An fMRI study of reduced perceptual load-dependent modulation of task-irrelevant activity in adults with autism spectrum conditions
Recent studies on selective attention have demonstrated that the perceptual load of a task determines the processing stage at which irrelevant sensory stimuli are filtered out. Although individuals with autism spectrum conditions (ASC) have been repeatedly reported to display several kinds of abnorm...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2012-07, Vol.61 (4), p.1176-1187 |
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| creator | Ohta, Haruhisa Yamada, Takashi Watanabe, Hiromi Kanai, Chieko Tanaka, Eizaburo Ohno, Taisei Takayama, Yuko Iwanami, Akira Kato, Nobumasa Hashimoto, Ryu-ichiro |
| description | Recent studies on selective attention have demonstrated that the perceptual load of a task determines the processing stage at which irrelevant sensory stimuli are filtered out. Although individuals with autism spectrum conditions (ASC) have been repeatedly reported to display several kinds of abnormal behavior related to attention deficits, the neural mechanisms underlying these deficits have not been well investigated within the framework of the load dependency of selective attention. The present study used functional magnetic resonance imaging (fMRI) to examine the brain responses of adults with high-functioning ASC to irrelevant visual distractors while performing a visual target detection task under high or low perceptual load. We observed that the increased perceptual load activated regions of the fronto-parietal attention network of controls and ASC comparably. On the other hand, the visual cortex activity evoked by visual distractors was less modulated by the increased perceptual load in ASC than in controls. Simple regression analyses showed that the degree of the modulation was significantly correlated with the severity of the autistic symptoms. We also observed reduced load-dependent modulation of the functional connectivity between the intraparietal and visual regions in the ASC group. These results revealed neural correlates for abnormal perceptual load-dependent engagement of visual attention in ASC, which may underlie aspects of cognitive and behavioral characteristics of these disorders. |
| doi_str_mv | 10.1016/j.neuroimage.2012.03.042 |
| format | Article |
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Although individuals with autism spectrum conditions (ASC) have been repeatedly reported to display several kinds of abnormal behavior related to attention deficits, the neural mechanisms underlying these deficits have not been well investigated within the framework of the load dependency of selective attention. The present study used functional magnetic resonance imaging (fMRI) to examine the brain responses of adults with high-functioning ASC to irrelevant visual distractors while performing a visual target detection task under high or low perceptual load. We observed that the increased perceptual load activated regions of the fronto-parietal attention network of controls and ASC comparably. On the other hand, the visual cortex activity evoked by visual distractors was less modulated by the increased perceptual load in ASC than in controls. Simple regression analyses showed that the degree of the modulation was significantly correlated with the severity of the autistic symptoms. We also observed reduced load-dependent modulation of the functional connectivity between the intraparietal and visual regions in the ASC group. These results revealed neural correlates for abnormal perceptual load-dependent engagement of visual attention in ASC, which may underlie aspects of cognitive and behavioral characteristics of these disorders.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2012.03.042</identifier><identifier>PMID: 22465842</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Attention - physiology ; Attention deficit hyperactivity disorder ; Autism ; Brain ; Brain - physiopathology ; Brain Mapping ; Child ; Child Development Disorders, Pervasive - physiopathology ; Female ; Humans ; Image Interpretation, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Neural Pathways - physiopathology ; Visual task performance</subject><ispartof>NeuroImage (Orlando, Fla.), 2012-07, Vol.61 (4), p.1176-1187</ispartof><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Jul 16, 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-2530ba4cdd4252af7737251e4474129041b4f826e31f49ef4c161980a03acab63</citedby><cites>FETCH-LOGICAL-c435t-2530ba4cdd4252af7737251e4474129041b4f826e31f49ef4c161980a03acab63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1506873176?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978,64366,64368,64370,72220</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22465842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohta, Haruhisa</creatorcontrib><creatorcontrib>Yamada, Takashi</creatorcontrib><creatorcontrib>Watanabe, Hiromi</creatorcontrib><creatorcontrib>Kanai, Chieko</creatorcontrib><creatorcontrib>Tanaka, Eizaburo</creatorcontrib><creatorcontrib>Ohno, Taisei</creatorcontrib><creatorcontrib>Takayama, Yuko</creatorcontrib><creatorcontrib>Iwanami, Akira</creatorcontrib><creatorcontrib>Kato, Nobumasa</creatorcontrib><creatorcontrib>Hashimoto, Ryu-ichiro</creatorcontrib><title>An fMRI study of reduced perceptual load-dependent modulation of task-irrelevant activity in adults with autism spectrum conditions</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>Recent studies on selective attention have demonstrated that the perceptual load of a task determines the processing stage at which irrelevant sensory stimuli are filtered out. Although individuals with autism spectrum conditions (ASC) have been repeatedly reported to display several kinds of abnormal behavior related to attention deficits, the neural mechanisms underlying these deficits have not been well investigated within the framework of the load dependency of selective attention. The present study used functional magnetic resonance imaging (fMRI) to examine the brain responses of adults with high-functioning ASC to irrelevant visual distractors while performing a visual target detection task under high or low perceptual load. We observed that the increased perceptual load activated regions of the fronto-parietal attention network of controls and ASC comparably. On the other hand, the visual cortex activity evoked by visual distractors was less modulated by the increased perceptual load in ASC than in controls. Simple regression analyses showed that the degree of the modulation was significantly correlated with the severity of the autistic symptoms. 