Different in vitro toxicity of ribosome-inactivating proteins (RIPs) on sensory neurons and Schwann cells

► We modified the protocols of primary neuron and glial cell cultures. ► The three RIPs, TCS, RTA and RCA, have different in vitro toxicity on different cells. ► Schwann cells may act as a protective barrier for neurons against RIPs, such as RTA. ► The three RIPs have DNase activity and all induce a...

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Veröffentlicht in:	Neuroscience letters 2012-08, Vol.524 (2), p.89-94
Hauptverfasser:	Tong, Wai-Man, Sha, Ou, Ng, Tzi-Bun, Cho, Eric Y.P., Kwong, Wing-Hang
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglutinins Animals Annexin V Apoptosis Apoptosis - drug effects Cell culture Cells, Cultured Cytoplasm Female Ganglia, Spinal - cytology Nervous system Neuritis Neurotoxicity Plant Lectins - toxicity Primary Cell Culture Primary culture Rats Rats, Sprague-Dawley ribosome-inactivating protein Ribosome-inactivating proteins Ricin Ricin - toxicity Ricin A chain Ricinus communis Ricinus communis agglutinin Schwann cells Schwann Cells - cytology Schwann Cells - drug effects Sensory neurons Sensory Receptor Cells - cytology Sensory Receptor Cells - drug effects Trichosanthin Trichosanthin - toxicity
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