><subject>Infection</subject><subject>Infectious diseases</subject><subject>Kanamycin</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Nosocomial infections</subject><subject>Oxacillin</subject><subject>Polysaccharides</subject><subject>Polysaccharides, Bacterial - genetics</subject><subject>Polysaccharides, Bacterial - metabolism</subject><subject>Skin</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcal Infections - genetics</subject><subject>Staphylococcal Infections - metabolism</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcus epidermidis</subject><subject>Staphylococcus epidermidis - drug effects</subject><subject>Staphylococcus epidermidis - genetics</subject><subject>Staphylococcus epidermidis - isolation & purification</subject><subject>Staphylococcus epidermidis - physiology</subject><subject>Tobramycin</subject><subject>Virulence</subject><subject>virulence factors</subject><subject>Virulence Factors - genetics</subject><subject>Virulence Factors - metabolism</subject><issn>0903-4641</issn><issn>1600-0463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksGO0zAQhiMEYsvCKyBLCIlLgh2ntnPgsFTQRSoLaBdxtBxnwrokdrGdbvsU-8o4tBSJE77Y8nwz43_8ZxkiuCBpvV4XhGGc44rRosSkLHApOC92D7LZKfAwm-Ea07xiFTnLnoSwxokUjD_OzsqS85qJcpbdX0fv7HfUGNeZfkAb79pRR-MsasaIrItItbcQpout8WMPVgPqlI7OB6SVRa0J2pvBWBUBNRDvACwydquC2QJStkXaDQPYoHp0HdXmdt877bQeA4KNacEPJpVAIXplbHiaPepUH-DZcT_Pvr5_d7O4zFeflh8WF6vc0LrieZO0tJXCVDHQqqpwTQkVTddoxpJeUTdYay40ZQzquhNQVZyJdk6EbllLG3qevTrUTYJ_jhCiHJIO6HtlwY1BEkwFwyWtyH-gZZpxOSd1Ql_8g67d6G0SIgmlpUiPoDRRz4_U2AzQyk0an_J7-edXEvDyCKigVd95ZbUJfzlG5ljwqd2bA3dnetif4gTLySVyLSczyMkMcnKJ_O0SuZMXnz9Op5SfH_JNiLA75Sv_QzJO-Vx-u1pK8WXxlqyubuSS_gJk8cDT</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>Mekni, Mohamed A.</creator><creator>Bouchami, Ons</creator><creator>Achour, Wafa</creator><creator>Ben Hassen, Assia</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201208</creationdate><title>Strong biofilm production but not adhesion virulence factors can discriminate between invasive and commensal Staphylococcus epidermidis strains</title><author>Mekni, Mohamed A. ; Bouchami, Ons ; Achour, Wafa ; Ben Hassen, Assia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3947-b001d4a03a6eca44093138bfbc6664189b0cc78c366e99f8e44768d518cd6d3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adhesins</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacteremia</topic><topic>Bacteremia - genetics</topic><topic>Bacteremia - metabolism</topic><topic>Bacteremia - microbiology</topic><topic>Bacteriology</topic><topic>biofilm</topic><topic>Biofilms</topic><topic>Biological and medical sciences</topic><topic>Blood culture</topic><topic>Bone marrow transplantation</topic><topic>catheter infection</topic><topic>Catheter-Related Infections - drug therapy</topic><topic>Catheter-Related Infections - genetics</topic><topic>Catheter-Related Infections - metabolism</topic><topic>Catheter-Related Infections - microbiology</topic><topic>Catheters</topic><topic>Commensals</topic><topic>cotrimoxazole</topic><topic>Cross Infection - genetics</topic><topic>Cross Infection - metabolism</topic><topic>Drug resistance</topic><topic>Drug Resistance, Bacterial</topic><topic>Electrophoresis, Gel, Pulsed-Field - methods</topic><topic>fosfomycin</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gel electrophoresis</topic><topic>Gentamicin</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunocompromised hosts</topic><topic>Infection</topic><topic>Infectious diseases</topic><topic>Kanamycin</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Nosocomial infections</topic><topic>Oxacillin</topic><topic>Polysaccharides</topic><topic>Polysaccharides, Bacterial - genetics</topic><topic>Polysaccharides, Bacterial - metabolism</topic><topic>Skin</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Staphylococcal Infections - genetics</topic><topic>Staphylococcal Infections - metabolism</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcus epidermidis</topic><topic>Staphylococcus epidermidis - drug effects</topic><topic>Staphylococcus epidermidis - genetics</topic><topic>Staphylococcus epidermidis - isolation & purification</topic><topic>Staphylococcus epidermidis - physiology</topic><topic>Tobramycin</topic><topic>Virulence</topic><topic>virulence factors</topic><topic>Virulence Factors - genetics</topic><topic>Virulence Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mekni, Mohamed A.