Performance characteristics of Pap test, VIA, VILI, HR-HPV testing, cervicography, and colposcopy in diagnosis of significant cervical pathology
We sought to evaluate the performance of diagnostic tools to establish an affordable setting for early detection of cervical cancer in developing countries. We compared the performance of different screening tests and their feasibility in a cohort of over 12,000 women: conventional Pap smear, liquid...
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| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2012-06, Vol.460 (6), p.577-585 |
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| creator | Longatto, Adhemar Naud, Paulo Derchain, Sophie F. M. Roteli-Martins, Cecília Tatti, Sílvio Hammes, Luciano Serpa Sarian, Luis Otavio Eržen, Mojca Branca, Margherita de Matos, Jean Carlos Gontijo, Renata Maeda, Marina Y. S. Lima, Temístocles Costa, Silvano Syrjänen, Stina Syrjänen, Kari |
| description | We sought to evaluate the performance of diagnostic tools to establish an affordable setting for early detection of cervical cancer in developing countries. We compared the performance of different screening tests and their feasibility in a cohort of over 12,000 women: conventional Pap smear, liquid-based cytology, visual inspection with acetic acid (VIA), visual inspection with Iodine solution (VILI), cervicography, screening colposcopy, and high-risk human papillomavirus (HPV) testing (HR-HPV) collected by physician and by self-sampling. HR-HPV assay collected by the physician has the highest sensitivity (80 %), but high unnecessary referrals to colposcopy (15.1 %). HR-HPV test in self-sampling had a markedly lower (57.1 %) sensitivity. VIA, VILI, and cervicography had a poor sensitivity (47.4, 55, and 28.6 %, respectively). Colposcopy presented with sensitivity of 100 % in detecting CIN2+, but the lowest specificity (66.9 %). Co-testing with VIA and VILI Pap test increased the sensitivity of stand-alone Pap test from 71.6 to 87.1 % and 71.6 to 95 %, respectively, but with high number of unnecessary colposcopies. Co-testing with HR-HPV importantly increased the sensitivity of Pap test (to 86 %), but with high number of unnecessary colposcopies (17.5 %). Molecular tests adjunct to Pap test seems a realistic option to improve the detection of high-grade lesions in population-based screening programs.
European Commission, INCO-DEV Programme (contract# ICA4-CT-2001-10013). The generous contribution of DIGENE Corporation (USA) donating the HCII tests at our disposal is gratefully acknowledged. |
| doi_str_mv | 10.1007/s00428-012-1242-y |
| format | Article |
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European Commission, INCO-DEV Programme (contract# ICA4-CT-2001-10013). The generous contribution of DIGENE Corporation (USA) donating the HCII tests at our disposal is gratefully acknowledged.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-012-1242-y</identifier><identifier>PMID: 22562132</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer</publisher><subject>Acetic Acid ; Biological and medical sciences ; Biopsy ; Cancer prevention ; Cervical cancer ; Cervical Intraepithelial Neoplasia - diagnosis ; Cervical Intraepithelial Neoplasia - pathology ; Cervix ; Cervix Uteri - pathology ; Ciências Médicas ; Cohort Studies ; Colposcopy ; Colposcopy - utilization ; Cytology ; Developing Countries ; Female ; Human papillomavirus ; Humans ; Hybrid capture ; Inspection ; Investigative techniques, diagnostic techniques (general aspects) ; Iodides ; Iodine ; LDCs ; Mass Screening ; Medical sciences ; Medicina Básica ; Medicine ; Medicine & Public Health ; Original Article ; Pap test ; Papanicolaou Test ; Papillomaviridae - genetics ; Papillomavirus Infections - diagnosis ; Papillomavirus Infections - pathology ; Pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Risk groups ; Science & Technology ; Screening program ; Sensitivity and Specificity ; Tumor Virus Infections - diagnosis ; Tumor Virus Infections - pathology ; Uterine Cervical Neoplasms - diagnosis ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - prevention & control ; Vaginal Smears</subject><ispartof>Virchows Archiv : an international journal of pathology, 2012-06, Vol.460 (6), p.577-585</ispartof><rights>Springer-Verlag 2012</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-1f865fd144c953d702d86b439d54005682b128ed0584ca3295932df143e8f2203</citedby><cites>FETCH-LOGICAL-c460t-1f865fd144c953d702d86b439d54005682b128ed0584ca3295932df143e8f2203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00428-012-1242-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00428-012-1242-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26036728$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22562132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Longatto, Adhemar</creatorcontrib><creatorcontrib>Naud, Paulo</creatorcontrib><creatorcontrib>Derchain, Sophie F. M.