MicroRNA expression profiling of NGF-treated PC12 cells revealed a critical role for miR-221 in neuronal differentiation

► We identified NGF-regulated miRNAs in PC12 cells by microarray analysis. ► miR-221 overexpression induced and enhanced neuronal differentiation. ► Knockdown of miR-221 attenuated NGF-induced neuronal differentiation. ► miR-221 overexpression decreased protein expression of Foxo3a and Apaf-1. ► miR...

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Veröffentlicht in:	Neurochemistry international 2012-06, Vol.60 (8), p.743-750
Hauptverfasser:	Hamada, Nanako, Fujita, Yasunori, Kojima, Toshio, Kitamoto, Aya, Akao, Yukihiro, Nozawa, Yoshinori, Ito, Masafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apaf-1 protein Apoptosis Axonogenesis Biological and medical sciences Blotting, Western Cell Differentiation - genetics Differentiation FOXO3 protein Fundamental and applied biological sciences. Psychology Gene Expression Profiling MicroRNA microarray MicroRNAs - genetics MicroRNAs - physiology miR-221 miRNA mRNA Nerve growth factor Nerve Growth Factor - pharmacology Neuronal differentiation Neurons - cytology Neurons - drug effects non-coding RNA PC12 Cells Pheochromocytoma cells Polymerase chain reaction Rats Reverse Transcriptase Polymerase Chain Reaction Synapsin I Synaptogenesis Translation Vertebrates: nervous system and sense organs
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