Anti-androgen receptor activity of apoptotic CK2 inhibitor CX4945 in human prostate cancer LNCap cells

CX4945, a potent and selective small molecule inhibitor of CK2, exhibits its anti-cancer activity in LNCap cells via the independent inhibitions of AR and Akt-survivin signalings. Androgen receptor (AR) is crucial for transcriptional signaling in prostate cancers. The anti-cancer activity of protein...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-09, Vol.22 (17), p.5470-5474
Hauptverfasser:	Ryu, Byung Jun, Baek, Seung-hwa, Kim, Jiyeon, Bae, Su Jung, Chang, Sung-Youn, Heo, Jung-Nyoung, Lee, Hyuk, Lee, Sang Yeol, Kim, Seong Hwan
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Androgen Antagonists - pharmacology Androgen receptor Androgen receptors Androgens anticarcinogenic activity Antineoplastic Agents - pharmacology Antitumor agents Apoptosis Apoptosis - drug effects Biological and medical sciences Casein Casein kinase II Casein Kinase II - antagonists & inhibitors Cell Line, Tumor CK2 Clinical trials CX4945 Humans IAP protein Male Medical sciences Naphthyridines - pharmacology Pharmacology. Drug treatments Phosphorylation Prostate cancer prostatic neoplasms Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism protein kinases Receptors, Androgen - metabolism Transcription transcription (genetics) Transcription activation transcriptional activation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!