</creatorcontrib><creatorcontrib>Roteli-Martins, Cecília</creatorcontrib><creatorcontrib>Tatti, Sílvio</creatorcontrib><creatorcontrib>Hammes, Luciano Serpa</creatorcontrib><creatorcontrib>Sarian, Luis Otavio</creatorcontrib><creatorcontrib>Eržen, Mojca</creatorcontrib><creatorcontrib>Branca, Margherita</creatorcontrib><creatorcontrib>de Matos, Jean Carlos</creatorcontrib><creatorcontrib>Gontijo, Renata</creatorcontrib><creatorcontrib>Maeda, Marina Y. S.</creatorcontrib><creatorcontrib>Lima, Temístocles</creatorcontrib><creatorcontrib>Costa, Silvano</creatorcontrib><creatorcontrib>Syrjänen, Stina</creatorcontrib><creatorcontrib>Syrjänen, Kari</creatorcontrib><title>Performance characteristics of Pap test, VIA, VILI, HR-HPV testing, cervicography, and colposcopy in diagnosis of significant cervical pathology</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><addtitle>Virchows Arch</addtitle><description>We sought to evaluate the performance of diagnostic tools to establish an affordable setting for early detection of cervical cancer in developing countries. We compared the performance of different screening tests and their feasibility in a cohort of over 12,000 women: conventional Pap smear, liquid-based cytology, visual inspection with acetic acid (VIA), visual inspection with Iodine solution (VILI), cervicography, screening colposcopy, and high-risk human papillomavirus (HPV) testing (HR-HPV) collected by physician and by self-sampling. HR-HPV assay collected by the physician has the highest sensitivity (80 %), but high unnecessary referrals to colposcopy (15.1 %). HR-HPV test in self-sampling had a markedly lower (57.1 %) sensitivity. VIA, VILI, and cervicography had a poor sensitivity (47.4, 55, and 28.6 %, respectively). Colposcopy presented with sensitivity of 100 % in detecting CIN2+, but the lowest specificity (66.9 %). Co-testing with VIA and VILI Pap test increased the sensitivity of stand-alone Pap test from 71.6 to 87.1 % and 71.6 to 95 %, respectively, but with high number of unnecessary colposcopies. Co-testing with HR-HPV importantly increased the sensitivity of Pap test (to 86 %), but with high number of unnecessary colposcopies (17.5 %). Molecular tests adjunct to Pap test seems a realistic option to improve the detection of high-grade lesions in population-based screening programs.
European Commission, INCO-DEV Programme (contract# ICA4-CT-2001-10013). The generous contribution of DIGENE Corporation (USA) donating the HCII tests at our disposal is gratefully acknowledged.</description><subject>Acetic Acid</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Cancer prevention</subject><subject>Cervical cancer</subject><subject>Cervical Intraepithelial Neoplasia - diagnosis</subject><subject>Cervical Intraepithelial Neoplasia - pathology</subject><subject>Cervix</subject><subject>Cervix Uteri - pathology</subject><subject>Ciências Médicas</subject><subject>Cohort Studies</subject><subject>Colposcopy</subject><subject>Colposcopy - utilization</subject><subject>Cytology</subject><subject>Developing Countries</subject><subject>Female</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Hybrid capture</subject><subject>Inspection</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Iodides</subject><subject>Iodine</subject><subject>LDCs</subject><subject>Mass Screening</subject><subject>Medical sciences</subject><subject>Medicina Básica</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Pap test</subject><subject>Papanicolaou Test</subject><subject>Papillomaviridae - genetics</subject><subject>Papillomavirus Infections - diagnosis</subject><subject>Papillomavirus Infections - pathology</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Risk groups</subject><subject>Science & Technology</subject><subject>Screening program</subject><subject>Sensitivity and Specificity</subject><subject>Tumor Virus Infections - diagnosis</subject><subject>Tumor Virus Infections - pathology</subject><subject>Uterine Cervical Neoplasms - diagnosis</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - prevention & control</subject><subject>Vaginal Smears</subject><issn>0945-6317</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kd-K1DAUh4Mo7rj6AN5IQIS9mGpykqbp5bK4zsCAg-jehkyadrJ0kpp0FvoWPrKZ7fgHwZsEku93cnI-hF5T8p4SUn1IhHCQBaFQUOBQTE_QgnIGBTBSPUULUvOyEIxWF-hFSveEAJVUPEcXAKUAymCBfmxtbEM8aG8sNnsdtRltdGl0JuHQ4q0e8GjTuMR36-vTslkv8epLsdrePZ473y2xsfHBmdBFPeynJda-wSb0Q0gmDBN2HjdOdz4k91gyuc671hntx3NS93jQ4z70oZteomet7pN9dd4v0bfbj19vVsXm86f1zfWmMFyQsaCtFGXbUM5NXbKmItBIseOsbkpOSCkk7ChI25BScqMZ1GXNoGnzdKxsAQi7RFdz3SGG78f8E3Vwydi-196GY1KUMClIHpnI6Nt_0PtwjD53lylac8EqzjNFZ8rEkFK0rRqiO-g4ZUiddKlZl8q61EmXmnLmzbnycXewze_ELz8ZeHcGdMpjamP25NIfThAmKpCZg5lL-cp3Nv7d4v9fx3MoGq0HFe1D9q5zQgIoUfHcwU-by7ZK</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Longatto, Adhemar</creator><creator>Naud, Paulo</creator><creator>Derchain, Sophie F. 