Monoclonal TCR-redirected tumor cell killing

T cell receptor (TCR)-based immunotherapeutic approaches have so far had limited success because of a lack of specific immune recognition and activation by the TCR. Here Nathaniel Liddy and his colleagues describe the generation, optimization and characterization of a new set of reagents—immune-mobi...

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Veröffentlicht in:	Nature medicine 2012-06, Vol.18 (6), p.980-987
Hauptverfasser:	Liddy, Nathaniel, Bossi, Giovanna, Adams, Katherine J, Lissina, Anna, Mahon, Tara M, Hassan, Namir J, Gavarret, Jessie, Bianchi, Frayne C, Pumphrey, Nicholas J, Ladell, Kristin, Gostick, Emma, Sewell, Andrew K, Lissin, Nikolai M, Harwood, Naomi E, Molloy, Peter E, Li, Yi, Cameron, Brian J, Sami, Malkit, Baston, Emma E, Todorov, Penio T, Paston, Samantha J, Dennis, Rebecca E, Harper, Jane V, Dunn, Steve M, Ashfield, Rebecca, Johnson, Andy, McGrath, Yvonne, Plesa, Gabriela, June, Carl H, Kalos, Michael, Price, David A, Vuidepot, Annelise, Williams, Daniel D, Sutton, Deborah H, Jakobsen, Bent K
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/251 692/699/67/580 Analysis Animals Antigen receptors, T cell Biomedical and Life Sciences Biomedicine Cancer Cancer cells Cancer Research CD8-Positive T-Lymphocytes - immunology Cytotoxicity, Immunologic Humans Immunity (Disease) Immunologic Memory Immunotherapy Infectious Diseases Interferon-gamma - biosynthesis Lymphocyte Activation Metabolic Diseases Mice Mice, SCID Molecular Medicine Monoclonal antibodies Neoplasms, Experimental - immunology Neoplasms, Experimental - therapy Neurosciences Reagents Receptors Receptors, Antigen, T-Cell - physiology T cell receptors T cells technical-report Tumors
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