Differential susceptibility of Cx26 mutations associated with epidermal dysplasias to peptidoglycan derived from Staphylococcus aureus and Staphylococcus epidermidis

Mutations in Connexin26 (Cx26) give rise to a spectrum of dominantly inherited hyperproliferating skin disorders, the severest being keratitis–ichthyosis–deafness (KID) syndrome, an inflammatory skin disorder, with patients prone to opportunistic infections. We compared the effects of peptidoglycan...

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Veröffentlicht in:	Experimental dermatology 2012-08, Vol.21 (8), p.592-598
Hauptverfasser:	Donnelly, Steven, English, Grant, de Zwart-Storm, Eugene A., Lang, Sue, van Steensel, Maurice A. M., Martin, Patricia E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism ATP Bacterial diseases Biological and medical sciences Carbenoxolone - pharmacology Cell Line Channel gating Commensals Complex syndromes Connexin 26 connexin26 Connexins Connexins - genetics Connexins - metabolism Deafness - genetics Dermatology disorder Dyskeratosis Dysplasia Epidermis - abnormalities Genotype HeLa Cells hemichannel activity Human bacterial diseases Humans Ichthyosis - genetics Infectious diseases Inflammation Inflammatory diseases innate immunity Interleukin 6 Interleukin-6 - metabolism Keratinocytes Keratinocytes - drug effects Keratinocytes - metabolism Keratinocytes - pathology Keratitis - genetics KID syndrome Medical genetics Medical sciences Mutation Mutation - genetics Opportunist infection Pathogens Peptidoglycan - metabolism Peptidoglycan - pharmacology peptidoglycans Phenotype Skin Skin Diseases, Genetic - genetics Staphylococcal infections, streptococcal infections, pneumococcal infections Staphylococcus aureus Staphylococcus aureus - metabolism Staphylococcus epidermidis Staphylococcus epidermidis - metabolism Transfection
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