</creatorcontrib><creatorcontrib>Bouchami, Ons</creatorcontrib><creatorcontrib>Achour, Wafa</creatorcontrib><creatorcontrib>Ben Hassen, Assia</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mekni, Mohamed A.</au><au>Bouchami, Ons</au><au>Achour, Wafa</au><au>Ben Hassen, Assia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Strong biofilm production but not adhesion virulence factors can discriminate between invasive and commensal Staphylococcus epidermidis strains</atitle><jtitle>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</jtitle><addtitle>APMIS</addtitle><date>2012-08</date><risdate>2012</risdate><volume>120</volume><issue>8</issue><spage>605</spage><epage>611</epage><pages>605-611</pages><issn>0903-4641</issn><eissn>1600-0463</eissn><abstract>Staphylococcus epidermidis is a leading cause of hospital‐acquired infections, mostly associated with the use of medical devices in immunocompromised patients. It originates from the patient's own skin flora, which is subject to severe changes as a result of selective pressure exerted by the hospital environment. This notion led us to compare S. epidermidis isolates from catheter related infections (CRI), non‐catheter related bacteremia (NCRB) and catheter hub cultures (commensal isolates). The collection comprised 47 CRI strains from the Bone Marrow Transplant Centre of Tunis, 25 NCRB strains and 25 commensal isolates from patients hospitalized in the same center. Antimicrobial resistance and virulence‐associated genes (icaABC, aap, atlE, bhp, fbe, embp, and IS256), polysaccharide intercellular adhesin synthesis, and biofilm formation were investigated. The clonal relationship of strains was investigated by pulsed field gel electrophoresis. Whereas bhp, atlE, fbe, embp, and aap were almost ubiquitously amplified, resistance to oxacillin, kanamycin, tobramycin, gentamicin, cotrimoxazole, and fosfomycin, biofilm production, ica genes, and IS256 were significantly more frequent in invasive (CRI and NCRB strains) than in commensal strains. Moreover, strong biofilm production was significantly more frequent among CRI strains than in NCRB strains. In conclusion, when S. epidermidis is isolated from blood cultures, the detection of strong biofilm production may be significant with regard to judging whether the detected strain is an etiologic agent of CRI.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>22779682</pmid><doi>10.1111/j.1600-0463.2012.02877.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2012-08, Vol.120 (8), p.605-611 |
| issn | 0903-4641 1600-0463 |
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| subjects | Adhesins Anti-Bacterial Agents - pharmacology Bacteremia Bacteremia - genetics Bacteremia - metabolism Bacteremia - microbiology Bacteriology biofilm Biofilms Biological and medical sciences Blood culture Bone marrow transplantation catheter infection Catheter-Related Infections - drug therapy Catheter-Related Infections - genetics Catheter-Related Infections - metabolism Catheter-Related Infections - microbiology Catheters Commensals cotrimoxazole Cross Infection - genetics Cross Infection - metabolism Drug resistance Drug Resistance, Bacterial Electrophoresis, Gel, Pulsed-Field - methods fosfomycin Fundamental and applied biological sciences. Psychology Gel electrophoresis Gentamicin Hospitalization Hospitals Humans Immunocompromised hosts Infection Infectious diseases Kanamycin Medical sciences Microbiology Miscellaneous Nosocomial infections Oxacillin Polysaccharides Polysaccharides, Bacterial - genetics Polysaccharides, Bacterial - metabolism Skin Staphylococcal Infections - drug therapy Staphylococcal Infections - genetics Staphylococcal Infections - metabolism Staphylococcal Infections - microbiology Staphylococcus epidermidis Staphylococcus epidermidis - drug effects Staphylococcus epidermidis - genetics Staphylococcus epidermidis - isolation & purification Staphylococcus epidermidis - physiology Tobramycin Virulence virulence factors Virulence Factors - genetics Virulence Factors - metabolism |
| title | Strong biofilm production but not adhesion virulence factors can discriminate between invasive and commensal Staphylococcus epidermidis strains |
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