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M. ; Roteli-Martins, Cecília ; Tatti, Sílvio ; Hammes, Luciano Serpa ; Sarian, Luis Otavio ; Eržen, Mojca ; Branca, Margherita ; de Matos, Jean Carlos ; Gontijo, Renata ; Maeda, Marina Y. 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M.</au><au>Roteli-Martins, Cecília</au><au>Tatti, Sílvio</au><au>Hammes, Luciano Serpa</au><au>Sarian, Luis Otavio</au><au>Eržen, Mojca</au><au>Branca, Margherita</au><au>de Matos, Jean Carlos</au><au>Gontijo, Renata</au><au>Maeda, Marina Y. S.</au><au>Lima, Temístocles</au><au>Costa, Silvano</au><au>Syrjänen, Stina</au><au>Syrjänen, Kari</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Performance characteristics of Pap test, VIA, VILI, HR-HPV testing, cervicography, and colposcopy in diagnosis of significant cervical pathology</atitle><jtitle>Virchows Archiv : an international journal of pathology</jtitle><stitle>Virchows Arch</stitle><addtitle>Virchows Arch</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>460</volume><issue>6</issue><spage>577</spage><epage>585</epage><pages>577-585</pages><issn>0945-6317</issn><eissn>1432-2307</eissn><abstract>We sought to evaluate the performance of diagnostic tools to establish an affordable setting for early detection of cervical cancer in developing countries. We compared the performance of different screening tests and their feasibility in a cohort of over 12,000 women: conventional Pap smear, liquid-based cytology, visual inspection with acetic acid (VIA), visual inspection with Iodine solution (VILI), cervicography, screening colposcopy, and high-risk human papillomavirus (HPV) testing (HR-HPV) collected by physician and by self-sampling. HR-HPV assay collected by the physician has the highest sensitivity (80 %), but high unnecessary referrals to colposcopy (15.1 %). HR-HPV test in self-sampling had a markedly lower (57.1 %) sensitivity. VIA, VILI, and cervicography had a poor sensitivity (47.4, 55, and 28.6 %, respectively). Colposcopy presented with sensitivity of 100 % in detecting CIN2+, but the lowest specificity (66.9 %). Co-testing with VIA and VILI Pap test increased the sensitivity of stand-alone Pap test from 71.6 to 87.1 % and 71.6 to 95 %, respectively, but with high number of unnecessary colposcopies. Co-testing with HR-HPV importantly increased the sensitivity of Pap test (to 86 %), but with high number of unnecessary colposcopies (17.5 %). Molecular tests adjunct to Pap test seems a realistic option to improve the detection of high-grade lesions in population-based screening programs.
European Commission, INCO-DEV Programme (contract# ICA4-CT-2001-10013). The generous contribution of DIGENE Corporation (USA) donating the HCII tests at our disposal is gratefully acknowledged.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer</pub><pmid>22562132</pmid><doi>10.1007/s00428-012-1242-y</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Virchows Archiv : an international journal of pathology, 2012-06, Vol.460 (6), p.577-585 |
| issn | 0945-6317 1432-2307 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1038600026 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acetic Acid Biological and medical sciences Biopsy Cancer prevention Cervical cancer Cervical Intraepithelial Neoplasia - diagnosis Cervical Intraepithelial Neoplasia - pathology Cervix Cervix Uteri - pathology Ciências Médicas Cohort Studies Colposcopy Colposcopy - utilization Cytology Developing Countries Female Human papillomavirus Humans Hybrid capture Inspection Investigative techniques, diagnostic techniques (general aspects) Iodides Iodine LDCs Mass Screening Medical sciences Medicina Básica Medicine Medicine & Public Health Original Article Pap test Papanicolaou Test Papillomaviridae - genetics Papillomavirus Infections - diagnosis Papillomavirus Infections - pathology Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Risk groups Science & Technology Screening program Sensitivity and Specificity Tumor Virus Infections - diagnosis Tumor Virus Infections - pathology Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - prevention & control Vaginal Smears |
| title | Performance characteristics of Pap test, VIA, VILI, HR-HPV testing, cervicography, and colposcopy in diagnosis of significant cervical pathology |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T09%3A18%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Performance%20characteristics%20of%20Pap%20test,%20VIA,%20VILI,%20HR-HPV%20testing,%20cervicography,%20and%20colposcopy%20in%20diagnosis%20of%20significant%20cervical%20pathology&rft.jtitle=Virchows%20Archiv%20:%20an%20international%20journal%20of%20pathology&rft.au=Longatto,%20Adhemar&rft.date=2012-06-01&rft.volume=460&rft.issue=6&rft.spage=577&rft.epage=585&rft.pages=577-585&rft.issn=0945-6317&rft.eissn=1432-2307&rft_id=info:doi/10.1007/s00428-012-1242-y&rft_dat=%3Cproquest_cross%3E2682489031%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1019463744&rft_id=info:pmid/22562132&rfr_iscdi=true |