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These results revealed neural correlates for abnormal perceptual load-dependent engagement of visual attention in ASC, which may underlie aspects of cognitive and behavioral characteristics of these disorders.</description><subject>Adult</subject><subject>Attention - physiology</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Autism</subject><subject>Brain</subject><subject>Brain - physiopathology</subject><subject>Brain Mapping</subject><subject>Child</subject><subject>Child Development Disorders, Pervasive - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Neural Pathways - physiopathology</subject><subject>Visual task performance</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkUuLFDEURoMozjj6FyTgxk3V5FmP5Tj4GBgRRNchndzStFVJmUdLr_3jpuhxBDe6SiDnfpd8ByFMSUsJ7S73rYcSg1v0F2gZoawlvCWCPUDnlIyyGWXPHm53yZuB0vEMPUlpTwgZqRgeozPGRCcHwc7RzyuPp_cfb3DKxR5xmHAEWwxYvEI0sOaiZzwHbRsLK3gLPuMl2DLr7ILf-KzTt8bFCDMcdH3VJruDy0fsPNYVzAn_cPkr1iW7tOC0gsmxLNgEb90Wkp6iR5OeEzy7Oy_Q5zevP12_a24_vL25vrptjOAyN0xystPCWCuYZHrqe94zSUGIXlA2EkF3YhpYB5xOYoRJGNrRcSCacG30ruMX6OUpd43he4GU1eKSgXnWHkJJihI-dLUkLv4DZWTgYhy31Bd_oftQoq8fUVSSbug57TdqOFEmhpQiTGqNVV881ii1OVV79cep2pwqwlV1Wkef3y0ouwXs_eBviRV4dQKglndwEFUyDnyV6GItW9ng_r3lF0ZbuJI</recordid><startdate>20120716</startdate><enddate>20120716</enddate><creator>Ohta, Haruhisa</creator><creator>Yamada, Takashi</creator><creator>Watanabe, Hiromi</creator><creator>Kanai, Chieko</creator><creator>Tanaka, Eizaburo</creator><creator>Ohno, Taisei</creator><creator>Takayama, Yuko</creator><creator>Iwanami, Akira</creator><creator>Kato, Nobumasa</creator><creator>Hashimoto, Ryu-ichiro</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20120716</creationdate><title>An fMRI study of reduced perceptual load-dependent modulation of task-irrelevant activity in adults with autism spectrum conditions</title><author>Ohta, Haruhisa ; Yamada, Takashi ; Watanabe, Hiromi ; Kanai, Chieko ; Tanaka, Eizaburo ; Ohno, Taisei ; Takayama, Yuko ; Iwanami, Akira ; Kato, Nobumasa ; Hashimoto, Ryu-ichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-2530ba4cdd4252af7737251e4474129041b4f826e31f49ef4c161980a03acab63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Attention - 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Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>NeuroImage (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohta, Haruhisa</au><au>Yamada, Takashi</au><au>Watanabe, Hiromi</au><au>Kanai, Chieko</au><au>Tanaka, Eizaburo</au><au>Ohno, Taisei</au><au>Takayama, Yuko</au><au>Iwanami, Akira</au><au>Kato, Nobumasa</au><au>Hashimoto, Ryu-ichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An fMRI study of reduced perceptual load-dependent modulation of task-irrelevant activity in adults with autism spectrum conditions</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2012-07-16</date><risdate>2012</risdate><volume>61</volume><issue>4</issue><spage>1176</spage><epage>1187</epage><pages>1176-1187</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><abstract>Recent studies on selective attention have demonstrated that the perceptual load of a task determines the processing stage at which irrelevant sensory stimuli are filtered out. Although individuals with autism spectrum conditions (ASC) have been repeatedly reported to display several kinds of abnormal behavior related to attention deficits, the neural mechanisms underlying these deficits have not been well investigated within the framework of the load dependency of selective attention. The present study used functional magnetic resonance imaging (fMRI) to examine the brain responses of adults with high-functioning ASC to irrelevant visual distractors while performing a visual target detection task under high or low perceptual load. We observed that the increased perceptual load activated regions of the fronto-parietal attention network of controls and ASC comparably. On the other hand, the visual cortex activity evoked by visual distractors was less modulated by the increased perceptual load in ASC than in controls. Simple regression analyses showed that the degree of the modulation was significantly correlated with the severity of the autistic symptoms. We also observed reduced load-dependent modulation of the functional connectivity between the intraparietal and visual regions in the ASC group. These results revealed neural correlates for abnormal perceptual load-dependent engagement of visual attention in ASC, which may underlie aspects of cognitive and behavioral characteristics of these disorders.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>22465842</pmid><doi>10.1016/j.neuroimage.2012.03.042</doi><tpages>12</tpages></addata></record> |
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| subjects | Adult Attention - physiology Attention deficit hyperactivity disorder Autism Brain Brain - physiopathology Brain Mapping Child Child Development Disorders, Pervasive - physiopathology Female Humans Image Interpretation, Computer-Assisted Magnetic Resonance Imaging Male Neural Pathways - physiopathology Visual task performance |
| title | An fMRI study of reduced perceptual load-dependent modulation of task-irrelevant activity in adults with autism spectrum conditions |
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